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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2011 Volume 25 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2011 Volume 25 Issue 6

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Article

Acute application of cisplatin affects methylation status in neuroblastoma cells

  • Authors:
    • Keiichi Tabata
    • Hayato Sakai
    • Ryosuke Nakajima
    • Reiko Saya-Nishimura
    • Kou Motani
    • Soichiro Okano
    • Yasuko Shibata
    • Yoshimitsu Abiko
    • Takashi Suzuki
  • View Affiliations / Copyright

    Affiliations: Research Unit of Clinical Medicine, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan
  • Pages: 1655-1660
    |
    Published online on: March 18, 2011
       https://doi.org/10.3892/or.2011.1222
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Abstract

The pharmacological mechanism of the anti-cancer effect of cisplatin is well known to be DNA intercalation, but the direct or indirect effects of cisplatin on protein expression in cancer cells remain to be explained. In this study, we used a proteomic approach to clarify the early impact of cisplatin on protein expression. In a 2-dimensional gel electrophoresis proteomic experiment, the application of cisplatin for 24 h increased the expression of four proteins and decreased the levels of one protein in neuroblastoma IMR-32 cells. Levels of S-adenosyl-L-homocysteine hydrolase, a key enzyme in methylation metabolism, were increased the most. Therefore, we examined the methylation status of histone proteins. Histone H3K9 methylation was reduced by the application of cisplatin for 24 h. These results suggest that acute cisplatin treatment alters methylation status. Thus, these data can help clarify the unknown pharmacological mechanisms of cisplatin, including the anticancer effect, adverse effects and/or the mechanism of drug resistance.

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Copy and paste a formatted citation
Spandidos Publications style
Tabata K, Sakai H, Nakajima R, Saya-Nishimura R, Motani K, Okano S, Shibata Y, Abiko Y and Suzuki T: Acute application of cisplatin affects methylation status in neuroblastoma cells. Oncol Rep 25: 1655-1660, 2011.
APA
Tabata, K., Sakai, H., Nakajima, R., Saya-Nishimura, R., Motani, K., Okano, S. ... Suzuki, T. (2011). Acute application of cisplatin affects methylation status in neuroblastoma cells. Oncology Reports, 25, 1655-1660. https://doi.org/10.3892/or.2011.1222
MLA
Tabata, K., Sakai, H., Nakajima, R., Saya-Nishimura, R., Motani, K., Okano, S., Shibata, Y., Abiko, Y., Suzuki, T."Acute application of cisplatin affects methylation status in neuroblastoma cells". Oncology Reports 25.6 (2011): 1655-1660.
Chicago
Tabata, K., Sakai, H., Nakajima, R., Saya-Nishimura, R., Motani, K., Okano, S., Shibata, Y., Abiko, Y., Suzuki, T."Acute application of cisplatin affects methylation status in neuroblastoma cells". Oncology Reports 25, no. 6 (2011): 1655-1660. https://doi.org/10.3892/or.2011.1222
Copy and paste a formatted citation
x
Spandidos Publications style
Tabata K, Sakai H, Nakajima R, Saya-Nishimura R, Motani K, Okano S, Shibata Y, Abiko Y and Suzuki T: Acute application of cisplatin affects methylation status in neuroblastoma cells. Oncol Rep 25: 1655-1660, 2011.
APA
Tabata, K., Sakai, H., Nakajima, R., Saya-Nishimura, R., Motani, K., Okano, S. ... Suzuki, T. (2011). Acute application of cisplatin affects methylation status in neuroblastoma cells. Oncology Reports, 25, 1655-1660. https://doi.org/10.3892/or.2011.1222
MLA
Tabata, K., Sakai, H., Nakajima, R., Saya-Nishimura, R., Motani, K., Okano, S., Shibata, Y., Abiko, Y., Suzuki, T."Acute application of cisplatin affects methylation status in neuroblastoma cells". Oncology Reports 25.6 (2011): 1655-1660.
Chicago
Tabata, K., Sakai, H., Nakajima, R., Saya-Nishimura, R., Motani, K., Okano, S., Shibata, Y., Abiko, Y., Suzuki, T."Acute application of cisplatin affects methylation status in neuroblastoma cells". Oncology Reports 25, no. 6 (2011): 1655-1660. https://doi.org/10.3892/or.2011.1222
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