Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas

  • Authors:
    • Ping Zhan
    • Xiao-Kun Shen
    • Qian Qian
    • Qin Wang
    • Ji-Ping Zhu
    • Yu Zhang
    • Hai-Yan Xie
    • Chuen-Hua Xu
    • Ke-Ke Hao
    • Wei Hu
    • Ning Xia
    • Guo-Jun Lu
    • Li-Ke Yu
  • View Affiliations

  • Published online on: December 21, 2011     https://doi.org/10.3892/or.2011.1605
  • Pages: 1072-1078
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Caveolin-1 (cav-1) has been implicated in the development of human cancers. However, the distribution of cav-1 in non-small cell lung cancer (NSCLC) and its significance require further study. Real-time PCR and Western blot assays were performed to detect cav-1 mRNA and protein levels in tumor tissues (TT) and matched tumor-free tissues (TF). The protein expression in 115 paraffin-embedded blocks was examined by immunohistochemical staining (IHC). Correlations between cav-1 mRNA and protein expression by IHC and clinicopathological features were statistically evaluated. For the 136 patients examined, the levels of cav-1 mRNA and protein expression were significantly lower in lung TT compared to matched TF (P<0.05). High cav-1 expression was detected in 60 of 115 (52.2%) NSCLC tissues and this level was significantly lower than cav-1 expression in non-cancerous lung tissues (15 of 19, 78.9%, P<0.05). Up-regulation of cav-1 mRNA expression in lung adenocarcinoma (AC) (29.7%) was higher than that observed in lung squamous cell carcinoma (SCC) (15.8%). Statistical analysis of the correlation between cav-1 protein expression and clinical features showed a statistical association with poorer N-stage (P=0.032) and higher pathological TNM stage (P=0.012) in lung AC patients, that was not found in lung SCC patients. Moreover, lung AC patients with higher cav-1 expression showed significantly shorter life-spans than those with lower cav-1 expression (P=0.032, log-rank test). The levels of cav-1 mRNA and protein expression were significantly lower in lung cancers when compared to matched TF or non-cancerous lung tissues. The higher protein expression correlated with the advanced pathological stage and shorter survival rates in lung AC patients.
View Figures
View References

Related Articles

Journal Cover

April 2012
Volume 27 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhan P, Shen X, Qian Q, Wang Q, Zhu J, Zhang Y, Xie H, Xu C, Hao K, Hu W, Hu W, et al: Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas. Oncol Rep 27: 1072-1078, 2012
APA
Zhan, P., Shen, X., Qian, Q., Wang, Q., Zhu, J., Zhang, Y. ... Yu, L. (2012). Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas. Oncology Reports, 27, 1072-1078. https://doi.org/10.3892/or.2011.1605
MLA
Zhan, P., Shen, X., Qian, Q., Wang, Q., Zhu, J., Zhang, Y., Xie, H., Xu, C., Hao, K., Hu, W., Xia, N., Lu, G., Yu, L."Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas". Oncology Reports 27.4 (2012): 1072-1078.
Chicago
Zhan, P., Shen, X., Qian, Q., Wang, Q., Zhu, J., Zhang, Y., Xie, H., Xu, C., Hao, K., Hu, W., Xia, N., Lu, G., Yu, L."Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas". Oncology Reports 27, no. 4 (2012): 1072-1078. https://doi.org/10.3892/or.2011.1605