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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2011 Volume 25 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells

  • Authors:
    • Chan Zhu
    • Yuqin Pan
    • Bangshun He
    • Bo Wang
    • Yongfei Xu
    • Lili Qu
    • Qian Bao
    • Fuliang Tian
    • Shukui Wang

  • View Affiliations / Copyright

    Affiliations: Department of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210046, P.R. China, Central Laboratory of Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210012, P.R. China
  • Pages: 425-432
    |
    Published online on: December 9, 2010
       https://doi.org/10.3892/or.2010.1088
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Abstract

CD147, also named extracelluar matrix metalloproteinase inducer (EMMPRIN), is a member of the immunoglobulin family and a glycoprotein enriched on the surface of tumor cells, which promotes invasion, metastasis, growth and survival of malignant cells, and is known to confer resistance to some chemotherapeutic drugs. To determine the possible role of CD147 in the invasive properties of laryngeal carcinoma, we used an RNA interference approach to silence CD147 expression in the Hep2 cell line at high levels of CD147 expression. Our results showed that CD147 expression was significantly impeded at both mRNA and protein levels, which resulted in a decrease of the Hep2 invasion activity in vitro and tumorigenicity in nude mice. The suppression of CD147 expression also sensitized cells to cisplatin. Our current results indicated that CD147 was a laryngeal carcinoma-related gene and CD147 might be a potential target for therapeutic anti-cancer drugs.

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Copy and paste a formatted citation
Spandidos Publications style
Zhu C, Pan Y, He B, Wang B, Xu Y, Qu L, Bao Q, Tian F and Wang S: Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells. Oncol Rep 25: 425-432, 2011.
APA
Zhu, C., Pan, Y., He, B., Wang, B., Xu, Y., Qu, L. ... Wang, S. (2011). Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells. Oncology Reports, 25, 425-432. https://doi.org/10.3892/or.2010.1088
MLA
Zhu, C., Pan, Y., He, B., Wang, B., Xu, Y., Qu, L., Bao, Q., Tian, F., Wang, S."Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells". Oncology Reports 25.2 (2011): 425-432.
Chicago
Zhu, C., Pan, Y., He, B., Wang, B., Xu, Y., Qu, L., Bao, Q., Tian, F., Wang, S."Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells". Oncology Reports 25, no. 2 (2011): 425-432. https://doi.org/10.3892/or.2010.1088
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu C, Pan Y, He B, Wang B, Xu Y, Qu L, Bao Q, Tian F and Wang S: Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells. Oncol Rep 25: 425-432, 2011.
APA
Zhu, C., Pan, Y., He, B., Wang, B., Xu, Y., Qu, L. ... Wang, S. (2011). Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells. Oncology Reports, 25, 425-432. https://doi.org/10.3892/or.2010.1088
MLA
Zhu, C., Pan, Y., He, B., Wang, B., Xu, Y., Qu, L., Bao, Q., Tian, F., Wang, S."Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells". Oncology Reports 25.2 (2011): 425-432.
Chicago
Zhu, C., Pan, Y., He, B., Wang, B., Xu, Y., Qu, L., Bao, Q., Tian, F., Wang, S."Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells". Oncology Reports 25, no. 2 (2011): 425-432. https://doi.org/10.3892/or.2010.1088
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