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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2011 Volume 25 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1

  • Authors:
    • Yujie Shi
    • Shihe Yang
    • Sandi Troup
    • Xin Lu
    • Steve Callaghan
    • David S. Park
    • Ying Xing
    • Xiaohe Yang

  • View Affiliations / Copyright

    Affiliations: Department of Physiology, College of Basic Medical Science, Zhengzhou University, Zhengzhou 450001, Henan, P.R. China, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Kannapolis, NC 28081, USA
  • Pages: 1713-1719
    |
    Published online on: April 6, 2011
       https://doi.org/10.3892/or.2011.1248
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Abstract

Resveratrol is a natural polyphenolic compound with cancer chemopreventive activity. However, our understanding of the molecular mechanism responsible for resveratrol-induced apoptosis is still very limited. Here, we used MCF-7 and MDA-MB231 breast cancer cells as a model to demonstrate that resveratrol induced the expression of ASPP1, a new member of the ASPP (apoptosis stimulation protein of p53) family, which plays an important role in the regulation of apoptosis. Moreover, resveratrol enhanced apoptosis of MCF-7/ASPP1 cells, accompanied by higher expression of bax and p21. In contrast, siRNA-mediated knockdown of ASPP1 inhibited apoptosis in MB231 cells. Furthermore, we found that higher levels of ASPP1 were associated with adenovirus-mediated overexpression of E2F1 while siRNA-mediated E2F1 knockdown led to down-regulation of ASPP1. In conclusion, our results demonstrate that overexpression of ASPP1 rendered MCF-7 and MDA-MB231 breast cancer cells more sensitive to resveratrol-mediated apoptosis via the E2F pathway, thus suggesting that ASPP1 may represent a novel therapeutic target for resveratrol in human breast cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Shi Y, Yang S, Troup S, Lu X, Callaghan S, Park DS, Xing Y and Yang X: Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1. Oncol Rep 25: 1713-1719, 2011.
APA
Shi, Y., Yang, S., Troup, S., Lu, X., Callaghan, S., Park, D.S. ... Yang, X. (2011). Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1. Oncology Reports, 25, 1713-1719. https://doi.org/10.3892/or.2011.1248
MLA
Shi, Y., Yang, S., Troup, S., Lu, X., Callaghan, S., Park, D. S., Xing, Y., Yang, X."Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1". Oncology Reports 25.6 (2011): 1713-1719.
Chicago
Shi, Y., Yang, S., Troup, S., Lu, X., Callaghan, S., Park, D. S., Xing, Y., Yang, X."Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1". Oncology Reports 25, no. 6 (2011): 1713-1719. https://doi.org/10.3892/or.2011.1248
Copy and paste a formatted citation
x
Spandidos Publications style
Shi Y, Yang S, Troup S, Lu X, Callaghan S, Park DS, Xing Y and Yang X: Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1. Oncol Rep 25: 1713-1719, 2011.
APA
Shi, Y., Yang, S., Troup, S., Lu, X., Callaghan, S., Park, D.S. ... Yang, X. (2011). Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1. Oncology Reports, 25, 1713-1719. https://doi.org/10.3892/or.2011.1248
MLA
Shi, Y., Yang, S., Troup, S., Lu, X., Callaghan, S., Park, D. S., Xing, Y., Yang, X."Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1". Oncology Reports 25.6 (2011): 1713-1719.
Chicago
Shi, Y., Yang, S., Troup, S., Lu, X., Callaghan, S., Park, D. S., Xing, Y., Yang, X."Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1". Oncology Reports 25, no. 6 (2011): 1713-1719. https://doi.org/10.3892/or.2011.1248
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