RC-RNase-induced cell death in estrogen receptor positive breast tumors through down-regulation of Bcl-2 and estrogen receptor

Tseng,Hsu-Hung; Yu,Yung-Luen; Chen,Yi-Lin  Sophia; Chen,Jia-Hui; Chou,Chu-Lin; Kuo,Tsun-Yung; Wang,Jaang-Jiun; Lee,Ming-Chieh; Huang,Ting-Han; Chen,Mark  Hung-Chih; Yiang,Giou-Teng

doi:10.3892/or.2010.1114

RC-RNase-induced cell death in estrogen receptor positive breast tumors through down-regulation of Bcl-2 and estrogen receptor

Authors:
- Hsu-Hung Tseng
- Yung-Luen Yu
- Yi-Lin Sophia Chen
- Jia-Hui Chen
- Chu-Lin Chou
- Tsun-Yung Kuo
- Jaang-Jiun Wang
- Ming-Chieh Lee
- Ting-Han Huang
- Mark Hung-Chih Chen
- Giou-Teng Yiang
View Affiliations

Affiliations: Division of General Surgery, Show Chwan Memorial Hospital, Changhua, Taiwan, R.O.C., Bioluminescence in Life-image Laboratory, Department of Biotechnology, Research Institute of Biotechnology, Hungkuang University, Shalu, Taichung 433, Taiwan, R.O.C., Department of Emergency Medicine, Buddhist Tzu-Chi University and General Hospital, Hualien and Taipei Branch, Taiwan, R.O.C.
Published online on: December 20, 2010 https://doi.org/10.3892/or.2010.1114
Pages: 849-853

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Abstract

RC-RNase exerts anti-cancer effects on many tumors. However, the mechanisms by which RC-RNase induces cytotoxicity in different tumor cells are unclear. Currently, estrogen receptor (ER)-positive and negative breast tumors are treated with RC-RNase. Our data demonstrate that RC-RNase induces cell death on ER-positive but not on ER-negative breast tumors. This study also shows that down-regulation of ER and Bcl-2 is found on RC-RNase-treated ER-positive breast tumors. Additionally, Bcl-2 ovexpression can prevent ER-positive breast tumors from cell death treated with RC-RNase. In summary, this study demonstrates that RC-RNase-induced cell death of ER-positive breast tumors is through regulation of ER and Bcl-2.