The DPP-IV inhibitor ER-319711 has a proliferative effect on the colonic epithelium and a minimal effect in the amelioration of colitis

  • Authors:
    • Hiromitsu Ban
    • Shigeki Bamba
    • Hirotsugu Imaeda
    • Osamu Inatomi
    • Ayako Kobori
    • Masaya Sasaki
    • Tomoyuki Tsujikawa
    • Akira Andoh
    • Yoshihide Fujiyama
  • View Affiliations

  • Published online on: March 22, 2011     https://doi.org/10.3892/or.2011.1223
  • Pages: 1699-1703
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Abstract

Dipeptidyl-peptidase IV (DPP-IV) inhibitors are expected to prolong the half-life of Glucagon-like peptide (GLP-2) as well as GLP-1, and may result in the promotion of epithelial cell proliferation and regeneration. The aim of this study was to investigate whether a DPP-IV inhibitor can promote epithelial proliferation and attenuate dextran sodium sulfate (DSS)-induced colitis. Nine-week-old female C57/B6 mice were given a single dose of ER-319711 to assess the changes in plasma GLP-2 concentrations. Ten mice were divided into two groups: a vehicle group and an ER-319711 group. ER-319711 was administered orally for 7 days. The mice were then given bromodeoxyuridine (BrdU) intraperitoneally 2 h before sacrifice on day 7. Twenty-six mice were divided into three groups: a vehicle group, a DSS-induced colitis group and a DSS-induced colitis treated with ER-319711 group. The mice were given DSS for 5 days and sacrificed on day 14. Plasma GLP-2 levels were elevated in response to ER-319711. The ER-319711 group had a significantly decreased body weight from days 1 to 3. The number of BrdU positive cells per crypt and the crypt height were increased in the ER-319711 group. The DSS + ER-319711 group had a decreased body weight transition. The disease activity index and colon length showed an amelioration of colitis in the DSS + ER-319711 group. DPP-IV inhibitors are thought to promote the proliferation of the intestinal epithelium. However, the amelioration of DSS-induced colitis was only partial.

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June 2011
Volume 25 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ban H, Bamba S, Imaeda H, Inatomi O, Kobori A, Sasaki M, Tsujikawa T, Andoh A and Fujiyama Y: The DPP-IV inhibitor ER-319711 has a proliferative effect on the colonic epithelium and a minimal effect in the amelioration of colitis. Oncol Rep 25: 1699-1703, 2011
APA
Ban, H., Bamba, S., Imaeda, H., Inatomi, O., Kobori, A., Sasaki, M. ... Fujiyama, Y. (2011). The DPP-IV inhibitor ER-319711 has a proliferative effect on the colonic epithelium and a minimal effect in the amelioration of colitis. Oncology Reports, 25, 1699-1703. https://doi.org/10.3892/or.2011.1223
MLA
Ban, H., Bamba, S., Imaeda, H., Inatomi, O., Kobori, A., Sasaki, M., Tsujikawa, T., Andoh, A., Fujiyama, Y."The DPP-IV inhibitor ER-319711 has a proliferative effect on the colonic epithelium and a minimal effect in the amelioration of colitis". Oncology Reports 25.6 (2011): 1699-1703.
Chicago
Ban, H., Bamba, S., Imaeda, H., Inatomi, O., Kobori, A., Sasaki, M., Tsujikawa, T., Andoh, A., Fujiyama, Y."The DPP-IV inhibitor ER-319711 has a proliferative effect on the colonic epithelium and a minimal effect in the amelioration of colitis". Oncology Reports 25, no. 6 (2011): 1699-1703. https://doi.org/10.3892/or.2011.1223