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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2008 Volume 19 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Myeloid leukemia-1 expression in benign and malignant melanocytic lesions

  • Authors:
    • Ronald P.C. Wong
    • Shahram Khosravi
    • Magdalena Martinka
    • Gang Li
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology and Skin Science, Jack Bell Research Centre, British Columbia V6H 3Z6, Canada
  • Pages: 933-937
    |
    Published online on: April 1, 2008
       https://doi.org/10.3892/or.19.4.933
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Abstract

Myeloid leukemia-1 (Mcl-1) is an anti-apoptotic protein implicated in tumor progression. Its expression was found to be elevated in many types of human cancers and is correlated with tumor progression. The expression of Mcl-1 in melanoma is not fully understood. We investigated the expression of Mcl-1 in normal nevi, dysplastic nevi, primary melanoma and melanoma metastases by tissue microarray and immunohistochemistry. We found that Mcl-1 expression was significantly increased in dysplastic nevi, primary melanoma and melanoma metastases when compared to normal nevi, though the expression of Mcl-1 was decreased in metastatic melanoma when compared to dysplastic nevi. We did not find any correlation between Mcl-1 expression and melanoma patient survival. Our data suggest that Mcl-1 may play a critical role in the initiation of melanoma development.

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Copy and paste a formatted citation
Spandidos Publications style
Wong RP, Khosravi S, Martinka M and Li G: Myeloid leukemia-1 expression in benign and malignant melanocytic lesions. Oncol Rep 19: 933-937, 2008.
APA
Wong, R.P., Khosravi, S., Martinka, M., & Li, G. (2008). Myeloid leukemia-1 expression in benign and malignant melanocytic lesions. Oncology Reports, 19, 933-937. https://doi.org/10.3892/or.19.4.933
MLA
Wong, R. P., Khosravi, S., Martinka, M., Li, G."Myeloid leukemia-1 expression in benign and malignant melanocytic lesions". Oncology Reports 19.4 (2008): 933-937.
Chicago
Wong, R. P., Khosravi, S., Martinka, M., Li, G."Myeloid leukemia-1 expression in benign and malignant melanocytic lesions". Oncology Reports 19, no. 4 (2008): 933-937. https://doi.org/10.3892/or.19.4.933
Copy and paste a formatted citation
x
Spandidos Publications style
Wong RP, Khosravi S, Martinka M and Li G: Myeloid leukemia-1 expression in benign and malignant melanocytic lesions. Oncol Rep 19: 933-937, 2008.
APA
Wong, R.P., Khosravi, S., Martinka, M., & Li, G. (2008). Myeloid leukemia-1 expression in benign and malignant melanocytic lesions. Oncology Reports, 19, 933-937. https://doi.org/10.3892/or.19.4.933
MLA
Wong, R. P., Khosravi, S., Martinka, M., Li, G."Myeloid leukemia-1 expression in benign and malignant melanocytic lesions". Oncology Reports 19.4 (2008): 933-937.
Chicago
Wong, R. P., Khosravi, S., Martinka, M., Li, G."Myeloid leukemia-1 expression in benign and malignant melanocytic lesions". Oncology Reports 19, no. 4 (2008): 933-937. https://doi.org/10.3892/or.19.4.933
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