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Article

Autophagy induced by baicalin involves downregulation of CD147 in SMMC-7721 cells in vitro

  • Authors:
    • Xianjiao Zhang
    • Xu Tang
    • Hanqiang Liu
    • Lianxiang Li
    • Qian Hou
    • Jianmin Gao
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Xi'an Jiaotong University, 86 Box, 76 West Yanta Street, Xi'an 710061, P.R. China
  • Pages: 1128-1134
    |
    Published online on: December 20, 2011
       https://doi.org/10.3892/or.2011.1599
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Abstract

Baicalin has been demonstrated to exert anticancer effects mainly through induction of tumor cell apoptosis and cell cycle arrest. However, the precise mechanisms underlying its anticancer role remain to be elucidated. In the present study, we investigated whether autophagy was involved in the anticancer activity of baicalin in the human hepatocellular carcinoma (HCC) cell line SMMC-7721 and the possible molecular mechanisms. Our data showed that the viability of SMMC-7721 cells was significantly inhibited by baicalin in a dose- and time-dependent manner. Alongside apoptosis, autophagy was also induced by baicalin dose- and time-dependently with the involvement of the autophagy-associated protein Βeclin 1. Moreover, we demonstrated that cell death induced by baicalin was significantly inhibited by the apoptosis inhibitor z-DEVD-fmk or the autophagy inhibitor 3-MA, respectively. In addition, we found that CD147, a key molecule related both to apoptosis and autophagy, was markedly downregulated at the protein level in SMMC-7721 cells treated with baicalin. Collectively, this is the first study to suggest that baicalin induces autophagic cell death in SMMC-7721 cells, which involves the downregulation of CD147. Our study reveals a new mechanism for the anticancer effects of baicalin and puts forward a potential crucial role of CD147 in baicalin-induced cancer cell death.
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View References

1 

Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar

2 

Kassahun WT, Fangmann J, Harms J, Hauss J and Bartels M: Liver resection and transplantation in the management of hepatocellular carcinoma: a review. Exp Clin Transplant. 4:549–558. 2006.PubMed/NCBI

3 

Wang N, Tang LJ, Zhu GQ, et al: Apoptosis induced by baicalin involving up-regulation of P53 and bax in MCF-7 cells. J Asian Nat Prod Res. 10:1129–1135. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Li-Weber M: New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat Rev. 35:57–68. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Ikemoto S, Sugimura K, Yoshida N, et al: Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines. Urology. 55:951–955. 2000.

6 

Goh D, Lee YH and Ong ES: Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo. J Agric Food Chem. 53:8197–8204. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Guo Y and Yao S: Effect of baicalin on invasion and metastasis of human hepatocellular line BEL-7402 in vitro. Acta Academiae Medicinae Militaris Tertiae. 6:332006.

8 

Mathew R, Karantza-Wadsworth V and White E: Role of autophagy in cancer. Nat Rev Cancer. 7:961–967. 2007. View Article : Google Scholar

9 

Klionsky DJ and Emr SD: Autophagy as a regulated pathway of cellular degradation. Science. 290:1717–1721. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Cao Y and Klionsky DJ: Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell Res. 17:839–849. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Krustev LP: Cell autophagy of the liver in starvation and undernutrition. Bibl Nutr Dieta. 23:145–154. 1976.PubMed/NCBI

12 

Qu X, Zou Z, Sun Q, et al: Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell. 128:931–946. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Takagi H, Matsui Y and Sadoshima J: The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart. Antioxid Redox Signal. 9:1373–1382. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Gozuacik D and Kimchi A: Autophagy as a cell death and tumor suppressor mechanism. Oncogene. 23:2891–2906. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Dalby KN, Tekedereli I, Lopez-Berestein G and Ozpolat B: Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy. 6:322–329. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Wang N, Feng Y, Zhu M, et al: Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism. J Cell Biochem. 111:1426–1436. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Hou Q, Tang X, Liu H, et al: Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147. Cancer Sci. 102:1287–1292. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y and Kondo S: Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene. 24:980–991. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Xu J, Xu HY, Zhang Q, et al: HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma. Mol Cancer Res. 5:605–614. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Zhang Q, Zhou J, Ku XM, et al: Expression of CD147 as a significantly unfavorable prognostic factor in hepatocellular carcinoma. Eur J Cancer Prev. 16:196–202. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Kuang YH, Chen X, Su J, et al: RNA interference targeting the CD147 induces apoptosis of multi-drug resistant cancer cells related to XIAP depletion. Cancer Lett. 276:189–195. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Yang JM, O’Neill P, Jin W, et al: Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. J Biol Chem. 281:9719–9727. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Dai J, Dou K, Wang C, et al: The interaction of HAb18G/CD147 with integrin α6β1 and its implications for the invasion potential of human hepatoma cells. BMC Cancer. 9:3372009.

24 

Tang J, Wu YM, Zhao P, Yang XM, Jiang JL and Chen ZN: Overexpression of HAb18G/CD147 promotes invasion and metastasis via α3β1 integrin mediated FAK-paxillin and FAK-PI3K-Ca 2+ pathways. Cell Mol Life Sci. 65:2933–2942. 2008.PubMed/NCBI

25 

Chen Y, Zhang H, Gou X, Horikawa Y, Xing J and Chen Z: Upregulation of HAb18G/CD147 in activated human umbilical vein endothelial cells enhances the angiogenesis. Cancer Lett. 278:113–121. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Gou X, Ru Q, Zhang H, et al: HAb18G/CD147 inhibits starvation-induced autophagy in human hepatoma cell SMMC7721 with an involvement of Beclin 1 down-regulation. Cancer Sci. 100:837–843. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Yuan SL, Wei YQ, Wang XJ, Xiao F, Li SF and Zhang J: Growth inhibition and apoptosis induction of tanshinone II-A on human hepatocellular carcinoma cells. World J Gastroenterol. 10:2024–2028. 2004.PubMed/NCBI

28 

Kabeya Y, Mizushima N, Ueno T, et al: LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19:5720–5728. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Qu X, Yu J, Bhagat G, et al: Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 112:1809–1820. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Liang XH, Yu J, Brown K and Levine B: Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. Cancer Res. 61:3443–3449. 2001.PubMed/NCBI

31 

Strober W: Trypan blue exclusion test of cell viability. Curr Protoc Immunol Appendix 3: Appendix 3B. 2001. View Article : Google Scholar

32 

Balgi AD, Fonseca BD, Donohue E, et al: Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One. 4:e71242009. View Article : Google Scholar : PubMed/NCBI

33 

Ikezoe T, Chen SS, Heber D, Taguchi H and Koeffler HP: Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest. Prostate. 49:285–292. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Chan FL, Choi HL, Chen ZY, Chan PSF and Huang Y: Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. Cancer Lett. 160:219–228. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Mizushima N, Yoshimori T and Levine B: Methods in mammalian autophagy research. Cell. 140:313–326. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Knoblach SM, Alroy DA, Nikolaeva M, Cernak I, Stoica BA and Faden AI: Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury. J Cereb Blood Flow Metab. 24:1119–1132. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Pattingre S, Tassa A, Qu X, et al: Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 122:927–939. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Yousefi S, Perozzo R, Schmid I, et al: Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol. 8:1124–1132. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Kondo Y, Kanzawa T, Sawaya R and Kondo S: Role of autophagy in cancer development and response to therapy. Nat Rev Cancer. 5:726–734. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Gonzalez-Angulo AM, Walters RS, Carpenter JRJ, et al: Paclitaxel chemotherapy in a pregnant patient with bilateral breast cancer. Clin Breast Cancer. 5:317–319. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Romero A, Rabinovich MG, Vallejo CT, et al: Vinorelbine as first-line chemotherapy for metastatic breast carcinoma. J Clin Oncol. 12:336–341. 1994.PubMed/NCBI

42 

Holland JF, Scharlau C, Gailani S, et al: Vincristine treatment of advanced cancer: a cooperative study of 392 cases. Cancer Res. 33:1258–1264. 1973.PubMed/NCBI

43 

Newman DJ and Cragg GM: Natural products as sources of new drugs over the last 25 years. J Nat Prod. 70:461–477. 2007.PubMed/NCBI

44 

Franek KJ, Zengtong Z, Zhang WD and Chen WY: In vitro studies of baicalin alone or in combination with Salvia miltiorrhiza extract as a potential anti-cancer agent. Int J Oncol. 26:217–224. 2005.

45 

Xu XF, Cai BL, Guan SM, et al: Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo. Invest New Drugs. 29:637–645. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Levine B and Kroemer G: Autophagy in the pathogenesis of disease. Cell. 132:27–42. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Liang XH, Jackson S, Seaman M, et al: Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature. 402:672–675. 1999. View Article : Google Scholar : PubMed/NCBI

48 

Li DD, Wang LL, Deng R, et al: The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells. Oncogene. 28:886–898. 2008.

49 

Takahashi Y, Coppola D, Matsushita N, et al: Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol. 9:1142–1151. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Pattingre S and Levine B: Bcl-2 inhibition of autophagy: a new route to cancer? Cancer Res. 66:2885–2828. 2006. View Article : Google Scholar : PubMed/NCBI

51 

Sun PH, Zhu LM, Qiao MM, et al: The XAF1 tumor suppressor induces autophagic cell death via upregulation of Beclin-1 and inhibition of Akt pathway. Cancer Lett. 28:170–180. 2011.PubMed/NCBI

52 

Tang Y, Nakada MT, Kesavan P, et al: Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases. Cancer Res. 65:3193–3199. 2005.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Tang X, Liu H, Li L, Hou Q and Gao J: Autophagy induced by baicalin involves downregulation of CD147 in SMMC-7721 cells in vitro. Oncol Rep 27: 1128-1134, 2012.
APA
Zhang, X., Tang, X., Liu, H., Li, L., Hou, Q., & Gao, J. (2012). Autophagy induced by baicalin involves downregulation of CD147 in SMMC-7721 cells in vitro. Oncology Reports, 27, 1128-1134. https://doi.org/10.3892/or.2011.1599
MLA
Zhang, X., Tang, X., Liu, H., Li, L., Hou, Q., Gao, J."Autophagy induced by baicalin involves downregulation of CD147 in SMMC-7721 cells in vitro". Oncology Reports 27.4 (2012): 1128-1134.
Chicago
Zhang, X., Tang, X., Liu, H., Li, L., Hou, Q., Gao, J."Autophagy induced by baicalin involves downregulation of CD147 in SMMC-7721 cells in vitro". Oncology Reports 27, no. 4 (2012): 1128-1134. https://doi.org/10.3892/or.2011.1599
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Tang X, Liu H, Li L, Hou Q and Gao J: Autophagy induced by baicalin involves downregulation of CD147 in SMMC-7721 cells in vitro. Oncol Rep 27: 1128-1134, 2012.
APA
Zhang, X., Tang, X., Liu, H., Li, L., Hou, Q., & Gao, J. (2012). Autophagy induced by baicalin involves downregulation of CD147 in SMMC-7721 cells in vitro. Oncology Reports, 27, 1128-1134. https://doi.org/10.3892/or.2011.1599
MLA
Zhang, X., Tang, X., Liu, H., Li, L., Hou, Q., Gao, J."Autophagy induced by baicalin involves downregulation of CD147 in SMMC-7721 cells in vitro". Oncology Reports 27.4 (2012): 1128-1134.
Chicago
Zhang, X., Tang, X., Liu, H., Li, L., Hou, Q., Gao, J."Autophagy induced by baicalin involves downregulation of CD147 in SMMC-7721 cells in vitro". Oncology Reports 27, no. 4 (2012): 1128-1134. https://doi.org/10.3892/or.2011.1599
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