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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2008 Volume 19 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2008 Volume 19 Issue 5

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Article

Clodronate inhibits angiogenesis in vitro and in vivo

  • Authors:
    • D. Ribatti
    • N. Maruotti
    • B. Nico
    • V. Longo
    • D. Mangieri
    • A. Vacca
    • F. P. Cantatore

  • View Affiliations / Copyright

    Affiliations: Department of Human Anatomy and Histology, Policlinico, I-70124 Bari, Italy. ribatti@anatomia.uniba.it
  • Pages: 1109-1112
    |
    Published online on: May 1, 2008
       https://doi.org/10.3892/or.19.5.1109
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Abstract

The effects of amino-bisphosphonate clodronate on endothelial cell functions involved in angiogenesis, namely proliferation and morphogenesis on matrigel were tested in vitro, whereas its effects on angiogenesis were studied in vivo. This was performed by using the chick embryo chorioallantoic membrane (CAM) assay. In vitro, clodronate inhibited the endothelial cell proliferation in a dose-dependent fashion, peaking at 30 µM. At the same concentration, clodronate inhibited the fibroblast growth factor-2 (FGF-2)-induced capillary-like tube formation in the morphogenesis assay on matrigel. In vivo, when tested with the CAM assay, clodronate again displayed the capability to inhibit FGF-2-induced angiogenesis. Overall, these results suggest that antiangiogenesis by clodronate can be used to treat a wide spectrum of angiogenesis-dependent diseases, including certain chronic inflammatory diseases and cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Ribatti D, Maruotti N, Nico B, Longo V, Mangieri D, Vacca A and Cantatore FP: Clodronate inhibits angiogenesis in vitro and in vivo. Oncol Rep 19: 1109-1112, 2008.
APA
Ribatti, D., Maruotti, N., Nico, B., Longo, V., Mangieri, D., Vacca, A., & Cantatore, F.P. (2008). Clodronate inhibits angiogenesis in vitro and in vivo. Oncology Reports, 19, 1109-1112. https://doi.org/10.3892/or.19.5.1109
MLA
Ribatti, D., Maruotti, N., Nico, B., Longo, V., Mangieri, D., Vacca, A., Cantatore, F. P."Clodronate inhibits angiogenesis in vitro and in vivo". Oncology Reports 19.5 (2008): 1109-1112.
Chicago
Ribatti, D., Maruotti, N., Nico, B., Longo, V., Mangieri, D., Vacca, A., Cantatore, F. P."Clodronate inhibits angiogenesis in vitro and in vivo". Oncology Reports 19, no. 5 (2008): 1109-1112. https://doi.org/10.3892/or.19.5.1109
Copy and paste a formatted citation
x
Spandidos Publications style
Ribatti D, Maruotti N, Nico B, Longo V, Mangieri D, Vacca A and Cantatore FP: Clodronate inhibits angiogenesis in vitro and in vivo. Oncol Rep 19: 1109-1112, 2008.
APA
Ribatti, D., Maruotti, N., Nico, B., Longo, V., Mangieri, D., Vacca, A., & Cantatore, F.P. (2008). Clodronate inhibits angiogenesis in vitro and in vivo. Oncology Reports, 19, 1109-1112. https://doi.org/10.3892/or.19.5.1109
MLA
Ribatti, D., Maruotti, N., Nico, B., Longo, V., Mangieri, D., Vacca, A., Cantatore, F. P."Clodronate inhibits angiogenesis in vitro and in vivo". Oncology Reports 19.5 (2008): 1109-1112.
Chicago
Ribatti, D., Maruotti, N., Nico, B., Longo, V., Mangieri, D., Vacca, A., Cantatore, F. P."Clodronate inhibits angiogenesis in vitro and in vivo". Oncology Reports 19, no. 5 (2008): 1109-1112. https://doi.org/10.3892/or.19.5.1109
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