Polymorphisms in CYP1B1, GSTM1, GSTT1 and GSTP1, and susceptibility to breast cancer

  • Authors:
    • Beth O. Van Emburgh
    • Jennifer J. Hu
    • Edward A. Levine
    • Libyadda J. Mosley
    • Nancy D. Perrier
    • Rita I. Freimanis
    • Glenn O. Allen
    • Peter Rubin
    • Gary B. Sherrill
    • Cindy S. Shaw
    • Lisa A. Carey
    • Lynda R. Sawyer
    • Mark Steven Miller
  • View Affiliations

  • Published online on: May 1, 2008     https://doi.org/10.3892/or.19.5.1311
  • Pages: 1311-1321
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Abstract

Polymorphisms in the cytochrome P450 1B1 (CYP1B1) and glutathione S-transferase (GST) drug metabolic enzymes, which are responsible for metabolic activation/detoxification of estrogen and environmental carcinogens, were analyzed for their association with breast cancer risk in 541 cases and 635 controls from a North Carolina population. Each polymorphism, altering the catalytic function of their respective enzymes, was analyzed in Caucasian and African-American women. As reported in previous studies, individual polymorphisms did not significantly impact breast cancer risk in either Caucasian or African-American women. However, African-American women exhibited a trend towards a protective effect when they had at least one CYP1B1 119S allele (OR=0.53; 95% CI=0.20-1.40) and increased risk for those women harboring at least one CYP1B1 432V allele (OR=5.52; 95% CI=0.50-61.37). Stratified analyses demonstrated significant interactions in younger (age ≤60) Caucasian women with the CYP1B1 119SS genotype (OR=3.09; 95% CI=1.22-7.84) and younger African-American women with the GSTT1 null genotype (OR=4.07; 95% CI=1.12-14.80). A notable trend was also found in Caucasian women with a history of smoking and at least one valine allele at GSTP1 114 (OR=2.12; 95% CI=1.02-4.41). In Caucasian women, the combined GSTP1 105IV/VV and CYP1B1 119AA genotypes resulted in a near 2-fold increase in risk (OR=1.96; 95% CI=1.04-3.72) and the three way combination of GSTP1 105IV/VV, CYP1B1 119AS/SS and GSTT1 null genotypes resulted in an almost 4-fold increase in risk (OR=3.97; 95% CI=1.27-12.40). These results suggest the importance of estrogen/carcinogen metabolic enzymes in the etiology of breast cancer, especially in women before the age of 60, as well as preventative measures such as smoking cessation.

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May 2008
Volume 19 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Van Emburgh BO, Hu JJ, Levine EA, Mosley LJ, Perrier ND, Freimanis RI, Allen GO, Rubin P, Sherrill GB, Shaw CS, Shaw CS, et al: Polymorphisms in CYP1B1, GSTM1, GSTT1 and GSTP1, and susceptibility to breast cancer. Oncol Rep 19: 1311-1321, 2008
APA
Van Emburgh, B.O., Hu, J.J., Levine, E.A., Mosley, L.J., Perrier, N.D., Freimanis, R.I. ... Miller, M.S. (2008). Polymorphisms in CYP1B1, GSTM1, GSTT1 and GSTP1, and susceptibility to breast cancer. Oncology Reports, 19, 1311-1321. https://doi.org/10.3892/or.19.5.1311
MLA
Van Emburgh, B. O., Hu, J. J., Levine, E. A., Mosley, L. J., Perrier, N. D., Freimanis, R. I., Allen, G. O., Rubin, P., Sherrill, G. B., Shaw, C. S., Carey, L. A., Sawyer, L. R., Miller, M. S."Polymorphisms in CYP1B1, GSTM1, GSTT1 and GSTP1, and susceptibility to breast cancer". Oncology Reports 19.5 (2008): 1311-1321.
Chicago
Van Emburgh, B. O., Hu, J. J., Levine, E. A., Mosley, L. J., Perrier, N. D., Freimanis, R. I., Allen, G. O., Rubin, P., Sherrill, G. B., Shaw, C. S., Carey, L. A., Sawyer, L. R., Miller, M. S."Polymorphisms in CYP1B1, GSTM1, GSTT1 and GSTP1, and susceptibility to breast cancer". Oncology Reports 19, no. 5 (2008): 1311-1321. https://doi.org/10.3892/or.19.5.1311