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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2008 Volume 19 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer

Expression of Concern in: /10.3892/or.2025.9028
  • Authors:
    • Rebecca Ching-Yu Leung
    • Stephanie Si Liu
    • Kelvin Yuen-Kwong Chan
    • Kar-Fai Tam
    • Kar-Loen Chan
    • Ling-Chui Wong
    • Hextan Yuen-Sheung Ngan

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, P.R. China
  • Pages: 1339-1345
    |
    Published online on: May 1, 2008
       https://doi.org/10.3892/or.19.5.1339
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Abstract

This study was aimed at investigating the death-associated protein kinase (DAPK) promoter methylation and its clinical relevance in cervical cancer. The DAPK promoter methylation was detected by methylation-specific PCR (MSP) and correlated with DAPK mRNA and protein expression. The effect of DAPK expression on the radiosensitivity of the cervical cancer cell line was assessed by overexpressing DAPK in the radioresistant cell line SiHa. DAPK hypermethylation was found in 56.08% of the cervical cancer samples and was associated with the tumor histological cell type of squamous cell carcinoma (p=0.002) and advanced tumor stage (p=0.005). Subsequently, DAPK protein expression was found to significantly decrease in cervical cancer samples when compared to normal tissues. The DAPK mRNA and protein expression levels were absent or remarkably reduced in SiHa and HeLa in which the DAPK promoter was hypermethylated. The expression levels of DAPK could be restored after demethylation treatment with 5-aza-2'-deoxycytidine. Overexpressing DAPK in vitro had no significant influence to the survival of the radioresistant SiHa cell after being challenged by irradiation. Our findings suggest that DAPK might not directly be responsible for the cellular radiosensitivity, however, DAPK hypermethylation appeared to be of prognostic significance in the advanced stages of cervical cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Leung RC, Liu SS, Chan KY, Tam K, Chan K, Wong L and Ngan HY: Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer Expression of Concern in /10.3892/or.2025.9028. Oncol Rep 19: 1339-1345, 2008.
APA
Leung, R.C., Liu, S.S., Chan, K.Y., Tam, K., Chan, K., Wong, L., & Ngan, H.Y. (2008). Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer Expression of Concern in /10.3892/or.2025.9028. Oncology Reports, 19, 1339-1345. https://doi.org/10.3892/or.19.5.1339
MLA
Leung, R. C., Liu, S. S., Chan, K. Y., Tam, K., Chan, K., Wong, L., Ngan, H. Y."Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer Expression of Concern in /10.3892/or.2025.9028". Oncology Reports 19.5 (2008): 1339-1345.
Chicago
Leung, R. C., Liu, S. S., Chan, K. Y., Tam, K., Chan, K., Wong, L., Ngan, H. Y."Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer Expression of Concern in /10.3892/or.2025.9028". Oncology Reports 19, no. 5 (2008): 1339-1345. https://doi.org/10.3892/or.19.5.1339
Copy and paste a formatted citation
x
Spandidos Publications style
Leung RC, Liu SS, Chan KY, Tam K, Chan K, Wong L and Ngan HY: Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer Expression of Concern in /10.3892/or.2025.9028. Oncol Rep 19: 1339-1345, 2008.
APA
Leung, R.C., Liu, S.S., Chan, K.Y., Tam, K., Chan, K., Wong, L., & Ngan, H.Y. (2008). Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer Expression of Concern in /10.3892/or.2025.9028. Oncology Reports, 19, 1339-1345. https://doi.org/10.3892/or.19.5.1339
MLA
Leung, R. C., Liu, S. S., Chan, K. Y., Tam, K., Chan, K., Wong, L., Ngan, H. Y."Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer Expression of Concern in /10.3892/or.2025.9028". Oncology Reports 19.5 (2008): 1339-1345.
Chicago
Leung, R. C., Liu, S. S., Chan, K. Y., Tam, K., Chan, K., Wong, L., Ngan, H. Y."Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer Expression of Concern in /10.3892/or.2025.9028". Oncology Reports 19, no. 5 (2008): 1339-1345. https://doi.org/10.3892/or.19.5.1339
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