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April 2012 Volume 27 Issue 4

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Article

Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells

  • Authors:
    • M. V. Barni
    • M. J. Carlini
    • E. G. Cafferata
    • L. Puricelli
    • S. Moreno
  • View Affiliations / Copyright

    Affiliations: Foundation Institute Leloir, IIBBA-CONICET, CABA 1405 Buenos Aires, Argentina, Foundation Institute Leloir, IIBBA-CONICET, Av. Patricias Argentinas 435, CABA 1405 Buenos Aires, Argentina
  • Pages: 1041-1048
    |
    Published online on: January 11, 2012
       https://doi.org/10.3892/or.2012.1630
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Abstract

Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide. The objective of this study was to examine whether carnosic acid (CA), the main antioxidant compound of Rosmarinus officinalis L., would inhibit the cell viability of three CRC cell lines: Caco-2, HT29 and LoVo in a dose-dependent manner, with IC50 values in the range of 24-96 µM. CA induced cell death by apoptosis in Caco-2 line after 24 h of treatment and inhibited cell adhesion and migration, possibly by reducing the activity of secreted proteases such as urokinase plasminogen activator (uPA) and metalloproteinases (MMPs). These effects may be associated through a mechanism involving the inhibition of the COX-2 pathway, because we have determined that CA downregulates the expression of COX-2 in Caco-2 cells at both the mRNA and protein levels. Therefore, CA modulates different targets involved in the development of CRC. These findings indicate that carnosic acid may have anticancer activity and may be useful as a novel chemotherapeutic agent.
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Copy and paste a formatted citation
Spandidos Publications style
Barni MV, Carlini MJ, Cafferata EG, Puricelli L and Moreno S: Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells. Oncol Rep 27: 1041-1048, 2012.
APA
Barni, M.V., Carlini, M.J., Cafferata, E.G., Puricelli, L., & Moreno, S. (2012). Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells. Oncology Reports, 27, 1041-1048. https://doi.org/10.3892/or.2012.1630
MLA
Barni, M. V., Carlini, M. J., Cafferata, E. G., Puricelli, L., Moreno, S."Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells". Oncology Reports 27.4 (2012): 1041-1048.
Chicago
Barni, M. V., Carlini, M. J., Cafferata, E. G., Puricelli, L., Moreno, S."Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells". Oncology Reports 27, no. 4 (2012): 1041-1048. https://doi.org/10.3892/or.2012.1630
Copy and paste a formatted citation
x
Spandidos Publications style
Barni MV, Carlini MJ, Cafferata EG, Puricelli L and Moreno S: Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells. Oncol Rep 27: 1041-1048, 2012.
APA
Barni, M.V., Carlini, M.J., Cafferata, E.G., Puricelli, L., & Moreno, S. (2012). Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells. Oncology Reports, 27, 1041-1048. https://doi.org/10.3892/or.2012.1630
MLA
Barni, M. V., Carlini, M. J., Cafferata, E. G., Puricelli, L., Moreno, S."Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells". Oncology Reports 27.4 (2012): 1041-1048.
Chicago
Barni, M. V., Carlini, M. J., Cafferata, E. G., Puricelli, L., Moreno, S."Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells". Oncology Reports 27, no. 4 (2012): 1041-1048. https://doi.org/10.3892/or.2012.1630
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