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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
February 2012 Volume 27 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Antitumor activity of chemoendocrine therapy in premenopausal and postmenopausal models with human breast cancer xenografts

Motoyuki Kataoka, Yuri Yamaguchi, Yoichiro Moriya, Noriaki Sawada, Hideyuki Yasuno, Kumiko Kondoh, Dean B. Evans, Kazushige Mori, Shin-Ichi Hayashi
Pages: 303-310
Published online on: 09 November 2011

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Article Open Access

Organellar (Na+, K+)/H+ exchanger NHE7 regulates cell adhesion, invasion and anchorage-independent growth of breast cancer MDA-MB-231 cells

Ichiro Onishi, Paulo J.C. Lin, Yuka Numata, Pamela Austin, Jane Cipollone, Michel Roberge, Calvin D. Roskelley, Masayuki Numata
Pages: 311-317
Published online on: 09 November 2011

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Article Open Access

Decreased concentrations of retinol-binding protein 4 in sera of epithelial ovarian cancer patients: A potential biomarker identified by proteomics

Lucie Lorkova, Jana Pospisilova, Jan Lacheta, Sergiu Leahomschi, Jaroslav Zivny, David Cibula, Jan Zivny, Jiri Petrak
Pages: 318-324
Published online on: 21 October 2011

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Article Open Access

Oral ingestion of Lentinula edodes mycelia extract can restore the antitumor T cell response of mice inoculated with colon-26 cells into the subserosal space of the cecum

Kousuke Tanaka, Yasunori Matsui, Satoru Ishikawa, Takashi Kawanishi, Mamoru Harada
Pages: 325-332
Published online on: 11 November 2011

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Clinical implications of 18F-fluorodeoxyglucose positron emission tomography/computed tomography at delayed phase for diagnosis and prognosis of malignant pleural mesothelioma

Yoshiyuki Abe, Katsumi Tamura, Ikuko Sakata, Jiro Ishida, Yuichi Ozeki, Atsuhisa Tamura, Kazutsugu Uematsu, Hiroshi Sakai, Tomoyuki Goya, Minoru Kanazawa, Kikuo Machida
Pages: 333-338
Published online on: 24 October 2011

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Article

shRNA against CD44 inhibits cell proliferation, invasion and migration, and promotes apoptosis of colon carcinoma cells

Yeon Sun Park, Jung Wook Huh, Jae Hyuk Lee, Hyeong Rok Kim
Pages: 339-346
Published online on: 08 November 2011

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Article

Enhancement of cytotoxic and pro-apoptotic effects of 2-aminophenoxazine-3-one on the rat hepatocellular carcinoma cell line dRLh-84, the human hepatocellular carcinoma cell line HepG2, and the rat normal hepatocellular cell line RLN-10 in combination with 2-deoxy-D-glucose

Akira Takemura, Xiao-Fang Che, Takafumi Tabuchi, Shota Moriya, Keisuke Miyazawa, Akio Tomoda
Pages: 347-355
Published online on: 08 November 2011

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Article

Inactivation of estrogen receptor by Schistosoma haematobium total antigen in bladder urothelial cells

Mónica Catarina Botelho, Ricardo Ribeiro, Nuno Vale, Paula Oliveira, Rui Medeiros, Carlos Lopes, José Carlos Machado, José Manuel Correia da Costa
Pages: 356-362
Published online on: 15 November 2011

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Efficient inhibition of an intraperitoneal xenograft model of human ovarian cancer by HSulf-1 gene delivered by biodegradable cationic heparin-polyethyleneimine nanogels

Ping Liu, Maling Gou, Tao Yi, Chuan Xie, Xiaorong Qi, Shengtao Zhou, Hongxin Deng, Yuquan Wei, Xia Zhao
Pages: 363-370
Published online on: 11 November 2011

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Article

Intestinal adenocarcinoma arising in urinary conduits

Genevieve C. Moyer, Robert L. Grubb , Frank E. Johnson
Pages: 371-375
Published online on: 08 November 2011

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Article

Novel gene hBiot2 is an independent prognostic factor in colorectal cancer patients

Yang-Mei Shen, Gunnar Arbman, Per Sandström, Per Gullstrand, Yu-Quan Wei, Hong Zhang, Johan Rosell, Birgit Olsson, Feng Peng, Han-Shuo Yang, Chun-Ting Wang, Xiao-Feng Sun
Pages: 376-382
Published online on: 24 October 2011

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Diluted povidone-iodine inhibits tumor growth through apoptosis-induction and suppression of SOD activity

Ping Sun, Ju-Mei Zhao, Zi-Chao Luo, Ping Zhang, Ping Chen, Xiao-Long Zhang, Shan Luo, Da-Bing Yang, Jiao Tan, Yi Zhou, Tao Liu, Yong-Feng Liu, Yanjun Wen
Pages: 383-388
Published online on: 08 November 2011

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Article

Expression of endothelial factors in prostate cancer: a possible role of caveolin-1 for tumour progression

Isabel Steiner, Klaus Jung, Kurt Miller, Carsten Stephan, Andreas Erbersdobler
Pages: 389-395
Published online on: 09 November 2011

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Double-stranded RNA-induced TLR3 activation inhibits angiogenesis and triggers apoptosis of human hepatocellular carcinoma cells

Zhongying Guo, Li Chen, Yuanyuan Zhu, Yixin Zhang, Song He, Jin Qin, Xiaojun Tang, Jiaming Zhou, Yingze Wei
Pages: 396-402
Published online on: 08 November 2011

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Article

PI-PLCβ1 gene copy number alterations in breast cancer

Chiara Molinari, Laura Medri, Matilde Y. Follo, Manuela Piazzi, Giulia Adalgisa Mariani, Daniele Calistri, Lucio Cocco
Pages: 403-408
Published online on: 08 November 2011

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Chondroitin sulphate enhances the antitumor activity of gemcitabine and mitomycin-C in bladder cancer cells with different mechanisms

Matteo Ferro, Gaia Giuberti, Silvia Zappavigna, Sisto Perdonà, Gaetano Facchini, Pasquale Sperlongano, Stefania Porto, Giuseppe Di Lorenzo, Carlo Buonerba, Alberto Abbruzzese, Vincenzo Altieri, Michele Caraglia
Pages: 409-415
Published online on: 31 October 2011

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Article

TWIST expression in hypopharyngeal cancer and the mechanism of TWIST-induced promotion of metastasis

Liang Yu, Sumei Lu, Jiajun Tian, Juke Ma, Jianfeng Li, Haibo Wang, Wei Xu
Pages: 416-422
Published online on: 03 October 2011

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Modulation of GemOx chemotherapy according to CIRS in elderly patients with advanced pancreatic cancer

Marianna Tudini, Eleonora Palluzzi, Katia Cannita, Maria Mancini, Alessandra Santomaggio, Gemma Bruera, Paola Lanfiuti Baldi, Michela Pelliccione, Enrico Ricevuto, Corrado Ficorella
Pages: 423-432
Published online on: 21 October 2011

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Human ether-à-go-go-related gene expression is essential for cisplatin to induce apoptosis in human gastric cancer

Riping Zhang, Pei Tian, Qiang Chi, Jizhou Wang, Yongwei Wang, Lingyu Sun, Yang Liu, Suli Tian, Qifan Zhang
Pages: 433-440
Published online on: 21 October 2011

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RNAi silencing of the MEKK3 gene promotes TRAIL-induced apoptosis in MCF-7 cells and suppresses the transcriptional activity of NF-κB

Shan-Yu Guo, Shou-Gui Liu, Lei Liu, Xiao-Jian Zhou, Yan Gu
Pages: 441-446
Published online on: 20 October 2011

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Article

Altered expression of miR-152 and miR-148a in ovarian cancer is related to cell proliferation Corrigendum in /10.3892/or.2022.8285

Xin Zhou, Fang Zhao, Zhen-Ning Wang, Yong-Xi Song, Hua Chang, Yeunpo Chiang, Hui-Mian Xu
Pages: 447-454
Published online on: 03 October 2011

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Article

The histone deacetylase inhibitor, Trichostatin A, induces G2/M phase arrest and apoptosis in YD-10B oral squamous carcinoma cells

Trinh Duc Anh, Mee-Young Ahn, Soo-A Kim, Jung-Hoon Yoon, Sang-Gun Ahn
Pages: 455-460
Published online on: 06 October 2011

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Article

Rapamycin provides a therapeutic option through inhibition of mTOR signaling in chronic myelogenous leukemia

Jie Li, Liying Xue, Hongling Hao, Yuxiang Han, Jingci Yang, Jianmin Luo
Pages: 461-466
Published online on: 12 October 2011

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Article

Toxicity profile and clinical outcomes in locally advanced head and neck cancer patients treated with induction chemotherapy prior to concurrent chemoradiation

Eric C. Ko, Eric M. Genden, Krzysztof Misiukiewicz, Peter M. Som, Lale Kostakoglu, Chien-Ting Chen, Stuart Packer, Johnny Kao
Pages: 467-474
Published online on: 21 October 2011

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Article

The improvement of liposome-mediated transfection of pEGFP DNA into human prostate cancer cells by combining low-frequency and low-energy ultrasound with microbubbles

Wen-Κun Bai, Zuo-Ηui Wu, E Shen, Ji-Ζhen Zhang, Bing Hu
Pages: 475-480
Published online on: 20 October 2011

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Article

CCL21 modulates the migration of NSCL cancer by changing the concentration of intracellular Ca2+

Jun Liu, Lei Zhang, Changli Wang
Pages: 481-486
Published online on: 08 November 2011

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Article

The spindle checkpoint protein MAD1 regulates the expression of E-cadherin and prevents cell migration

Yvan Chen, Pei-Chi Yeh, Jing-Chun Huang, Chang-Ching Yeh, Yue-Li Juang
Pages: 487-491
Published online on: 24 October 2011

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Differential expression and function of AR isoforms in prostate cancer

Rui Zeng, Zhiyong Liu, Yinghao Sun, Chuanliang Xu
Pages: 492-498
Published online on: 21 October 2011

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Article

Functional expression and characterization in Xenopus laevis oocytes of the ABCG2 transporter derived from A549 human lung adenocarcinoma cells

Dong-Goo Lee, Hee-Jung Cho, Hee Yi, Soo-Min Cho, Kyul Jo, Jin-A Park, Byung-Hwan Lee, Sung-Hee Hwang, Sang Min Jeong, Seung-Yeol Nah, Ho-Chul Shin
Pages: 499-503
Published online on: 04 October 2011

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Article

Nuclear estrogen receptor-mediated Notch signaling and GPR30-mediated PI3K/AKT signaling in the regulation of endometrial cancer cell proliferation

Yanan Wei, Zhenbo Zhang, Hong Liao, Ling Wu, Xiaomei Wu, Dongmei Zhou, Xiaowei Xi, Yaping Zhu, Youji Feng
Pages: 504-510
Published online on: 08 November 2011

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Article

SNPs/Pools: A methodology for the identification of relevant SNPs in breast cancer epidemiology

Susana N. Silva, Daniela Guerreiro, Mafalda Gomes, Ana Paula Azevedo, Guilherme Bezerra De Castro, José Rueff, Jorge F. Gaspar
Pages: 511-516
Published online on: 24 October 2011

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Article

TPA-induced p21 expression augments G2/M arrest through a p53-independent mechanism in human breast cancer cells

Jeonghun Han, Sangmin Kim, Jung-Hyun Yang, Seok Jin Nam, Jeong Eon Lee
Pages: 517-522
Published online on: 20 October 2011

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Article

Tanshinone IIA induces growth inhibition and apoptosis in gastric cancer in vitro and in vivo

Jian Chen, Dong-Yun Shi, Shan-Lin Liu, Liang Zhong
Pages: 523-528
Published online on: 27 October 2011

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Article

Role of p21 as a determinant of 1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane response in human HCT-116 colon carcinoma cells

Jane-Jen Wang, Hui-Fang Hung, Min-Li Huang, Hui-Ju Lee, Yaw-Terng Chern, Yuh-Fang Chang, Chin-Wen Chi, Yi-Chiung Hsu
Pages: 529-534
Published online on: 10 November 2011

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Article

Altered expression of phosphatase of regenerating liver gene family in non-small cell lung cancer

Jung-Joo Hwang, Sang-Hyun Min, Ki-Hyuk Sin, Young-Shin Heo, Kil-Dong Kim, Ook-Joon Yoo, Seung-Hyo Lee
Pages: 535-540
Published online on: 06 October 2011

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Article

Methanol extract of Hydroclathrus clathratus suppresses matrix metalloproteinase-9 in T24 bladder carcinoma cells by suppressing the NF-κB and MAPK pathways

R. G.P.T. Jayasooriya, Yung Hyun Choi, Sung-Kwon Moon, Wun-Jae Kim, Gi-Young Kim
Pages: 541-546
Published online on: 12 October 2011

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Article

Notch1 signaling pathway participates in cancer invasion by regulating MMPs in lingual squamous cell carcinoma

Bo Yu, Jianhua Wei, Xinhong Qian, Delin Lei, Qin Ma, Yanpu Liu
Pages: 547-552
Published online on: 06 October 2011

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Article

Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells

Yan Wu, Yongchang Chen, Rui Qu, Ting Lan, Jianrong Sang
Pages: 553-558
Published online on: 13 October 2011

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Article

Increased miR-146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis

Bin Xiao, En-Dong Zhu, Na Li, Dong-Shui Lu, Wei Li, Bo-Sheng Li, Yong-Liang Zhao, Xu-Hu Mao, Gang Guo, Pei-Wu Yu, Quan-Ming Zou
Pages: 559-566
Published online on: 21 October 2011

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Article

Genipin, a constituent of Gardenia jasminoides Ellis, induces apoptosis and inhibits invasion in MDA-MB-231 breast cancer cells

Eun-Sook Kim, Choon-Sik Jeong, Aree Moon
Pages: 567-572
Published online on: 20 October 2011

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Article

Role of hypoxia-inducible-1α in hepatocellular carcinoma cells using a Tet-on inducible system to regulate its expression in vitro

Zongquan Xu, Enyu Liu, Cheng Peng, Yunguang Li, Zhaobin He, Chuanzong Zhao, Jun Niu
Pages: 573-578
Published online on: 08 November 2011

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Article

Treatment of cancer cachexia in mice by combination of dsRNA-dependent protein kinase inhibitor and medroxyprogesterone acetate

Si-Zeng Chen, Yong-Lian Zhang
Pages: 579-584
Published online on: 09 November 2011

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Article

Angelica sinensis suppresses human lung adenocarcinoma A549 cell metastasis by regulating MMPs/TIMPs and TGF-β1

Min Gao, Jun-Hong Zhang, Fu-Xiang Zhou, Cong-Hua Xie, Guang Han, Sheng-Quan Fang, Yun-Feng Zhou
Pages: 585-593
Published online on: 04 November 2011

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Article

MiR-25 regulates apoptosis by targeting Bim in human ovarian cancer

Haiyan Zhang, Zhi Zuo, Xin Lu, Li Wang, Haiyan Wang, Zhiling Zhu
Pages: 594-598
Published online on: 08 November 2011

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Journal Cover
March-2026 Volume 55 Issue 3

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Collaborative breakthroughs in precision diagnosis and treatment of nasopharyngeal cancer: Biomarker‑driven screening and endoscopic minimally invasive surgery reshape the new paradigm of early intervention (Review)

E Jin, Wang Lin, Xiandong Zeng
Article Number: 53
Published online on: 23 January 2026

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Review Open Access

Key immune cells in the tumor immune microenvironment of colorectal cancer: Roles and research advances (Review)

Ming Qiu, Chongyuan Lan, Minglin Lin, Hui Ma
Article Number: 52
Published online on: 21 January 2026

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Correction Open Access

[Corrigendum] Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy

Xiu-Wu Pan, Lin Li, Yi Huang, Hai Huang, Dan-Feng Xu, Yi Gao, Lu Chen, Ji-Zhong Ren, Jian-Wei Cao, Yi Hong, Xin-Gang Cui
Article Number: 51
Published online on: 21 January 2026

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Review Open Access

Epigenetic mechanisms and therapeutic advances in diffuse midline glioma (Review)

Wenbo Wu, Wenlin Chen, Wenbin Ma, Yu Wang
Article Number: 50
Published online on: 20 January 2026

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Review Open Access

Recapitulating lung cancer metastasis in vitro: Advances in organoid models and challenges in clinical translation (Review)

Jian Jiang, Guomin Dong, Zhiyun Zhang, Xiaoyuan Lei, Fanshu Huang, Suoni Li, Jiequn Ma, Jie Bai, Qian Ge, Hui Wei, Zheng Zhao
Article Number: 49
Published online on: 20 January 2026

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Article Open Access

GPR176 enhances the epithelial‑mesenchymal transition in gastric cancer cells by activating the PI3K/AKT/mTOR signaling pathway

Guangchuan Mu, Kaiyan Li, Chaozhen Hu, Jintao Cai, Huichao Ruan, Guanyu Zhu, Dang Liu
Article Number: 48
Published online on: 19 January 2026

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Article Open Access

HMBOX1 inhibits hepatocellular carcinoma progression via PTPN1 mediated AKT1 phosphorylation

Chenning Zhang, Yu Jiang, Jiahui Liu, Wenyu Zhang, Jie Qi, Qing Wen, Hengli Zhao
Article Number: 47
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] Prognostic significance of miR‑218 in human hepatocellular carcinoma and its role in cell growth

Kangsheng Tu, Chao Li, Xin Zheng, Wei Yang, Yingmin Yao, Qingguang Liu
Article Number: 46
Published online on: 19 January 2026

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Review Open Access

Tumor microenvironment in bone sarcomas: Implications for immunotherapy and emerging therapeutic vulnerabilities (Review)

Wentao Li, Lijun Lv, Yibin Jin, Xin Yuan
Article Number: 45
Published online on: 16 January 2026

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Review Open Access

Immunotherapy after EGFR‑TKI treatment in advanced non‑small cell lung cancer: Current status and future perspectives (Review)

Huiyuan Ma, Longhui Li, Conghan Jiao, Yanyan Cheng, Jiayu He, Chen Jiang, Qian Tong, Dan Yi, Ying Zhang
Article Number: 44
Published online on: 16 January 2026

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Correction Open Access

[Corrigendum] Triptolide inhibits JAK2/STAT3 signaling and induces lethal autophagy through ROS generation in cisplatin‑resistant SKOV3/DDP ovarian cancer cells

Yanying Zhong, Fuyin Le, Jiao Cheng, Chen Luo, Xiali Zhang, Xingwu Wu, Fang Xu, Qi Zuo, Buzhen Tan
Article Number: 43
Published online on: 13 January 2026

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Review Open Access

Role of tumor‑infiltrating lymphocytes and miR‑155 in breast cancer: Insights into carcinogenesis and their potential as prognostic biomarkers (Review)

Miriam Monteiro Alvares‑Vilela, Franciele Schlemmer, Sabrina Simplício de Araújo Romero Ferrari, Mary-Ann Elvina Xavier, Ricardo Titze‑de‑Almeida
Article Number: 42
Published online on: 14 January 2026

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Article Open Access

CDK1 depletion suppresses glioma malignancy through cell cycle pathway regulation: Mechanistic insights from functional and molecular profiling

Yu Wang, Huandi Zhou, Xuetao Han, Dongdong Zhang, Liubing Hou, Haonan Li, Tianyi Fan, Sijie Li, Xiaoying Xue
Article Number: 41
Published online on: 12 January 2026

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Retraction Open Access

[Retracted] Downregulated microRNA‑200a promotes EMT and tumor growth through the Wnt/β‑catenin pathway by targeting the E‑cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma

Ningning Cong, Ping Du, Anling Zhang, Fajuan Shen, Juan Su, Peiyu Pu, Tao Wang, Jie Zjang, Chunsheng Kang, Qingyu Zhang
Article Number: 40
Published online on: 12 January 2026

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Review Open Access

Advances in targeting KRAS mutations: A promising approach for the treatment of non‑small cell lung cancer (Review)

Upesh Sharma, Jincheng Song, Hemraj Kandu, Yue Zhu, Zhaoxia Dai
Article Number: 39
Published online on: 08 January 2026

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Correction Open Access

[Corrigendum] CXCR6 predicts poor prognosis in gastric cancer and promotes tumor metastasis through epithelial-mesenchymal transition

Jie-Jie Jin, Fa-Xiang Dai, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Qi Hong, Qiong-Zhu Dong, Ya-Nong Wang, Hua Huang
Article Number: 38
Published online on: 05 January 2026

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April-2026 Volume 55 Issue 4

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Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

High RMI1 expression is associated with cancer cell progression and poor prognosis in prostate cancer

Pengliang Shen, Xiaosong Wang, Xiaoting Yan, Hongyang Du, Bo Wu, Xiaoming Cao
Article Number: 55
Published online on: 27 January 2026

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Retraction Open Access

[Retracted] MicroRNA‑615‑5p targets insulin‑like growth factor 2 and exerts tumor‑suppressing functions in human esophageal squamous cell carcinoma

Bingyin Yang, Rui Xie, Shang-Nong Wu, Cheng-Cheng Gao, Xiao-Zhong Yang, Jing-Fang Zhou
Article Number: 54
Published online on: 26 January 2026

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