Evaluation of lung lesions using FDG γ-camera PET equipped with a one-inch crystal

  • Authors:
    • Hong-Wei Zhan
    • Hai-Feng Cheng
    • Xiao-Juan Ye
    • Chun-Lei Zhao
    • Hong Zhang
    • Hong-Biao Liu
    • Gang-Qiang He
  • View Affiliations

  • Published online on: July 1, 2008     https://doi.org/10.3892/or.20.1.173
  • Pages: 173-178
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Abstract

The aim of this study was to evaluate the clinical value of 18-fluorodeoxyglucose (FDG) imaging with γ-camera positron emission tomography (GCPET) equipped with a one-inch crystal for diagnosing lung lesions and determining the stage of non-small cell lung cancer (NSCLC) in regions with a high prevalence of inflammatory disease and tuberculosis. FDG-GCPET was used to examine 103 patients with suspected malignant lesions in the lung. The results of FDG-GCPET and conventional workup (CWU) including computed tomography (CT), ultrasonography and radionuclide bone scintigraphy were compared. The final diagnosis was based on the results of a histological analysis or follow-up of at least six months. The results showed 82 patients with malignant and 21 patients with benign lesions. If a lesion to background ratio ≥2.0 was used as the threshold, then the diagnostic sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of FDG-GCPET for NSCLC were 93.9, 57.1, 86.4, 89.5 and 70.6%, respectively. In 36 patients who underwent open-chest surgery, the diagnostic positive values of FDG-GCPET and CT for lymph-node involvement were 85% (17/20) and 65% (13/20), respectively. The diagnostic sensitivity, specificity, accuracy, PPV and NPV of FDG imaging were 85, 81.3, 83.3, 85 and 81.3%, respectively compared to the CT values of 65, 75, 69.4, 76.5 and 63.2%, respectively (NS). For the evaluation of distant metastases, 31 true-positive patients were identified during the follow-up. FDG imaging correctly identified 28 patients compared to 25 by CWU. In conclusion, FDG imaging with GCPET equipped with a one-inch crystal revealed a high lesion detection capability but a low level of clinical effectiveness for differentiating between malignant and benign lesions in the lung in regions with a high prevalence of inflammatory disease and tuberculosis. For N and M staging of NSCLC, this method may provide additional data that are not available from the CWU.

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July 2008
Volume 20 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zhan H, Cheng H, Ye X, Zhao C, Zhang H, Liu H and He G: Evaluation of lung lesions using FDG γ-camera PET equipped with a one-inch crystal. Oncol Rep 20: 173-178, 2008.
APA
Zhan, H., Cheng, H., Ye, X., Zhao, C., Zhang, H., Liu, H., & He, G. (2008). Evaluation of lung lesions using FDG γ-camera PET equipped with a one-inch crystal. Oncology Reports, 20, 173-178. https://doi.org/10.3892/or.20.1.173
MLA
Zhan, H., Cheng, H., Ye, X., Zhao, C., Zhang, H., Liu, H., He, G."Evaluation of lung lesions using FDG γ-camera PET equipped with a one-inch crystal". Oncology Reports 20.1 (2008): 173-178.
Chicago
Zhan, H., Cheng, H., Ye, X., Zhao, C., Zhang, H., Liu, H., He, G."Evaluation of lung lesions using FDG γ-camera PET equipped with a one-inch crystal". Oncology Reports 20, no. 1 (2008): 173-178. https://doi.org/10.3892/or.20.1.173