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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2011 Volume 25 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

ERCC1 protein, mRNA expression and T19007C polymorphism as prognostic markers in head and neck squamous cell carcinoma patients treated with surgery and adjuvant cisplatin-based chemoradiation

  • Authors:
    • Gilberto De Castro
    • Fatima Solange Pasini
    • Sheila Aparecida Coelho Siqueira
    • Alberto Rossetti Ferraz
    • Rosangela Correa Villar
    • Igor Moysés Longo Snitcovsky
    • Miriam Hatsue Honda Federico

  • View Affiliations / Copyright

    Affiliations: Instituto do Câncer do Estado de São Paulo, Clinical Oncology, Av. Dr. Arnaldo 251, 5th floor, São Paulo, SP 01246-000, Brazil
  • Pages: 693-699
    |
    Published online on: January 3, 2011
       https://doi.org/10.3892/or.2011.1133
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Abstract

Adjuvant cisplatin-based chemoradiation improves survival in HNSCC patients presenting with risk features. ERCC1 (excision repair cross-complementation group 1) is associated with resistance to chemo- and radiation therapy and may have a prognostic value in HNSCC patients. Here we studied ERCC1 expression and the polymorphism T19007C as prognostic markers in these patients. This is a retrospective and translational analysis, where ERCC1 protein expression was evaluated by immunohistochemistry, using an H-score, and mRNA expression was determined by RT-PCR. T19007C genotypes were detected by PCR-RFLP carried out using DNA template extracted from normal lymph nodes. A high H-score was seen in 32 patients (54%), who presented better 5-year overall survival (5-y OS: 50% vs. 18%, HR 0.43, p=0.026). Fifteen out of 45 patients (33%), with high mRNA expression, presented better 5-year overall survival (OS) (86% vs. 30%, HR 0.26, p=0.052). No OS difference was detected among T19007C genotypes. High H-score and mRNA expression remained significant as favorable prognostic factors in a multivariate analysis. Collectively, our results suggest that high ERCC1 expression seems to be associated with better OS rates in HNSCC patients submitted to adjuvant cisplatin-based chemoradiation.

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Copy and paste a formatted citation
Spandidos Publications style
De Castro G, Pasini FS, Siqueira SA, Ferraz AR, Villar RC, Snitcovsky IM and Federico MH: ERCC1 protein, mRNA expression and T19007C polymorphism as prognostic markers in head and neck squamous cell carcinoma patients treated with surgery and adjuvant cisplatin-based chemoradiation. Oncol Rep 25: 693-699, 2011.
APA
De Castro , G., Pasini, F.S., Siqueira, S.A., Ferraz, A.R., Villar, R.C., Snitcovsky, I.M., & Federico, M.H. (2011). ERCC1 protein, mRNA expression and T19007C polymorphism as prognostic markers in head and neck squamous cell carcinoma patients treated with surgery and adjuvant cisplatin-based chemoradiation. Oncology Reports, 25, 693-699. https://doi.org/10.3892/or.2011.1133
MLA
De Castro , G., Pasini, F. S., Siqueira, S. A., Ferraz, A. R., Villar, R. C., Snitcovsky, I. M., Federico, M. H."ERCC1 protein, mRNA expression and T19007C polymorphism as prognostic markers in head and neck squamous cell carcinoma patients treated with surgery and adjuvant cisplatin-based chemoradiation". Oncology Reports 25.3 (2011): 693-699.
Chicago
De Castro , G., Pasini, F. S., Siqueira, S. A., Ferraz, A. R., Villar, R. C., Snitcovsky, I. M., Federico, M. H."ERCC1 protein, mRNA expression and T19007C polymorphism as prognostic markers in head and neck squamous cell carcinoma patients treated with surgery and adjuvant cisplatin-based chemoradiation". Oncology Reports 25, no. 3 (2011): 693-699. https://doi.org/10.3892/or.2011.1133
Copy and paste a formatted citation
x
Spandidos Publications style
De Castro G, Pasini FS, Siqueira SA, Ferraz AR, Villar RC, Snitcovsky IM and Federico MH: ERCC1 protein, mRNA expression and T19007C polymorphism as prognostic markers in head and neck squamous cell carcinoma patients treated with surgery and adjuvant cisplatin-based chemoradiation. Oncol Rep 25: 693-699, 2011.
APA
De Castro , G., Pasini, F.S., Siqueira, S.A., Ferraz, A.R., Villar, R.C., Snitcovsky, I.M., & Federico, M.H. (2011). ERCC1 protein, mRNA expression and T19007C polymorphism as prognostic markers in head and neck squamous cell carcinoma patients treated with surgery and adjuvant cisplatin-based chemoradiation. Oncology Reports, 25, 693-699. https://doi.org/10.3892/or.2011.1133
MLA
De Castro , G., Pasini, F. S., Siqueira, S. A., Ferraz, A. R., Villar, R. C., Snitcovsky, I. M., Federico, M. H."ERCC1 protein, mRNA expression and T19007C polymorphism as prognostic markers in head and neck squamous cell carcinoma patients treated with surgery and adjuvant cisplatin-based chemoradiation". Oncology Reports 25.3 (2011): 693-699.
Chicago
De Castro , G., Pasini, F. S., Siqueira, S. A., Ferraz, A. R., Villar, R. C., Snitcovsky, I. M., Federico, M. H."ERCC1 protein, mRNA expression and T19007C polymorphism as prognostic markers in head and neck squamous cell carcinoma patients treated with surgery and adjuvant cisplatin-based chemoradiation". Oncology Reports 25, no. 3 (2011): 693-699. https://doi.org/10.3892/or.2011.1133
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