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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2011 Volume 25 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

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Article

CD133 is a temporary marker of cancer stem cells in small cell lung cancer, but not in non-small cell lung cancer

  • Authors:
    • Fei Cui
    • Jian Wang
    • Duan Chen
    • Yi-Jiang Chen

  • View Affiliations / Copyright

    Affiliations: Department of Thoracic and Cardiovascular Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China, The First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Avenue, Nanjing 210029, Jiangsu Province, P.R. China
  • Pages: 701-708
    |
    Published online on: December 20, 2010
       https://doi.org/10.3892/or.2010.1115
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Abstract

Lung cancer is the most common cause of cancer-related death worldwide. Current investigations in the field of cancer research have intensively focused on the ‘cancer stem cell’ or ‘tumor-initiating cell’. While CD133 was initially considered as a stem cell marker only in the hematopoietic system and the nervous system, the membrane antigen also identifies tumorigenic cells in certain solid tumors. In this study, we investigated the human lung cancer cell lines A549, H157, H226, Calu-1, H292 and H446. The results of real-time PCR analysis after chemotherapy drug selection and the fluorescence-activated cell sorting analysis showed that CD133 only functioned as a marker in the small cell lung cancer line H446. The sorted CD133+ subset presented stem cell-like features, including self-renewal, differentiation, proliferation and tumorigenic capacity in subsequent assays. Furthermore, a proportion of the CD133+ cells had a tendency to remain stable, which may explain the controversies arising from previous studies. Therefore, the CD133+ subset should provide an enriched source of tumor-initiating cells among H446 cells. Moreover, the antigen could be used as an investigative marker of the tumorigenic process and an effective treatment for small cell lung cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Cui F, Wang J, Chen D and Chen Y: CD133 is a temporary marker of cancer stem cells in small cell lung cancer, but not in non-small cell lung cancer. Oncol Rep 25: 701-708, 2011.
APA
Cui, F., Wang, J., Chen, D., & Chen, Y. (2011). CD133 is a temporary marker of cancer stem cells in small cell lung cancer, but not in non-small cell lung cancer. Oncology Reports, 25, 701-708. https://doi.org/10.3892/or.2010.1115
MLA
Cui, F., Wang, J., Chen, D., Chen, Y."CD133 is a temporary marker of cancer stem cells in small cell lung cancer, but not in non-small cell lung cancer". Oncology Reports 25.3 (2011): 701-708.
Chicago
Cui, F., Wang, J., Chen, D., Chen, Y."CD133 is a temporary marker of cancer stem cells in small cell lung cancer, but not in non-small cell lung cancer". Oncology Reports 25, no. 3 (2011): 701-708. https://doi.org/10.3892/or.2010.1115
Copy and paste a formatted citation
x
Spandidos Publications style
Cui F, Wang J, Chen D and Chen Y: CD133 is a temporary marker of cancer stem cells in small cell lung cancer, but not in non-small cell lung cancer. Oncol Rep 25: 701-708, 2011.
APA
Cui, F., Wang, J., Chen, D., & Chen, Y. (2011). CD133 is a temporary marker of cancer stem cells in small cell lung cancer, but not in non-small cell lung cancer. Oncology Reports, 25, 701-708. https://doi.org/10.3892/or.2010.1115
MLA
Cui, F., Wang, J., Chen, D., Chen, Y."CD133 is a temporary marker of cancer stem cells in small cell lung cancer, but not in non-small cell lung cancer". Oncology Reports 25.3 (2011): 701-708.
Chicago
Cui, F., Wang, J., Chen, D., Chen, Y."CD133 is a temporary marker of cancer stem cells in small cell lung cancer, but not in non-small cell lung cancer". Oncology Reports 25, no. 3 (2011): 701-708. https://doi.org/10.3892/or.2010.1115
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