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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2008 Volume 19 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene

  • Authors:
    • Hironobu Hata
    • Tetsuya Kitamura
    • Fumihiro Higashino
    • Kyoko Hida
    • Koichi Yoshida
    • Yoichi Ohiro
    • Yasunori Totsuka
    • Yoshimasa Kitagawa
    • Masanobu Shindoh

  • View Affiliations / Copyright

    Affiliations: Department of Oral Pathology and Biology, Hokkaido University Graduate School of Dental Medicine, Sapporo 060-8586, Japan
  • Pages: 1093-1098
    |
    Published online on: May 1, 2008
       https://doi.org/10.3892/or.19.5.1093
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Abstract

Matrix metalloproteinase (MMP) is closely involved in the degradation of extracellular matrix and confers invasive and metastatic potential to malignant tumors. MMP-2 is a type-IV collagenase secreted as a proenzyme that is activated on the surface of the tumor cell by membrane-type 1-MMP (MT1-MMP). MT1-MMP plays a critical role during tumor progression and metastasis. We investigated the expression levels of E1AF and MT1-MMP in malignant melanoma cell lines and specimens from patients in order to clarify the mechanisms responsible for the invasion and metastasis of malignant melanoma. High levels of E1AF and MT1-MMP mRNA expression were observed in melanoma cells by Northern blotting and real-time PCR. The expression level was highly correlated with an invasive potential determined by an in vitro invasion assay. The down-regulation of MT1-MMP was identified when E1AF was knocked down by RNA interference. These results suggest that E1AF plays a crucial role in the invasion and metastasis of malignant melanoma through up-regulating the MT1-MMP expression.

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Copy and paste a formatted citation
Spandidos Publications style
Hata H, Kitamura T, Higashino F, Hida K, Yoshida K, Ohiro Y, Totsuka Y, Kitagawa Y and Shindoh M: Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene. Oncol Rep 19: 1093-1098, 2008.
APA
Hata, H., Kitamura, T., Higashino, F., Hida, K., Yoshida, K., Ohiro, Y. ... Shindoh, M. (2008). Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene. Oncology Reports, 19, 1093-1098. https://doi.org/10.3892/or.19.5.1093
MLA
Hata, H., Kitamura, T., Higashino, F., Hida, K., Yoshida, K., Ohiro, Y., Totsuka, Y., Kitagawa, Y., Shindoh, M."Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene". Oncology Reports 19.5 (2008): 1093-1098.
Chicago
Hata, H., Kitamura, T., Higashino, F., Hida, K., Yoshida, K., Ohiro, Y., Totsuka, Y., Kitagawa, Y., Shindoh, M."Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene". Oncology Reports 19, no. 5 (2008): 1093-1098. https://doi.org/10.3892/or.19.5.1093
Copy and paste a formatted citation
x
Spandidos Publications style
Hata H, Kitamura T, Higashino F, Hida K, Yoshida K, Ohiro Y, Totsuka Y, Kitagawa Y and Shindoh M: Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene. Oncol Rep 19: 1093-1098, 2008.
APA
Hata, H., Kitamura, T., Higashino, F., Hida, K., Yoshida, K., Ohiro, Y. ... Shindoh, M. (2008). Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene. Oncology Reports, 19, 1093-1098. https://doi.org/10.3892/or.19.5.1093
MLA
Hata, H., Kitamura, T., Higashino, F., Hida, K., Yoshida, K., Ohiro, Y., Totsuka, Y., Kitagawa, Y., Shindoh, M."Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene". Oncology Reports 19.5 (2008): 1093-1098.
Chicago
Hata, H., Kitamura, T., Higashino, F., Hida, K., Yoshida, K., Ohiro, Y., Totsuka, Y., Kitagawa, Y., Shindoh, M."Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene". Oncology Reports 19, no. 5 (2008): 1093-1098. https://doi.org/10.3892/or.19.5.1093
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