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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2008 Volume 19 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2008 Volume 19 Issue 5

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Article

New insight into the key proteins and pathways involved in the metastasis of colorectal carcinoma

  • Authors:
    • Guan-Zhen Yu
    • Ying Chen
    • Ya-Qiu Long
    • Dong Dong
    • Xiao-Lan Mu
    • Jie-Jun Wang

  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Changzheng Hospital, Shanghai, P.R. China
  • Pages: 1191-1204
    |
    Published online on: May 1, 2008
       https://doi.org/10.3892/or.19.5.1191
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Abstract

Metastasis-associated genomic alterations have been recognized to play a critical role in tumor metastasis. Primary and metastatic tumor cells in mice and tumors in a patient were studied by cDNA array analysis. Selected genes were determined by RT-PCR and immunohistochemistry. Pathways on changed genes were statistically analyzed. The function of Grb2 was determined by in vitro wound assay. Nodal metastatic cells had a stronger ability of growth and metastasis than primary tumor cells. A total of 376 genes showed a different expression between primary and metastatic cells. The expression of Grb2 and genes in the Grb2-mediated pathways was significantly elevated in the metastases. Elevated levels of Grb2 expression in metastases were related to the distant metastasis of colorectal carcinoma. Blocking the Grb2-SH2 domain signaling transduction inhibited cell motility. Metastasis-associated genes identified by cDNA and tissue microarrays provide potentially valuable information on the metastasis of colorectal tumors. Overexpression of Grb2 may contribute to tumor growth, invasiveness and metastasis.

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Copy and paste a formatted citation
Spandidos Publications style
Yu G, Chen Y, Long Y, Dong D, Mu X and Wang J: New insight into the key proteins and pathways involved in the metastasis of colorectal carcinoma. Oncol Rep 19: 1191-1204, 2008.
APA
Yu, G., Chen, Y., Long, Y., Dong, D., Mu, X., & Wang, J. (2008). New insight into the key proteins and pathways involved in the metastasis of colorectal carcinoma. Oncology Reports, 19, 1191-1204. https://doi.org/10.3892/or.19.5.1191
MLA
Yu, G., Chen, Y., Long, Y., Dong, D., Mu, X., Wang, J."New insight into the key proteins and pathways involved in the metastasis of colorectal carcinoma". Oncology Reports 19.5 (2008): 1191-1204.
Chicago
Yu, G., Chen, Y., Long, Y., Dong, D., Mu, X., Wang, J."New insight into the key proteins and pathways involved in the metastasis of colorectal carcinoma". Oncology Reports 19, no. 5 (2008): 1191-1204. https://doi.org/10.3892/or.19.5.1191
Copy and paste a formatted citation
x
Spandidos Publications style
Yu G, Chen Y, Long Y, Dong D, Mu X and Wang J: New insight into the key proteins and pathways involved in the metastasis of colorectal carcinoma. Oncol Rep 19: 1191-1204, 2008.
APA
Yu, G., Chen, Y., Long, Y., Dong, D., Mu, X., & Wang, J. (2008). New insight into the key proteins and pathways involved in the metastasis of colorectal carcinoma. Oncology Reports, 19, 1191-1204. https://doi.org/10.3892/or.19.5.1191
MLA
Yu, G., Chen, Y., Long, Y., Dong, D., Mu, X., Wang, J."New insight into the key proteins and pathways involved in the metastasis of colorectal carcinoma". Oncology Reports 19.5 (2008): 1191-1204.
Chicago
Yu, G., Chen, Y., Long, Y., Dong, D., Mu, X., Wang, J."New insight into the key proteins and pathways involved in the metastasis of colorectal carcinoma". Oncology Reports 19, no. 5 (2008): 1191-1204. https://doi.org/10.3892/or.19.5.1191
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