Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
April 2012 Volume 27 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April 2012 Volume 27 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Upregulation of β2-microglobulin expression in progressive human oral squamous cell carcinoma

  • Authors:
    • Qian Jiang
    • Sdek Patima
    • Dong-Xia Ye
    • Hong-Ya Pan
    • Pin Zhang
    • Zhi-Yuan Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Research Institute of Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai, P.R. China, Division of Cardiology, University of California at Los Angeles, The Cardiovascular Research Laboratory, Department of Medicine, David Geffen School of Medicine, Los Angeles, CA, USA
  • Pages: 1058-1064
    |
    Published online on: December 30, 2011
       https://doi.org/10.3892/or.2011.1613
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate β2-microglobulin (β2-M) expression in normal oral mucosa and progressive oral squamous cell carcinoma (OSCC) and to assess the clinical significance of β2-microglobulin expression. The study included 10 cases of normal oral mucosa epithelium specimens, 55 cases of primary OSCC specimens, and 25 cases of OSCC metastasis specimens. Immunohistochemistry was used to determine β2-M expression, and its correlation with clinicopathological factors in progressive OSCC was evaluated. Immunohistochemistry showed that strong β2-M expression was significantly asscociated with tumor size (T3, T4 vs. T1, T2; P=0.001), positive node status (N positive vs. N negative; P=0.000) and advanced clinical stage (Ⅲ, Ⅳ vs. Ⅰ, Ⅱ, P=0.000) in primary OSCC lesions. Compared to primary OSCC lesions, the frequency of β2-M expression was significantly increased in metastatic OSCC lesions (P=0.02). In addition, in vitro results from Western blotting showed increased β2-M expression in the two OSCC lines studied. Therefore, we speculate that the up-regulation of β2-M expression may contribute to the oncogenesis of human oral mucosa, tumor invasion and metastasis.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Imai T, Toyota M, Suzuki H, et al: Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma. Cancer Sci. 99:958–966. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Scully C and Bagan JV: Recent advances in Oral Oncology 2007: imaging, treatment and treatment outcomes. Oral Oncol. 44:211–215. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Cai ZG, Shi XJ, Gao Y, Wei MJ, Wang CY and Yu GY: Beta-catenin expression pattern in primary oral squamous cell carcinoma. Chin Med J (Engl). 121:1866–1870. 2008.PubMed/NCBI

4 

Chen CH, Su CY, Chien CY, et al: Overexpression of beta2-microglobulin is associated with poor survival in patients with oral cavity squamous cell carcinoma and contributes to oral cancer cell migration and invasion. Br J Cancer. 99:1453–1461. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Shi C, Zhu Y, Su Y, Chung LW and Cheng T: Beta2-microglobulin: emerging as a promising cancer therapeutic target. Drug Discov Today. 14:25–30. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Winchester JF, Salsberg JA and Levin NW: Beta-2 microglobulin in ESRD: an in-depth review. Adv Ren Replace Ther. 10:279–309. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Margalit A, Sheikhet HM, Carmi Y, et al: Induction of antitumor immunity by CTL epitopes genetically linked to membrane-anchored beta2-microglobulin. J Immunol. 176:217–224. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Christianson GJ, Brooks W, Vekasi S, et al: Beta 2-microglobulin-deficient mice are protected from hypergammaglobulinemia and have defective antibody responses because of increased IgG catabolism. J Immunol. 159:4781–4792. 1997.PubMed/NCBI

9 

Hoglund P, Glas R, Menard C, et al: Beta2-microglobulin-deficient NK cells show increased sensitivity to MHC class I-mediated inhibition, but self tolerance does not depend upon target cell expression of H-2Kb and Db heavy chains. Eur J Immunol. 28:370–378. 1998. View Article : Google Scholar : PubMed/NCBI

10 

Huang WC, Wu D, Xie Z, et al: Beta2-microglobulin is a signaling and growth-promoting factor for human prostate cancer bone metastasis. Cancer Res. 66:9108–9116. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Nomura T, Huang WC, Zhau HE, et al: Beta2-microglobulin promotes the growth of human renal cell carcinoma through the activation of the protein kinase A, cyclic AMP-responsive element-binding protein, and vascular endothelial growth factor axis. Clin Cancer Res. 12:7294–7305. 2006. View Article : Google Scholar

12 

Tsimberidou AM, Kantarjian HM, Wen S, et al: The prognostic significance of serum beta2 microglobulin levels in acute myeloid leukemia and prognostic scores predicting survival: analysis of 1,180 patients. Clin Cancer Res. 14:721–730. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Huang WC, Havel JJ, Zhau HE, et al: Beta2-microglobulin signaling blockade inhibited androgen receptor axis and caused apoptosis in human prostate cancer cells. Clin Cancer Res. 14:5341–5347. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Sdek P, Zhang ZY, Cao J, Pan HY, Chen WT and Zheng JW: Alteration of cell-cycle regulatory proteins in human oral epithelial cells immortalized by HPV16 E6 and E7. Int J Oral Maxillofac Surg. 35:653–657. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Zhang L, Yang X, Zhong LP, et al: Decreased expression of Annexin A1 correlates with pathologic differentiation grade in oral squamous cell carcinoma. J Oral Pathol Med. 38:362–370. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Kageshita T, Hirai S, Ono T, Hicklin DJ and Ferrone S: Down-regulation of HLA class I antigen-processing molecules in malignant melanoma: association with disease progression. Am J Pathol. 154:745–754. 1999. View Article : Google Scholar : PubMed/NCBI

17 

Klein B, Levin I, Kfir B, Mishaeli M, Shapira J and Klein T: The significance of soluble interleukin-2, soluble interleukin-2 receptors, soluble ICAM-1 and beta 2-microglobulin in breast cancer patients. Tumour Biol. 16:290–296. 1995. View Article : Google Scholar : PubMed/NCBI

18 

Freeman MR: Beta2 microglobulin: a surprising therapeutic target for prostate cancer and renal cell carcinoma. J Urol. 178:10–11. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Nissen MH, Bjerrum OJ, Plesner T, Wilken M and Rorth M: Modification of beta-2-microglobulin in sera from patients with small cell lung cancer: evidence for involvement of a serine protease. Clin Exp Immunol. 67:425–432. 1987.PubMed/NCBI

20 

Kaplan B, Martin BM, Livoff A, Yeremenko D, Livneh A and Cohen HIL: Gastrointestinal beta2microglobulin amyloidosis in hemodialysis patients: biochemical analysis of amyloid proteins in small formalin-fixed paraffin-embedded tissue specimens. Mod Pathol. 18:1610–1617. 2005.

21 

Lee JK, Tsai SC, Hsieh JF, Ho YJ, Sun SS and Kao CH: Beta-2-microglobulin (beta 2M) as a tumor marker in nasopharyngeal carcinoma. Anticancer Res. 20:4765–4768. 2000.PubMed/NCBI

22 

Kim JE, Yoo C, Lee DH, Kim SW, Lee JS and Suh C: Serum albumin level is a significant prognostic factor reflecting disease severity in symptomatic multiple myeloma. Ann Hematol. 89:391–397. 2009. View Article : Google Scholar

23 

Delgado J, Pratt G, Phillips N, et al: Beta2-microglobulin is a better predictor of treatment-free survival in patients with chronic lymphocytic leukaemia if adjusted according to glomerular filtration rate. Br J Haematol. 145:801–805. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Federico M, Guglielmi C, Luminari S, et al: Prognostic relevance of serum beta2 microglobulin in patients with follicular lymphoma treated with anthracycline-containing regimens. A GISL study. Haematologica. 92:1482–1488. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Albitar M, Vose JM, Johnson MM, et al: Clinical relevance of soluble HLA-I and beta2-microglobulin levels in non-Hodgkin's lymphoma and Hodgkin's disease. Leuk Res. 31:139–145. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Sousa AO, Mazzaccaro RJ, Russell RG, et al: Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice. Proc Natl Acad Sci USA. 97:4204–4208. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Hicklin DJ, Wang Z, Arienti F, Rivoltini L, Parmiani G and Ferrone S: Beta2-Microglobulin mutations, HLA class I antigen loss, and tumor progression in melanoma. J Clin Invest. 101:2720–2729. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Mehta AM, Jordanova ES, Kenter GG, Ferrone S and Fleuren GJ: Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma. Cancer Immunol Immunother. 57:197–206. 2008. View Article : Google Scholar : PubMed/NCBI

29 

del Campo AB, Aptsiauri N, Mendez R, et al: Efficient recovery of HLA class I expression in human tumor cells after beta2-microglobulin gene transfer using adenoviral vector: implications for cancer immunotherapy. Scand J Immunol. 70:125–135. 2009.PubMed/NCBI

30 

Koene GJ, Arts-Hilkes YH, van der Ven KJ, et al: High level of chromosome 15 aneuploidy in head and neck squamous cell carcinoma lesions identified by FISH analysis: limited value of beta2-microglobulin LOH analysis. Tissue Antigens. 64:452–461. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Feenstra M, Veltkamp M, van Kuik J, et al: HLA class I expression and chromosomal deletions at 6p and 15q in head and neck squamous cell carcinomas. Tissue Antigens. 54:235–245. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Yang J, Qian J, Wezeman M, et al: Targeting beta2-microglobulin for induction of tumor apoptosis in human hematological malignancies. Cancer Cell. 10:295–307. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Yang J, Zhang X, Wang J, et al: Anti-beta2-microglobulin monoclonal antibodies induce apoptosis in myeloma cells by recruiting MHC class I to and excluding growth and survival cytokine receptors from lipid rafts. Blood. 110:3028–3035. 2007. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jiang Q, Patima S, Ye D, Pan H, Zhang P and Zhang Z: Upregulation of β2-microglobulin expression in progressive human oral squamous cell carcinoma. Oncol Rep 27: 1058-1064, 2012.
APA
Jiang, Q., Patima, S., Ye, D., Pan, H., Zhang, P., & Zhang, Z. (2012). Upregulation of β2-microglobulin expression in progressive human oral squamous cell carcinoma. Oncology Reports, 27, 1058-1064. https://doi.org/10.3892/or.2011.1613
MLA
Jiang, Q., Patima, S., Ye, D., Pan, H., Zhang, P., Zhang, Z."Upregulation of β2-microglobulin expression in progressive human oral squamous cell carcinoma". Oncology Reports 27.4 (2012): 1058-1064.
Chicago
Jiang, Q., Patima, S., Ye, D., Pan, H., Zhang, P., Zhang, Z."Upregulation of β2-microglobulin expression in progressive human oral squamous cell carcinoma". Oncology Reports 27, no. 4 (2012): 1058-1064. https://doi.org/10.3892/or.2011.1613
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Q, Patima S, Ye D, Pan H, Zhang P and Zhang Z: Upregulation of β2-microglobulin expression in progressive human oral squamous cell carcinoma. Oncol Rep 27: 1058-1064, 2012.
APA
Jiang, Q., Patima, S., Ye, D., Pan, H., Zhang, P., & Zhang, Z. (2012). Upregulation of β2-microglobulin expression in progressive human oral squamous cell carcinoma. Oncology Reports, 27, 1058-1064. https://doi.org/10.3892/or.2011.1613
MLA
Jiang, Q., Patima, S., Ye, D., Pan, H., Zhang, P., Zhang, Z."Upregulation of β2-microglobulin expression in progressive human oral squamous cell carcinoma". Oncology Reports 27.4 (2012): 1058-1064.
Chicago
Jiang, Q., Patima, S., Ye, D., Pan, H., Zhang, P., Zhang, Z."Upregulation of β2-microglobulin expression in progressive human oral squamous cell carcinoma". Oncology Reports 27, no. 4 (2012): 1058-1064. https://doi.org/10.3892/or.2011.1613
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team