Association of the transforming growth factor ß1 promoter polymorphism, C-509T, with smoking status and survival in advanced non-small cell lung cancer

  • Authors:
    • Yosuke Togashi
    • Katsuhiro Masago
    • Shiro Fujita
    • Young Hak Kim
    • Yuichi Sakamori
    • Yukimasa Hatachi
    • Akiko Fukuhara
    • Hiroki Nagai
    • Tadashi Mio
    • Michiaki Mishima
  • View Affiliations

  • Published online on: December 10, 2010     https://doi.org/10.3892/or.2010.1098
  • Pages: 377-382
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Abstract

Transforming growth factor ß (TGF-ß) signaling can inhibit tumor growth in developing tumors. However, it promotes tumor invasiveness and metastasis in late-stage tumors. A number of TGF-ß gene polymorphisms have been identified that can affect the survival of patients with advanced non-small cell lung cancer (NSCLC). In this study, we investigated the association of the TGF-ß1 polymorphism, C-509T, with survival in patients with advanced NSCLC. Japanese patients who were treated for unresectable advanced NSCLC between April 2003 and March 2008 at Kyoto University Hospital, were enrolled in this study. Analyses of genotype associations with survival outcomes were performed using statistical tests. The median survival of patients with the TT genotype was shorter, although not significantly, than that of patients with either the CT or CC genotype. Based on both univariable and multivariable analyses, the TGF-ß1 polymorphism, C-509T, was not associated with prognosis. In patients with a smoking status of <40 pack-years, the median survival was significantly shorter with the TT genotype than with the CT or CC genotype. Based on univariable analysis, stage IV cancer and the TT genotype had a significant prognostic effect on survival. Based on multivariable analysis, the TT genotype was a significantly independent prognostic factor for survival. There was no association between the TGF-ß1 polymorphism, C-509T, and survival in patients with advanced NSCLC. In patients with a smoking status of <40 pack-years, however, the TGF-ß1 polymorphism, C-509T, was significantly associated with the prognosis of advanced NSCLC, and the TT genotype was an independent prognostic factor for poor survival.

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February 2011
Volume 25 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Togashi Y, Masago K, Fujita S, Kim YH, Sakamori Y, Hatachi Y, Fukuhara A, Nagai H, Mio T, Mishima M, Mishima M, et al: Association of the transforming growth factor ß1 promoter polymorphism, C-509T, with smoking status and survival in advanced non-small cell lung cancer. Oncol Rep 25: 377-382, 2011
APA
Togashi, Y., Masago, K., Fujita, S., Kim, Y.H., Sakamori, Y., Hatachi, Y. ... Mishima, M. (2011). Association of the transforming growth factor ß1 promoter polymorphism, C-509T, with smoking status and survival in advanced non-small cell lung cancer. Oncology Reports, 25, 377-382. https://doi.org/10.3892/or.2010.1098
MLA
Togashi, Y., Masago, K., Fujita, S., Kim, Y. H., Sakamori, Y., Hatachi, Y., Fukuhara, A., Nagai, H., Mio, T., Mishima, M."Association of the transforming growth factor ß1 promoter polymorphism, C-509T, with smoking status and survival in advanced non-small cell lung cancer". Oncology Reports 25.2 (2011): 377-382.
Chicago
Togashi, Y., Masago, K., Fujita, S., Kim, Y. H., Sakamori, Y., Hatachi, Y., Fukuhara, A., Nagai, H., Mio, T., Mishima, M."Association of the transforming growth factor ß1 promoter polymorphism, C-509T, with smoking status and survival in advanced non-small cell lung cancer". Oncology Reports 25, no. 2 (2011): 377-382. https://doi.org/10.3892/or.2010.1098