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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2012 Volume 27 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Inactivation of estrogen receptor by Schistosoma haematobium total antigen in bladder urothelial cells

  • Authors:
    • Mónica Catarina Botelho
    • Ricardo Ribeiro
    • Nuno Vale
    • Paula Oliveira
    • Rui Medeiros
    • Carlos Lopes
    • José Carlos Machado
    • José Manuel Correia da Costa
  • View Affiliations / Copyright

    Affiliations: Centre of Parasite Immunology and Biology (CIBP), National Institute of Health, Rua Alexandre Herculano 321, 4000-055 Porto, Portugal
  • Pages: 356-362
    |
    Published online on: November 15, 2011
       https://doi.org/10.3892/or.2011.1552
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Abstract

We recently reported the expression of an estradiol-like molecule by a trematode parasite Schistosoma haematobium. We further established that this estradiol-like molecule is an antagonist of estradiol, repressing the transcriptional activity of the estrogen receptor (ER) in estrogen-responsive MCF7 cells and also that S. haematobium total antigen (Sh) contains estrogenic molecules detected by mass spectrometry. In the present study, we used HCV29 cells, a cell line derived from normal urothelial cells, as well as an in vivo model to evaluate the expression of ER in the bladders of Sh-instilled animals. We show that, similarly to MCF7 cells, Sh down-regulates the transcriptional activity of ER in HCV29 cells and also in the bladders of Sh-treated mice. The antiestrogenic activity of the S. haematobium extract and its repressive role in ER could have implications in the carcinogenic process in bladders with S. haematobium infection.

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Copy and paste a formatted citation
Spandidos Publications style
Botelho MC, Ribeiro R, Vale N, Oliveira P, Medeiros R, Lopes C, Machado JC and Correia da Costa M: Inactivation of estrogen receptor by Schistosoma haematobium total antigen in bladder urothelial cells. Oncol Rep 27: 356-362, 2012.
APA
Botelho, M.C., Ribeiro, R., Vale, N., Oliveira, P., Medeiros, R., Lopes, C. ... Correia da Costa, .M. (2012). Inactivation of estrogen receptor by Schistosoma haematobium total antigen in bladder urothelial cells. Oncology Reports, 27, 356-362. https://doi.org/10.3892/or.2011.1552
MLA
Botelho, M. C., Ribeiro, R., Vale, N., Oliveira, P., Medeiros, R., Lopes, C., Machado, J. C., Correia da Costa, . M."Inactivation of estrogen receptor by Schistosoma haematobium total antigen in bladder urothelial cells". Oncology Reports 27.2 (2012): 356-362.
Chicago
Botelho, M. C., Ribeiro, R., Vale, N., Oliveira, P., Medeiros, R., Lopes, C., Machado, J. C., Correia da Costa, . M."Inactivation of estrogen receptor by Schistosoma haematobium total antigen in bladder urothelial cells". Oncology Reports 27, no. 2 (2012): 356-362. https://doi.org/10.3892/or.2011.1552
Copy and paste a formatted citation
x
Spandidos Publications style
Botelho MC, Ribeiro R, Vale N, Oliveira P, Medeiros R, Lopes C, Machado JC and Correia da Costa M: Inactivation of estrogen receptor by Schistosoma haematobium total antigen in bladder urothelial cells. Oncol Rep 27: 356-362, 2012.
APA
Botelho, M.C., Ribeiro, R., Vale, N., Oliveira, P., Medeiros, R., Lopes, C. ... Correia da Costa, .M. (2012). Inactivation of estrogen receptor by Schistosoma haematobium total antigen in bladder urothelial cells. Oncology Reports, 27, 356-362. https://doi.org/10.3892/or.2011.1552
MLA
Botelho, M. C., Ribeiro, R., Vale, N., Oliveira, P., Medeiros, R., Lopes, C., Machado, J. C., Correia da Costa, . M."Inactivation of estrogen receptor by Schistosoma haematobium total antigen in bladder urothelial cells". Oncology Reports 27.2 (2012): 356-362.
Chicago
Botelho, M. C., Ribeiro, R., Vale, N., Oliveira, P., Medeiros, R., Lopes, C., Machado, J. C., Correia da Costa, . M."Inactivation of estrogen receptor by Schistosoma haematobium total antigen in bladder urothelial cells". Oncology Reports 27, no. 2 (2012): 356-362. https://doi.org/10.3892/or.2011.1552
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