miR-24 functions as a tumor suppressor in Hep2 laryngeal carcinoma cells partly through down-regulation of the S100A8 protein

  • Authors:
    • Yan Guo
    • Weineng Fu
    • Hong Chen
    • Chao Shang
    • Ming Zhong
  • View Affiliations

  • Published online on: November 30, 2011     https://doi.org/10.3892/or.2011.1571
  • Pages: 1097-1103
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

microRNAs, a family of small non-coding RNAs, regulating approximately 30% of all human genes are deeply involved in the pathogenesis of several types of cancers, including laryngeal squamous cell carcinoma (LSCC). Here, we demonstrate that miR-24 is down-regulated in human LSCC tissues. Ectopic expression of miR-24 in Hep2 cells significantly induced cell morphology changes and inhibited cell proliferation and invasion ability in vitro by targeting S100A8 at the translational level. Meanwhile, miR-24 could significantly inhibit Hep2 cell invasion after S100A8 protein blockade. In conclusion, our results suggest that miR-24 may function as a tumor suppressor in LSCC through down-regulation of S100A8, which suggests that miR-24 could serve as a novel potential maker for LSCC therapy.
View Figures
View References

Related Articles

Journal Cover

April 2012
Volume 27 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Guo Y, Fu W, Chen H, Shang C and Zhong M: miR-24 functions as a tumor suppressor in Hep2 laryngeal carcinoma cells partly through down-regulation of the S100A8 protein. Oncol Rep 27: 1097-1103, 2012
APA
Guo, Y., Fu, W., Chen, H., Shang, C., & Zhong, M. (2012). miR-24 functions as a tumor suppressor in Hep2 laryngeal carcinoma cells partly through down-regulation of the S100A8 protein. Oncology Reports, 27, 1097-1103. https://doi.org/10.3892/or.2011.1571
MLA
Guo, Y., Fu, W., Chen, H., Shang, C., Zhong, M."miR-24 functions as a tumor suppressor in Hep2 laryngeal carcinoma cells partly through down-regulation of the S100A8 protein". Oncology Reports 27.4 (2012): 1097-1103.
Chicago
Guo, Y., Fu, W., Chen, H., Shang, C., Zhong, M."miR-24 functions as a tumor suppressor in Hep2 laryngeal carcinoma cells partly through down-regulation of the S100A8 protein". Oncology Reports 27, no. 4 (2012): 1097-1103. https://doi.org/10.3892/or.2011.1571