Notch1 signaling pathway participates in cancer invasion by regulating MMPs in lingual squamous cell carcinoma

  • Authors:
    • Bo Yu
    • Jianhua Wei
    • Xinhong Qian
    • Delin Lei
    • Qin Ma
    • Yanpu Liu
  • View Affiliations

  • Published online on: October 6, 2011     https://doi.org/10.3892/or.2011.1492
  • Pages: 547-552
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Abstract

Some studies show the Notch signaling pathway may participate in carcinoma invasion and metastasis. However, the mechanisms by which Notch1 mediates cell invasion and migration, especially in lingual squamous cell carcinoma, are not yet known. In the current study, we demonstrated for the first time the anti-invasion and anti-metastasis effect of down-regulation of Notch1 in lingual squamous cell carcinoma. Down-regulation of Notch1 could be an effective approach for inhibition of the expression of matrix metalloproteinase (MMP)-2 and MMP-9 resulting in the inhibition of invasion and metastasis, which could be useful for devising novel preventive and therapeutic strategies for lingual squamous cell carcinoma.

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February 2012
Volume 27 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Yu B, Wei J, Qian X, Lei D, Ma Q and Liu Y: Notch1 signaling pathway participates in cancer invasion by regulating MMPs in lingual squamous cell carcinoma. Oncol Rep 27: 547-552, 2012
APA
Yu, B., Wei, J., Qian, X., Lei, D., Ma, Q., & Liu , Y. (2012). Notch1 signaling pathway participates in cancer invasion by regulating MMPs in lingual squamous cell carcinoma. Oncology Reports, 27, 547-552. https://doi.org/10.3892/or.2011.1492
MLA
Yu, B., Wei, J., Qian, X., Lei, D., Ma, Q., Liu , Y."Notch1 signaling pathway participates in cancer invasion by regulating MMPs in lingual squamous cell carcinoma". Oncology Reports 27.2 (2012): 547-552.
Chicago
Yu, B., Wei, J., Qian, X., Lei, D., Ma, Q., Liu , Y."Notch1 signaling pathway participates in cancer invasion by regulating MMPs in lingual squamous cell carcinoma". Oncology Reports 27, no. 2 (2012): 547-552. https://doi.org/10.3892/or.2011.1492