Myeloid leukemia-1 expression in benign and malignant melanocytic lesions

  • Authors:
    • Ronald P.C. Wong
    • Shahram Khosravi
    • Magdalena Martinka
    • Gang Li
  • View Affiliations

  • Published online on: April 1, 2008     https://doi.org/10.3892/or.19.4.933
  • Pages: 933-937
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Abstract

Myeloid leukemia-1 (Mcl-1) is an anti-apoptotic protein implicated in tumor progression. Its expression was found to be elevated in many types of human cancers and is correlated with tumor progression. The expression of Mcl-1 in melanoma is not fully understood. We investigated the expression of Mcl-1 in normal nevi, dysplastic nevi, primary melanoma and melanoma metastases by tissue microarray and immunohistochemistry. We found that Mcl-1 expression was significantly increased in dysplastic nevi, primary melanoma and melanoma metastases when compared to normal nevi, though the expression of Mcl-1 was decreased in metastatic melanoma when compared to dysplastic nevi. We did not find any correlation between Mcl-1 expression and melanoma patient survival. Our data suggest that Mcl-1 may play a critical role in the initiation of melanoma development.

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April 2008
Volume 19 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wong RP, Khosravi S, Martinka M and Li G: Myeloid leukemia-1 expression in benign and malignant melanocytic lesions. Oncol Rep 19: 933-937, 2008.
APA
Wong, R.P., Khosravi, S., Martinka, M., & Li, G. (2008). Myeloid leukemia-1 expression in benign and malignant melanocytic lesions. Oncology Reports, 19, 933-937. https://doi.org/10.3892/or.19.4.933
MLA
Wong, R. P., Khosravi, S., Martinka, M., Li, G."Myeloid leukemia-1 expression in benign and malignant melanocytic lesions". Oncology Reports 19.4 (2008): 933-937.
Chicago
Wong, R. P., Khosravi, S., Martinka, M., Li, G."Myeloid leukemia-1 expression in benign and malignant melanocytic lesions". Oncology Reports 19, no. 4 (2008): 933-937. https://doi.org/10.3892/or.19.4.933