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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2011 Volume 25 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Impact of MET amplification on gastric cancer: Possible roles as a novel prognostic marker and a potential therapeutic target

  • Authors:
    • Jeeyun Lee
    • Jin Won Seo
    • Hyun Jung Jun
    • Chang-Seok Ki
    • Se Hoon Park
    • Young Suk Park
    • Ho Yeong Lim
    • Min Gew Choi
    • Jae Moon Bae
    • Tae Sung Sohn
    • Jae Hyung Noh
    • Sung Kim
    • Hey-Lim Jang
    • Ji-Youn Kim
    • Kyoung-Mee Kim
    • Won Ki Kang
    • Joon Oh Park

  • View Affiliations / Copyright

    Affiliations: Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710, Republic of Korea
  • Pages: 1517-1524
    |
    Published online on: March 18, 2011
       https://doi.org/10.3892/or.2011.1219
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Abstract

Identification of critical genes which play pivotal roles in controlling tumor growth and survival will establish the basis for developing therapeutic targets. With the aim of establishing personalized medicine for treatment of solid tumors, we focused on MET amplification in gastric cancer patients, given the extreme sensitivity to c-Met inhibitor in MET amplified gastric cancer cell lines. We tested MET amplification and activation of c-Met in various gastric cancer cell lines and tissue samples from 482 gastric cancer patients who underwent curative surgery. Gastric cancer cell lines with MET amplification by quantitative real-time PCR (qPCR) and FISH predicted sensitivity to PHA-665,752, a selective c-Met kinase inhibitor. Of the 472 patients who had DNA sample available for qPCR analysis, 100 patients (21.2%) had a MET copy number greater than 4.0 copies and demonstrated poorer survival following curative surgery with statistical significance (5-year OS; 50.0 vs. 59.1%; MET amplification (+) vs. MET amplification (-); P=0.0134). These results suggest that the increased MET copy number measured by qPCR plays an important role in determining prognosis in gastric cancer patients. However, the predictive role of MET amplification for treatment response should be further explored in upcoming clinical trials.

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Copy and paste a formatted citation
Spandidos Publications style
Lee J, Seo JW, Jun HJ, Ki C, Park SH, Park YS, Lim HY, Choi MG, Bae JM, Sohn TS, Sohn TS, et al: Impact of MET amplification on gastric cancer: Possible roles as a novel prognostic marker and a potential therapeutic target. Oncol Rep 25: 1517-1524, 2011.
APA
Lee, J., Seo, J.W., Jun, H.J., Ki, C., Park, S.H., Park, Y.S. ... Park, J.O. (2011). Impact of MET amplification on gastric cancer: Possible roles as a novel prognostic marker and a potential therapeutic target. Oncology Reports, 25, 1517-1524. https://doi.org/10.3892/or.2011.1219
MLA
Lee, J., Seo, J. W., Jun, H. J., Ki, C., Park, S. H., Park, Y. S., Lim, H. Y., Choi, M. G., Bae, J. M., Sohn, T. S., Noh, J. H., Kim, S., Jang, H., Kim, J., Kim, K., Kang, W. K., Park, J. O."Impact of MET amplification on gastric cancer: Possible roles as a novel prognostic marker and a potential therapeutic target". Oncology Reports 25.6 (2011): 1517-1524.
Chicago
Lee, J., Seo, J. W., Jun, H. J., Ki, C., Park, S. H., Park, Y. S., Lim, H. Y., Choi, M. G., Bae, J. M., Sohn, T. S., Noh, J. H., Kim, S., Jang, H., Kim, J., Kim, K., Kang, W. K., Park, J. O."Impact of MET amplification on gastric cancer: Possible roles as a novel prognostic marker and a potential therapeutic target". Oncology Reports 25, no. 6 (2011): 1517-1524. https://doi.org/10.3892/or.2011.1219
Copy and paste a formatted citation
x
Spandidos Publications style
Lee J, Seo JW, Jun HJ, Ki C, Park SH, Park YS, Lim HY, Choi MG, Bae JM, Sohn TS, Sohn TS, et al: Impact of MET amplification on gastric cancer: Possible roles as a novel prognostic marker and a potential therapeutic target. Oncol Rep 25: 1517-1524, 2011.
APA
Lee, J., Seo, J.W., Jun, H.J., Ki, C., Park, S.H., Park, Y.S. ... Park, J.O. (2011). Impact of MET amplification on gastric cancer: Possible roles as a novel prognostic marker and a potential therapeutic target. Oncology Reports, 25, 1517-1524. https://doi.org/10.3892/or.2011.1219
MLA
Lee, J., Seo, J. W., Jun, H. J., Ki, C., Park, S. H., Park, Y. S., Lim, H. Y., Choi, M. G., Bae, J. M., Sohn, T. S., Noh, J. H., Kim, S., Jang, H., Kim, J., Kim, K., Kang, W. K., Park, J. O."Impact of MET amplification on gastric cancer: Possible roles as a novel prognostic marker and a potential therapeutic target". Oncology Reports 25.6 (2011): 1517-1524.
Chicago
Lee, J., Seo, J. W., Jun, H. J., Ki, C., Park, S. H., Park, Y. S., Lim, H. Y., Choi, M. G., Bae, J. M., Sohn, T. S., Noh, J. H., Kim, S., Jang, H., Kim, J., Kim, K., Kang, W. K., Park, J. O."Impact of MET amplification on gastric cancer: Possible roles as a novel prognostic marker and a potential therapeutic target". Oncology Reports 25, no. 6 (2011): 1517-1524. https://doi.org/10.3892/or.2011.1219
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