Upregulation of β2-microglobulin expression in progressive human oral squamous cell carcinoma

  • Authors:
    • Qian Jiang
    • Sdek Patima
    • Dong-Xia Ye
    • Hong-Ya Pan
    • Pin Zhang
    • Zhi-Yuan Zhang
  • View Affiliations

  • Published online on: December 30, 2011     https://doi.org/10.3892/or.2011.1613
  • Pages: 1058-1064
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Abstract

The aim of the present study was to investigate β2-microglobulin (β2-M) expression in normal oral mucosa and progressive oral squamous cell carcinoma (OSCC) and to assess the clinical significance of β2-microglobulin expression. The study included 10 cases of normal oral mucosa epithelium specimens, 55 cases of primary OSCC specimens, and 25 cases of OSCC metastasis specimens. Immunohistochemistry was used to determine β2-M expression, and its correlation with clinicopathological factors in progressive OSCC was evaluated. Immunohistochemistry showed that strong β2-M expression was significantly asscociated with tumor size (T3, T4 vs. T1, T2; P=0.001), positive node status (N positive vs. N negative; P=0.000) and advanced clinical stage (Ⅲ, Ⅳ vs. Ⅰ, Ⅱ, P=0.000) in primary OSCC lesions. Compared to primary OSCC lesions, the frequency of β2-M expression was significantly increased in metastatic OSCC lesions (P=0.02). In addition, in vitro results from Western blotting showed increased β2-M expression in the two OSCC lines studied. Therefore, we speculate that the up-regulation of β2-M expression may contribute to the oncogenesis of human oral mucosa, tumor invasion and metastasis.
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April 2012
Volume 27 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Jiang Q, Patima S, Ye D, Pan H, Zhang P and Zhang Z: Upregulation of β2-microglobulin expression in progressive human oral squamous cell carcinoma. Oncol Rep 27: 1058-1064, 2012
APA
Jiang, Q., Patima, S., Ye, D., Pan, H., Zhang, P., & Zhang, Z. (2012). Upregulation of β2-microglobulin expression in progressive human oral squamous cell carcinoma. Oncology Reports, 27, 1058-1064. https://doi.org/10.3892/or.2011.1613
MLA
Jiang, Q., Patima, S., Ye, D., Pan, H., Zhang, P., Zhang, Z."Upregulation of β2-microglobulin expression in progressive human oral squamous cell carcinoma". Oncology Reports 27.4 (2012): 1058-1064.
Chicago
Jiang, Q., Patima, S., Ye, D., Pan, H., Zhang, P., Zhang, Z."Upregulation of β2-microglobulin expression in progressive human oral squamous cell carcinoma". Oncology Reports 27, no. 4 (2012): 1058-1064. https://doi.org/10.3892/or.2011.1613