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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2008 Volume 19 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

A possible role of BDNF in prostate cancer detection

  • Authors:
    • E. Bronzetti
    • M. Artico
    • F. Forte
    • G. Pagliarella
    • L. M. Felici
    • A. D'Ambrosio
    • G. Vespasiani
    • B. Bronzetti

  • View Affiliations / Copyright

    Affiliations: ‘La Sapienza’ University of Rome, Department of Cardiovascular, Respiratory and Morphological Sciences, 00161 Rome, Italy. elena.bronzetti@uniroma1.it
  • Pages: 969-974
    |
    Published online on: April 1, 2008
       https://doi.org/10.3892/or.19.4.969
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Abstract

Many studies have demonstrated that both normal and malignant prostate cells respond to a variety of growth factors, while several significant differences were found between normal and tumoural cells. The aim of this study was to focus on the localization and distribution of the immuno-reactivity for neurotrophins (NTs) and neurotrophin receptors (NTRs) in normal, hyperplastic and prostate cancer cells, obtained from 40 subjects. We studied samples obtained from 16 prostate cancer (PC, retropubic radical prostatectomy), 20 benign prostatic hyperplasia (BPH, supra-pubic prostatectomy) and normal peripheral prostate tissue from four fresh male cadavers. Samples were examined via immunohistochemical techniques in order to detect the expression of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3) and their own receptors TrkA, p75, TrkB and TrkC. We observed a high expression of BDNF and TrkB in PC and BPH, though no immuno-reactivity was found for p75. Low expression was reported by other NTs and NTRs in the normal peripheral prostate zone, BPH and PC. These data suggest a possible predictive role for NTs and NTRs, especially for BDNF and TrkB, in the diagnosis and/or management of prostate cancer. The absence of p75 expression confirms its supposed role in apoptotic phenomenon.

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Copy and paste a formatted citation
Spandidos Publications style
Bronzetti E, Artico M, Forte F, Pagliarella G, Felici LM, D'Ambrosio A, Vespasiani G and Bronzetti B: A possible role of BDNF in prostate cancer detection. Oncol Rep 19: 969-974, 2008.
APA
Bronzetti, E., Artico, M., Forte, F., Pagliarella, G., Felici, L.M., D'Ambrosio, A. ... Bronzetti, B. (2008). A possible role of BDNF in prostate cancer detection. Oncology Reports, 19, 969-974. https://doi.org/10.3892/or.19.4.969
MLA
Bronzetti, E., Artico, M., Forte, F., Pagliarella, G., Felici, L. M., D'Ambrosio, A., Vespasiani, G., Bronzetti, B."A possible role of BDNF in prostate cancer detection". Oncology Reports 19.4 (2008): 969-974.
Chicago
Bronzetti, E., Artico, M., Forte, F., Pagliarella, G., Felici, L. M., D'Ambrosio, A., Vespasiani, G., Bronzetti, B."A possible role of BDNF in prostate cancer detection". Oncology Reports 19, no. 4 (2008): 969-974. https://doi.org/10.3892/or.19.4.969
Copy and paste a formatted citation
x
Spandidos Publications style
Bronzetti E, Artico M, Forte F, Pagliarella G, Felici LM, D'Ambrosio A, Vespasiani G and Bronzetti B: A possible role of BDNF in prostate cancer detection. Oncol Rep 19: 969-974, 2008.
APA
Bronzetti, E., Artico, M., Forte, F., Pagliarella, G., Felici, L.M., D'Ambrosio, A. ... Bronzetti, B. (2008). A possible role of BDNF in prostate cancer detection. Oncology Reports, 19, 969-974. https://doi.org/10.3892/or.19.4.969
MLA
Bronzetti, E., Artico, M., Forte, F., Pagliarella, G., Felici, L. M., D'Ambrosio, A., Vespasiani, G., Bronzetti, B."A possible role of BDNF in prostate cancer detection". Oncology Reports 19.4 (2008): 969-974.
Chicago
Bronzetti, E., Artico, M., Forte, F., Pagliarella, G., Felici, L. M., D'Ambrosio, A., Vespasiani, G., Bronzetti, B."A possible role of BDNF in prostate cancer detection". Oncology Reports 19, no. 4 (2008): 969-974. https://doi.org/10.3892/or.19.4.969
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