Overexpression of Tiam1 predicts poor prognosis in patients with esophageal squamous cell carcinoma

  • Authors:
    • Huaimin Liu
    • Guirong Shi
    • Xiaoli Liu
    • Hui Wu
    • Qinxia Fan
    • Xin Wang
  • View Affiliations

  • Published online on: December 24, 2010     https://doi.org/10.3892/or.2010.1122
  • Pages: 841-848
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Abstract

Accumulating evidence has demonstrated that T-cell lymphoma invasion and metastasis 1 (Tiam1) plays an important role in the occurrence and development of several different tumors; however, to date, little research has been done to verify the potential role of Tiam1 as a prognostic marker for esophageal squamous cell carcinoma (ESCC). In the present study, we examined the expression of Tiam1 in ESCC tissues by immunohistochemistry, in situ hybridization, semi-quantitative RT-PCR and Western blotting methods and investigated the correlation between Tiam1 levels and prognosis of patients with ESCC. Tiam1 exhibited high expression in ESCC tissues, whereas the normal esophageal tissues showed negative or weak Tiam1 expression. Additionally, Tiam1 mRNA and protein expression levels were both significantly correlated with histology grade, clinical staging and lymph node metastasis (all P<0.05), but not related to age and gender (both P>0.05). Further, ESCC patients with strong Tiam1 mRNA (P=0.000) and protein (P=0.000) expression had a poorer prognosis than those with weak expression. These findings demonstrate that Tiam1 may be used as molecular marker for predicting the prognosis of patients with ESCC.

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March 2011
Volume 25 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Liu H, Shi G, Liu X, Wu H, Fan Q and Wang X: Overexpression of Tiam1 predicts poor prognosis in patients with esophageal squamous cell carcinoma. Oncol Rep 25: 841-848, 2011
APA
Liu, H., Shi, G., Liu, X., Wu, H., Fan, Q., & Wang, X. (2011). Overexpression of Tiam1 predicts poor prognosis in patients with esophageal squamous cell carcinoma. Oncology Reports, 25, 841-848. https://doi.org/10.3892/or.2010.1122
MLA
Liu, H., Shi, G., Liu, X., Wu, H., Fan, Q., Wang, X."Overexpression of Tiam1 predicts poor prognosis in patients with esophageal squamous cell carcinoma". Oncology Reports 25.3 (2011): 841-848.
Chicago
Liu, H., Shi, G., Liu, X., Wu, H., Fan, Q., Wang, X."Overexpression of Tiam1 predicts poor prognosis in patients with esophageal squamous cell carcinoma". Oncology Reports 25, no. 3 (2011): 841-848. https://doi.org/10.3892/or.2010.1122