Inactivation of estrogen receptor by Schistosoma haematobium total antigen in bladder urothelial cells

  • Authors:
    • Mónica Catarina Botelho
    • Ricardo Ribeiro
    • Nuno Vale
    • Paula Oliveira
    • Rui Medeiros
    • Carlos Lopes
    • José Carlos Machado
    • José Manuel Correia da Costa
  • View Affiliations

  • Published online on: November 15, 2011     https://doi.org/10.3892/or.2011.1552
  • Pages: 356-362
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Abstract

We recently reported the expression of an estradiol-like molecule by a trematode parasite Schistosoma haematobium. We further established that this estradiol-like molecule is an antagonist of estradiol, repressing the transcriptional activity of the estrogen receptor (ER) in estrogen-responsive MCF7 cells and also that S. haematobium total antigen (Sh) contains estrogenic molecules detected by mass spectrometry. In the present study, we used HCV29 cells, a cell line derived from normal urothelial cells, as well as an in vivo model to evaluate the expression of ER in the bladders of Sh-instilled animals. We show that, similarly to MCF7 cells, Sh down-regulates the transcriptional activity of ER in HCV29 cells and also in the bladders of Sh-treated mice. The antiestrogenic activity of the S. haematobium extract and its repressive role in ER could have implications in the carcinogenic process in bladders with S. haematobium infection.

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February 2012
Volume 27 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Botelho MC, Ribeiro R, Vale N, Oliveira P, Medeiros R, Lopes C, Machado JC and Correia da Costa M: Inactivation of estrogen receptor by Schistosoma haematobium total antigen in bladder urothelial cells. Oncol Rep 27: 356-362, 2012
APA
Botelho, M.C., Ribeiro, R., Vale, N., Oliveira, P., Medeiros, R., Lopes, C. ... Correia da Costa, .M. (2012). Inactivation of estrogen receptor by Schistosoma haematobium total antigen in bladder urothelial cells. Oncology Reports, 27, 356-362. https://doi.org/10.3892/or.2011.1552
MLA
Botelho, M. C., Ribeiro, R., Vale, N., Oliveira, P., Medeiros, R., Lopes, C., Machado, J. C., Correia da Costa, . M."Inactivation of estrogen receptor by Schistosoma haematobium total antigen in bladder urothelial cells". Oncology Reports 27.2 (2012): 356-362.
Chicago
Botelho, M. C., Ribeiro, R., Vale, N., Oliveira, P., Medeiros, R., Lopes, C., Machado, J. C., Correia da Costa, . M."Inactivation of estrogen receptor by Schistosoma haematobium total antigen in bladder urothelial cells". Oncology Reports 27, no. 2 (2012): 356-362. https://doi.org/10.3892/or.2011.1552