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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2008 Volume 19 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Fluorescent in situ hybridization as a screening test for HER2 amplification in G2 and G3 breast cancers of lobular and ductal histotype and metastases

  • Authors:
    • Isabella Castellano
    • Anna Sapino
    • Riccardo Arisio
    • Giuseppe Viale
    • Gianni Bussolati
    • Roberto Bandelloni
    • Gaetano Barresi
    • Alessandra Bersiga
    • Cesare Bordi
    • Gerardo Botti
    • Fabia Cosimi
    • Emanuele D'Amore
    • Claudio Doglioni
    • Antonio Marchetti
    • Oscar Nappi
    • Francesco Romeo
    • Massimo Roncalli
    • Rosa Russo
    • Alfredo Santinelli
    • Luigi Giusto Spagnoli
    • Francesco Tanda
    • Paolo Tricomi
    • Gianpaolo Trentini
    • Fabrizio Zanconati
    • Monica Iurlaro
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Sciences and Human Oncology, University of Turin, 10126 Turin, Italy
  • Pages: 1271-1275
    |
    Published online on: May 1, 2008
       https://doi.org/10.3892/or.19.5.1271
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Abstract

The aim of the present study was to evaluate the effectiveness of fluorescence in situ hybridisation (FISH), as a screening test, in moderately- (G2) or poorly- (G3) differentiated breast cancers of the ductal (IDC) and lobular (ILC) histotypes and distant metastases. HER2 FISH was performed on 486 G2 and 477 G3 both of IDC and ILC histotypes and in 241 metastases. A significant difference in the HER2 amplification was observed between G2 (14.8%) and G3 (31.9%), with no difference according to the histotype. However, the rate of amplification increased to 36% in the G2/hormone receptor-negative cases as compared to 10.6% in the G2/receptor-positive cases (p<0.0001). HER2 was amplified in 17% of metastases with some differences depending on the location. These data suggest that the HER2 FISH analysis may be an effective screening test in breast cancer metastases and G3 tumors, irrespective of the hormone receptor status or presence of lymphovascular invasion.

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Copy and paste a formatted citation
Spandidos Publications style
Castellano I, Sapino A, Arisio R, Viale G, Bussolati G, Bandelloni R, Barresi G, Bersiga A, Bordi C, Botti G, Botti G, et al: Fluorescent in situ hybridization as a screening test for HER2 amplification in G2 and G3 breast cancers of lobular and ductal histotype and metastases. Oncol Rep 19: 1271-1275, 2008.
APA
Castellano, I., Sapino, A., Arisio, R., Viale, G., Bussolati, G., Bandelloni, R. ... Iurlaro, M. (2008). Fluorescent in situ hybridization as a screening test for HER2 amplification in G2 and G3 breast cancers of lobular and ductal histotype and metastases. Oncology Reports, 19, 1271-1275. https://doi.org/10.3892/or.19.5.1271
MLA
Castellano, I., Sapino, A., Arisio, R., Viale, G., Bussolati, G., Bandelloni, R., Barresi, G., Bersiga, A., Bordi, C., Botti, G., Cosimi, F., D'Amore, E., Doglioni, C., Marchetti, A., Nappi, O., Romeo, F., Roncalli, M., Russo, R., Santinelli, A., Spagnoli, L. G., Tanda, F., Tricomi, P., Trentini, G., Zanconati, F., Iurlaro, M."Fluorescent in situ hybridization as a screening test for HER2 amplification in G2 and G3 breast cancers of lobular and ductal histotype and metastases". Oncology Reports 19.5 (2008): 1271-1275.
Chicago
Castellano, I., Sapino, A., Arisio, R., Viale, G., Bussolati, G., Bandelloni, R., Barresi, G., Bersiga, A., Bordi, C., Botti, G., Cosimi, F., D'Amore, E., Doglioni, C., Marchetti, A., Nappi, O., Romeo, F., Roncalli, M., Russo, R., Santinelli, A., Spagnoli, L. G., Tanda, F., Tricomi, P., Trentini, G., Zanconati, F., Iurlaro, M."Fluorescent in situ hybridization as a screening test for HER2 amplification in G2 and G3 breast cancers of lobular and ductal histotype and metastases". Oncology Reports 19, no. 5 (2008): 1271-1275. https://doi.org/10.3892/or.19.5.1271
Copy and paste a formatted citation
x
Spandidos Publications style
Castellano I, Sapino A, Arisio R, Viale G, Bussolati G, Bandelloni R, Barresi G, Bersiga A, Bordi C, Botti G, Botti G, et al: Fluorescent in situ hybridization as a screening test for HER2 amplification in G2 and G3 breast cancers of lobular and ductal histotype and metastases. Oncol Rep 19: 1271-1275, 2008.
APA
Castellano, I., Sapino, A., Arisio, R., Viale, G., Bussolati, G., Bandelloni, R. ... Iurlaro, M. (2008). Fluorescent in situ hybridization as a screening test for HER2 amplification in G2 and G3 breast cancers of lobular and ductal histotype and metastases. Oncology Reports, 19, 1271-1275. https://doi.org/10.3892/or.19.5.1271
MLA
Castellano, I., Sapino, A., Arisio, R., Viale, G., Bussolati, G., Bandelloni, R., Barresi, G., Bersiga, A., Bordi, C., Botti, G., Cosimi, F., D'Amore, E., Doglioni, C., Marchetti, A., Nappi, O., Romeo, F., Roncalli, M., Russo, R., Santinelli, A., Spagnoli, L. G., Tanda, F., Tricomi, P., Trentini, G., Zanconati, F., Iurlaro, M."Fluorescent in situ hybridization as a screening test for HER2 amplification in G2 and G3 breast cancers of lobular and ductal histotype and metastases". Oncology Reports 19.5 (2008): 1271-1275.
Chicago
Castellano, I., Sapino, A., Arisio, R., Viale, G., Bussolati, G., Bandelloni, R., Barresi, G., Bersiga, A., Bordi, C., Botti, G., Cosimi, F., D'Amore, E., Doglioni, C., Marchetti, A., Nappi, O., Romeo, F., Roncalli, M., Russo, R., Santinelli, A., Spagnoli, L. G., Tanda, F., Tricomi, P., Trentini, G., Zanconati, F., Iurlaro, M."Fluorescent in situ hybridization as a screening test for HER2 amplification in G2 and G3 breast cancers of lobular and ductal histotype and metastases". Oncology Reports 19, no. 5 (2008): 1271-1275. https://doi.org/10.3892/or.19.5.1271
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