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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2008 Volume 19 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

The possible roles for polyamines in the initiation process of SV40 DNA replication in vitro

  • Authors:
    • Dong-Gil Kim
    • Juan Du
    • Chunhui Miao
    • Jee H. Jung
    • Sang Chul Park
    • Dong-Kyoo Kim

  • View Affiliations / Copyright

    Affiliations: Department of Biomedicinal Chemistry, and Institute of Functional Materials, Inje University, Kimhae 621-749, Korea
  • Pages: 535-539
    |
    Published online on: February 1, 2008
       https://doi.org/10.3892/or.19.2.535
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Abstract

The polyamines are aliphatic cations which are present in millimolar concentrations in all mammalian cells, and are required for optimal growth of almost all cell types. In this study, the roles of polyamines in DNA replication in vitro and the mechanism by which polyamines affected DNA replication were examined using simian virus 40 DNA replication system in vitro. We found that polyamines inhibited DNA replication, but it is not clear at which stage this occurs. Spermidine inhibited the DNA cleavage by topoisomerase I at 8.0 mM, but stimulated its activity at 1.0 mM. Spermine also inhibited its activity at 4.0 mM, but stimulated at 1.0 mM. The ssDNA binding activity of replication protein A was slightly affected by polyamines. Polyamines, especially spermine, also significantly reduced polymerase α-primase activity at 133 µM. Taken together, we suggest that the major inhibition of SV40 DNA replication may be due to the inhibition of pol α-primase activity, and possible roles for polyamines in the initiation process are discussed.

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Copy and paste a formatted citation
Spandidos Publications style
Kim D, Du J, Miao C, Jung JH, Park SC and Kim D: The possible roles for polyamines in the initiation process of SV40 DNA replication in vitro. Oncol Rep 19: 535-539, 2008.
APA
Kim, D., Du, J., Miao, C., Jung, J.H., Park, S.C., & Kim, D. (2008). The possible roles for polyamines in the initiation process of SV40 DNA replication in vitro. Oncology Reports, 19, 535-539. https://doi.org/10.3892/or.19.2.535
MLA
Kim, D., Du, J., Miao, C., Jung, J. H., Park, S. C., Kim, D." The possible roles for polyamines in the initiation process of SV40 DNA replication in vitro". Oncology Reports 19.2 (2008): 535-539.
Chicago
Kim, D., Du, J., Miao, C., Jung, J. H., Park, S. C., Kim, D." The possible roles for polyamines in the initiation process of SV40 DNA replication in vitro". Oncology Reports 19, no. 2 (2008): 535-539. https://doi.org/10.3892/or.19.2.535
Copy and paste a formatted citation
x
Spandidos Publications style
Kim D, Du J, Miao C, Jung JH, Park SC and Kim D: The possible roles for polyamines in the initiation process of SV40 DNA replication in vitro. Oncol Rep 19: 535-539, 2008.
APA
Kim, D., Du, J., Miao, C., Jung, J.H., Park, S.C., & Kim, D. (2008). The possible roles for polyamines in the initiation process of SV40 DNA replication in vitro. Oncology Reports, 19, 535-539. https://doi.org/10.3892/or.19.2.535
MLA
Kim, D., Du, J., Miao, C., Jung, J. H., Park, S. C., Kim, D." The possible roles for polyamines in the initiation process of SV40 DNA replication in vitro". Oncology Reports 19.2 (2008): 535-539.
Chicago
Kim, D., Du, J., Miao, C., Jung, J. H., Park, S. C., Kim, D." The possible roles for polyamines in the initiation process of SV40 DNA replication in vitro". Oncology Reports 19, no. 2 (2008): 535-539. https://doi.org/10.3892/or.19.2.535
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