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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2011 Volume 25 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

mTOR inhibitors show promising in vitro activity in bladder cancer and head and neck squamous cell carcinoma

  • Authors:
    • Fiona Schedel
    • Ralph Pries
    • Beate Thode
    • Brigitte Wollmann
    • Sandra Wulff
    • Dieter Jocham
    • Barbara Wollenberg
    • Ingo Kausch

  • View Affiliations / Copyright

    Affiliations: Department of Urology, University at Lübeck, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany, Department of Otorhinolaryngology, University at Lübeck, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany
  • Pages: 763-768
    |
    Published online on: January 14, 2011
       https://doi.org/10.3892/or.2011.1146
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Abstract

Bladder cancer and head and neck squamous cell carcinoma (HNSCC) are frequent but lack efficient therapies especially in advanced disease. Almost no studies on mTOR function and inhibition in these tumor entities have been reported. We examined the gene and protein expression levels of mTOR and its activated form (pmTOR) in three human bladder carcinoma cell lines (RT-4, T24, EJ28) and three HNSCC cell lines (PCI-1, PCI-13, BHY). Furthermore, the consequences of mTOR inhibition by mTOR-specific siRNAs and the mTOR inhibitor temsirolimus were analysed in vitro using immunohistochemical Ki-67 staining, mTOR and pmTOR western blot analysis, MTT assay, as well as cell cycle analysis with flow cytometry. Especially pmTOR protein expression levels showed marked differences between cell lines. siRNA transfection was associated with dose-dependent target protein reduction but not proliferation inhibition or apoptosis. On the contrary, temsirolimus significantly reduced cell viability and induced apoptosis and cell cycle arrest. According to these data, bladder cancer and HNSCC are promising tumor entities for mTOR inhibition with temsirolimus.

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Copy and paste a formatted citation
Spandidos Publications style
Schedel F, Pries R, Thode B, Wollmann B, Wulff S, Jocham D, Wollenberg B and Kausch I: mTOR inhibitors show promising in vitro activity in bladder cancer and head and neck squamous cell carcinoma . Oncol Rep 25: 763-768, 2011.
APA
Schedel, F., Pries, R., Thode, B., Wollmann, B., Wulff, S., Jocham, D. ... Kausch, I. (2011). mTOR inhibitors show promising in vitro activity in bladder cancer and head and neck squamous cell carcinoma . Oncology Reports, 25, 763-768. https://doi.org/10.3892/or.2011.1146
MLA
Schedel, F., Pries, R., Thode, B., Wollmann, B., Wulff, S., Jocham, D., Wollenberg, B., Kausch, I."mTOR inhibitors show promising in vitro activity in bladder cancer and head and neck squamous cell carcinoma ". Oncology Reports 25.3 (2011): 763-768.
Chicago
Schedel, F., Pries, R., Thode, B., Wollmann, B., Wulff, S., Jocham, D., Wollenberg, B., Kausch, I."mTOR inhibitors show promising in vitro activity in bladder cancer and head and neck squamous cell carcinoma ". Oncology Reports 25, no. 3 (2011): 763-768. https://doi.org/10.3892/or.2011.1146
Copy and paste a formatted citation
x
Spandidos Publications style
Schedel F, Pries R, Thode B, Wollmann B, Wulff S, Jocham D, Wollenberg B and Kausch I: mTOR inhibitors show promising in vitro activity in bladder cancer and head and neck squamous cell carcinoma . Oncol Rep 25: 763-768, 2011.
APA
Schedel, F., Pries, R., Thode, B., Wollmann, B., Wulff, S., Jocham, D. ... Kausch, I. (2011). mTOR inhibitors show promising in vitro activity in bladder cancer and head and neck squamous cell carcinoma . Oncology Reports, 25, 763-768. https://doi.org/10.3892/or.2011.1146
MLA
Schedel, F., Pries, R., Thode, B., Wollmann, B., Wulff, S., Jocham, D., Wollenberg, B., Kausch, I."mTOR inhibitors show promising in vitro activity in bladder cancer and head and neck squamous cell carcinoma ". Oncology Reports 25.3 (2011): 763-768.
Chicago
Schedel, F., Pries, R., Thode, B., Wollmann, B., Wulff, S., Jocham, D., Wollenberg, B., Kausch, I."mTOR inhibitors show promising in vitro activity in bladder cancer and head and neck squamous cell carcinoma ". Oncology Reports 25, no. 3 (2011): 763-768. https://doi.org/10.3892/or.2011.1146
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