CI-994 (N-acetyl-dinaline) in combination with conventional anti-cancer agents is effective against acute myeloid leukemia in vitro and in vivo

  • Authors:
    • I. Hubeek
    • E. M. Comijn
    • C. L. Van der Wilt
    • R. L. Merriman
    • J. M. Padron
    • G. J.L. Kaspers
    • G. J. Peters
  • View Affiliations

  • Published online on: June 1, 2008     https://doi.org/10.3892/or.19.6.1517
  • Pages: 1517-1523
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Abstract

N-acetyl-dinaline (CI-994) is an investigational anti-cancer drug which inhibits histone deacetylases. We evaluated the interaction between CI-994 and conventional chemotherapeutics used in acute myeloid leukemia (AML) in a rat model for AML and Brown Norway rat acute myelocytic leukemia (BNML). In vitro, CI-994 in combination with cytarabine (ara-C), daunorubicin and mitoxantrone, resulted in moderate synergism. In vivo, higher dosages of CI-994 induced complete remissions. CI-994/ara-C was very active against BNML. The combinations of CI-994/daunorubicin and CI-994/mitoxantrone were also active against BNML. This study demonstrates favorable in vitro and in vivo interactions between CI-994 and conventional anti-cancer agents used for the treatment of AML.

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June 2008
Volume 19 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hubeek I, Comijn EM, Van der Wilt CL, Merriman RL, Padron JM, Kaspers GJ and Peters GJ: CI-994 (N-acetyl-dinaline) in combination with conventional anti-cancer agents is effective against acute myeloid leukemia in vitro and in vivo. Oncol Rep 19: 1517-1523, 2008
APA
Hubeek, I., Comijn, E.M., Van der Wilt, C.L., Merriman, R.L., Padron, J.M., Kaspers, G.J., & Peters, G.J. (2008). CI-994 (N-acetyl-dinaline) in combination with conventional anti-cancer agents is effective against acute myeloid leukemia in vitro and in vivo. Oncology Reports, 19, 1517-1523. https://doi.org/10.3892/or.19.6.1517
MLA
Hubeek, I., Comijn, E. M., Van der Wilt, C. L., Merriman, R. L., Padron, J. M., Kaspers, G. J., Peters, G. J."CI-994 (N-acetyl-dinaline) in combination with conventional anti-cancer agents is effective against acute myeloid leukemia in vitro and in vivo". Oncology Reports 19.6 (2008): 1517-1523.
Chicago
Hubeek, I., Comijn, E. M., Van der Wilt, C. L., Merriman, R. L., Padron, J. M., Kaspers, G. J., Peters, G. J."CI-994 (N-acetyl-dinaline) in combination with conventional anti-cancer agents is effective against acute myeloid leukemia in vitro and in vivo". Oncology Reports 19, no. 6 (2008): 1517-1523. https://doi.org/10.3892/or.19.6.1517