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Article

Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas

  • Authors:
    • Ping Zhan
    • Xiao-Kun Shen
    • Qian Qian
    • Qin Wang
    • Ji-Ping Zhu
    • Yu Zhang
    • Hai-Yan Xie
    • Chuen-Hua Xu
    • Ke-Ke Hao
    • Wei Hu
    • Ning Xia
    • Guo-Jun Lu
    • Li-Ke Yu
  • View Affiliations / Copyright

    Affiliations: First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing 210029, P.R. China, First Department of Respiratory Medicine, Nanjing Chest Hospital, 215 Guangzhou Road, Nanjing 210029, P.R. China
  • Pages: 1072-1078
    |
    Published online on: December 21, 2011
       https://doi.org/10.3892/or.2011.1605
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Abstract

Caveolin-1 (cav-1) has been implicated in the development of human cancers. However, the distribution of cav-1 in non-small cell lung cancer (NSCLC) and its significance require further study. Real-time PCR and Western blot assays were performed to detect cav-1 mRNA and protein levels in tumor tissues (TT) and matched tumor-free tissues (TF). The protein expression in 115 paraffin-embedded blocks was examined by immunohistochemical staining (IHC). Correlations between cav-1 mRNA and protein expression by IHC and clinicopathological features were statistically evaluated. For the 136 patients examined, the levels of cav-1 mRNA and protein expression were significantly lower in lung TT compared to matched TF (P<0.05). High cav-1 expression was detected in 60 of 115 (52.2%) NSCLC tissues and this level was significantly lower than cav-1 expression in non-cancerous lung tissues (15 of 19, 78.9%, P<0.05). Up-regulation of cav-1 mRNA expression in lung adenocarcinoma (AC) (29.7%) was higher than that observed in lung squamous cell carcinoma (SCC) (15.8%). Statistical analysis of the correlation between cav-1 protein expression and clinical features showed a statistical association with poorer N-stage (P=0.032) and higher pathological TNM stage (P=0.012) in lung AC patients, that was not found in lung SCC patients. Moreover, lung AC patients with higher cav-1 expression showed significantly shorter life-spans than those with lower cav-1 expression (P=0.032, log-rank test). The levels of cav-1 mRNA and protein expression were significantly lower in lung cancers when compared to matched TF or non-cancerous lung tissues. The higher protein expression correlated with the advanced pathological stage and shorter survival rates in lung AC patients.
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1 

Alberg AJ and Samet JM: Epidemiology of lung cancer. Chest. 123:21–49. 2003. View Article : Google Scholar

2 

Molina JR, Yang P, Cassivi SD, Schild SE and Adjei AA: Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 83:584–594. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Alberg AJ, Ford JG and Samet JM: Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines. Chest. 132:29S–55S. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Paesmans M, Sculier JP, Libert P, et al: Prognostic factors for survival in advanced non-small-cell lung cancer: univariate and multivariate analyses including recursive partitioning and amalgamation algorithms in 1,052 patients. The European Lung Cancer Working Party. J Clin Oncol. 13:1221–1230. 1995.

5 

Rothberg KG, Heuser JE, Donzell WC, et al: Caveolin, a protein component of caveolae membrane coats. Cell. 68:673–682. 1992. View Article : Google Scholar : PubMed/NCBI

6 

Sloan EK, Stanley KL and Anderson RL: Caveolin-1 inhibits breast cancer growth and metastasis. Oncogene. 23:7893–7897. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Williams TM, Medina F, Badano I, et al: Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo: role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. J Biol Chem. 279:51630–51646. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Razani B, Altschuler Y, Zhu L, et al: Caveolin-1 expression is down-regulated in cells transformed by the human papilloma virus in a p53-dependent manner. Replacement of caveolin-1 expression suppresses HPV-mediated cell transformation. Biochemistry. 39:13916–13924. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Racine C, Belanger M, Hirabayashi H, et al: Reduction of caveolin 1 gene expression in lung carcinoma cell lines. Biochem Biophys Res Commun. 255:580–586. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Sunaga N, Miyajima K, Suzuki M, et al: Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer. Cancer Res. 64:4277–4285. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Wiechen K, Diatchenko L, Agoulnik A, et al: Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene. Am J Pathol. 159:1635–1643. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Galbiati F, Volonte D, Engelman JA, et al: Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. EMBO J. 17:6633–6648. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Koleske AJ, Baltimore D and Lisanti MP: Reduction of caveolin and caveolae in oncogenically transformed cells. Proc Natl Acad Sci USA. 92:1381–1385. 1995. View Article : Google Scholar : PubMed/NCBI

14 

Fong A, Garcia E, Gwynn L, et al: Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation. Am J Clin Pathol. 120:93–100. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Hu YC, Lam KY, Law S, et al: Profiling of differentially expressed cancer-related genes in esophageal squamous cell carcinoma (ESCC) using human cancer cDNA arrays: overexpression of oncogene MET correlates with tumor differentiation in ESCC. Clin Cancer Res. 7:3519–3525. 2001.

16 

Li L, Yang G, Ebara S, et al: Caveolin-1 mediates testosterone stimulate survival/clonal growth and promotes metastatic activities in prostate cancer cells. Cancer Res. 61:4386–4392. 2001.PubMed/NCBI

17 

Kato K, Hida Y, Miyamoto M, et al: Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage. Cancer. 94:929–933. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Yang G, Truong LD, Wheeler TM, et al: Caveolin-1 expression in clinically confined human prostate cancer: a novel prognostic marker. Cancer Res. 59:5719–5723. 1999.PubMed/NCBI

19 

Ho CC, Huang PH, Huang HY, et al: Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation. Am J Pathol. 161:1647–1656. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Yoo SH, Park YS, Kim HR, et al: Expression of caveolin-1 is associated with poor prognosis of patients with squamous cell carcinoma of the lung. Lung Cancer. 42:195–202. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Moon KC, Lee GK, Yoo SH, et al: Expression of caveolin-1 in pleomorphic carcinoma of the lung is correlated with a poor prognosis. Anticancer Res. 25:4631–4637. 2005.PubMed/NCBI

22 

Kato T, Miyamoto M, Kato K, et al: Difference of caveolin-1 expression pattern in human lung neoplastic tissue. Atypical adenomatous hyperplasia, adenocarcinoma and squamous cell carcinoma. Cancer Lett. 214:121–128. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Wikman H, Seppänen JK, Sarhadi VK, et al: Caveolins as tumour markers in lung cancer detected by combined use of cDNA and tissue microarrays. J Pathol. 203:584–593. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Ho CC, Kuo SH, Huang PH, et al: Caveolin-1 expression is significantly associated with drug resistance and poor prognosis in advanced non-small cell lung cancer patients treated with gemcitabine-based chemotherapy. Lung Cancer. 59:105–110. 2008. View Article : Google Scholar

25 

Groome PA, Bolejack V, Crowley JJ, et al; IASLC International Staging Committee; Cancer Research and Biostatistics; Observers to the Committee; Participating Institutions. The IASLC Lung Cancer Staging Project: validation of the proposals for revision of the T, N and M descriptors and consequent stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol. 2:694–705. 2007. View Article : Google Scholar

26 

Li S, Couet J and Lisanti MP: Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin: caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J Biol Chem. 271:29182–29190. 1996. View Article : Google Scholar

27 

Oka N, Yamamoto M, Schwencke C, et al: Caveolin interaction with protein kinase C: isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide. J Biol Chem. 272:33416–33421. 1997. View Article : Google Scholar : PubMed/NCBI

28 

Couet J, Sargiacomo M and Lisanti MP: Interaction of a receptor tyrosine kinase, EGF-R, with caveolins: caveolin binding negatively regulates tyrosine and serine/threonine kinase activities. J Biol Chem. 272:30429–30438. 1997. View Article : Google Scholar

29 

Razani B, Zhang XL, Bitzer M, et al: Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor. J Biol Chem. 276:6727–6738. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Galbiati F, Volonte D, Brown AM, et al: Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains. J Biol Chem. 275:23368–23377. 2000. View Article : Google Scholar : PubMed/NCBI

31 

Campbell L, Hollins AJ, Al-Eid A, et al: Caveolin-1 expression and caveolae biogenesis during cell transdifferentiation in lung alveolar epithelial primary cultures. Biochem Biophys Res Commun. 262:744–751. 1999. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhan P, Shen X, Qian Q, Wang Q, Zhu J, Zhang Y, Xie H, Xu C, Hao K, Hu W, Hu W, et al: Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas. Oncol Rep 27: 1072-1078, 2012.
APA
Zhan, P., Shen, X., Qian, Q., Wang, Q., Zhu, J., Zhang, Y. ... Yu, L. (2012). Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas. Oncology Reports, 27, 1072-1078. https://doi.org/10.3892/or.2011.1605
MLA
Zhan, P., Shen, X., Qian, Q., Wang, Q., Zhu, J., Zhang, Y., Xie, H., Xu, C., Hao, K., Hu, W., Xia, N., Lu, G., Yu, L."Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas". Oncology Reports 27.4 (2012): 1072-1078.
Chicago
Zhan, P., Shen, X., Qian, Q., Wang, Q., Zhu, J., Zhang, Y., Xie, H., Xu, C., Hao, K., Hu, W., Xia, N., Lu, G., Yu, L."Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas". Oncology Reports 27, no. 4 (2012): 1072-1078. https://doi.org/10.3892/or.2011.1605
Copy and paste a formatted citation
x
Spandidos Publications style
Zhan P, Shen X, Qian Q, Wang Q, Zhu J, Zhang Y, Xie H, Xu C, Hao K, Hu W, Hu W, et al: Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas. Oncol Rep 27: 1072-1078, 2012.
APA
Zhan, P., Shen, X., Qian, Q., Wang, Q., Zhu, J., Zhang, Y. ... Yu, L. (2012). Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas. Oncology Reports, 27, 1072-1078. https://doi.org/10.3892/or.2011.1605
MLA
Zhan, P., Shen, X., Qian, Q., Wang, Q., Zhu, J., Zhang, Y., Xie, H., Xu, C., Hao, K., Hu, W., Xia, N., Lu, G., Yu, L."Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas". Oncology Reports 27.4 (2012): 1072-1078.
Chicago
Zhan, P., Shen, X., Qian, Q., Wang, Q., Zhu, J., Zhang, Y., Xie, H., Xu, C., Hao, K., Hu, W., Xia, N., Lu, G., Yu, L."Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas". Oncology Reports 27, no. 4 (2012): 1072-1078. https://doi.org/10.3892/or.2011.1605
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