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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2008 Volume 19 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2008 Volume 19 Issue 2

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Article

Corn-derived carbohydrate inositol hexaphosphate inhibits Barrett's adenocarcinoma growth by pro-apoptotic mechanisms

  • Authors:
    • David W. McFadden
    • Dale R. Riggs
    • Barbara J. Jackson
    • Cynthia Cunningham

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Robert C. Byrd Health Science Center, West Virginia University, Morgantown, WV 26506, USA. david.mcfadden@vtmednet.org
  • Pages: 563-566
    |
    Published online on: February 1, 2008
       https://doi.org/10.3892/or.19.2.563
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Abstract

Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that is found in food sources high in fiber content. IP6 has been reported to have significant inhibitory effects against a variety of primary tumors. We hypothesized that IP6 would inhibit the cell growth rate of Barrett's adenocarcinoma in vitro. Two Barrett's-associated adenocarcinoma cell lines, SEG-1 and BIC-1, were treated with IP6 at 0.5, 1.0 and 5.0 mM concentrations. Cell viability was measured by MTT assay. Apoptosis and necrosis were evaluated by the Annexin V FITC assay. Reductions (P<0.001) in cellular proliferation were observed in both cell lines. IP6 decreased late apoptosis and necrosis in BIC cells, whereas in SEG-1 cells, early apoptosis, late apoptosis and necrosis were all increased by IP6. IP6 decreases cellular growth by pro-apoptotic mechanisms. Our findings suggest that IP6 has the potential to become an effective adjunct for Barrett's adenocarcinoma. Further studies are needed to evaluate safety and clinical utility of this agent in patients with Barrett's adenocarcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
McFadden DW, Riggs DR, Jackson BJ and Cunningham C: Corn-derived carbohydrate inositol hexaphosphate inhibits Barrett's adenocarcinoma growth by pro-apoptotic mechanisms. Oncol Rep 19: 563-566, 2008.
APA
McFadden, D.W., Riggs, D.R., Jackson, B.J., & Cunningham, C. (2008). Corn-derived carbohydrate inositol hexaphosphate inhibits Barrett's adenocarcinoma growth by pro-apoptotic mechanisms. Oncology Reports, 19, 563-566. https://doi.org/10.3892/or.19.2.563
MLA
McFadden, D. W., Riggs, D. R., Jackson, B. J., Cunningham, C."Corn-derived carbohydrate inositol hexaphosphate inhibits Barrett's adenocarcinoma growth by pro-apoptotic mechanisms". Oncology Reports 19.2 (2008): 563-566.
Chicago
McFadden, D. W., Riggs, D. R., Jackson, B. J., Cunningham, C."Corn-derived carbohydrate inositol hexaphosphate inhibits Barrett's adenocarcinoma growth by pro-apoptotic mechanisms". Oncology Reports 19, no. 2 (2008): 563-566. https://doi.org/10.3892/or.19.2.563
Copy and paste a formatted citation
x
Spandidos Publications style
McFadden DW, Riggs DR, Jackson BJ and Cunningham C: Corn-derived carbohydrate inositol hexaphosphate inhibits Barrett's adenocarcinoma growth by pro-apoptotic mechanisms. Oncol Rep 19: 563-566, 2008.
APA
McFadden, D.W., Riggs, D.R., Jackson, B.J., & Cunningham, C. (2008). Corn-derived carbohydrate inositol hexaphosphate inhibits Barrett's adenocarcinoma growth by pro-apoptotic mechanisms. Oncology Reports, 19, 563-566. https://doi.org/10.3892/or.19.2.563
MLA
McFadden, D. W., Riggs, D. R., Jackson, B. J., Cunningham, C."Corn-derived carbohydrate inositol hexaphosphate inhibits Barrett's adenocarcinoma growth by pro-apoptotic mechanisms". Oncology Reports 19.2 (2008): 563-566.
Chicago
McFadden, D. W., Riggs, D. R., Jackson, B. J., Cunningham, C."Corn-derived carbohydrate inositol hexaphosphate inhibits Barrett's adenocarcinoma growth by pro-apoptotic mechanisms". Oncology Reports 19, no. 2 (2008): 563-566. https://doi.org/10.3892/or.19.2.563
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