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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2012 Volume 27 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Lycii cortex radicis extract inhibits glioma tumor growth in vitro and in vivo through downregulation of the Akt/ERK pathway

  • Authors:
    • Ji Cheon Jeong
    • Saeng Jae Kim
    • Yong Keun Kim
    • Chae Hwa Kwon
    • Ki Hyung Kim

  • View Affiliations / Copyright

    Affiliations: Department of Oriental Medicine, Dongguk University, Kyung Ju 780-714, Republic of Korea, Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, 1-10 Ami‑Dong, Suh‑Gu, Busan 602‑739, Republic of Korea
  • Pages: 1467-1474
    |
    Published online on: January 16, 2012
       https://doi.org/10.3892/or.2012.1637
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Abstract

Lycii cortex radicis (LCR) is a traditional Korean medicinal herb. The present study was undertaken to examine the effect of an LCR extract on glioma cell growth and to determine its molecular mechanism in U87MG human glioma cells. The LCR extract resulted in apoptotic cell death in a dose- and time-dependent manner. The LCR extract-induced cell death was associated with generation of reactive oxygen species (ROS). Western blot analysis showed that the LCR extract caused downregulation of Akt and ERK. The LCR-induced cell death was prevented by transfection with the constitutively active forms of Akt and MEK. Oral administration of LCR extracts in subcutaneous U87MG xenograft models reduced glioma tumor volume. Taken together, these findings suggest that the LCR extract results in human glioma cell death through mechanisms involving ROS generation, downregulation of Akt and ERK, and caspase activation in vitro and reduces glioma tumor growth in vivo. These data suggest that the LCR extract may serve as a potential therapeutic agent for malignant human glioblastomas.

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Copy and paste a formatted citation
Spandidos Publications style
Jeong JC, Kim SJ, Kim YK, Kwon CH and Kim KH: Lycii cortex radicis extract inhibits glioma tumor growth in vitro and in vivo through downregulation of the Akt/ERK pathway. Oncol Rep 27: 1467-1474, 2012.
APA
Jeong, J.C., Kim, S.J., Kim, Y.K., Kwon, C.H., & Kim, K.H. (2012). Lycii cortex radicis extract inhibits glioma tumor growth in vitro and in vivo through downregulation of the Akt/ERK pathway. Oncology Reports, 27, 1467-1474. https://doi.org/10.3892/or.2012.1637
MLA
Jeong, J. C., Kim, S. J., Kim, Y. K., Kwon, C. H., Kim, K. H."Lycii cortex radicis extract inhibits glioma tumor growth in vitro and in vivo through downregulation of the Akt/ERK pathway". Oncology Reports 27.5 (2012): 1467-1474.
Chicago
Jeong, J. C., Kim, S. J., Kim, Y. K., Kwon, C. H., Kim, K. H."Lycii cortex radicis extract inhibits glioma tumor growth in vitro and in vivo through downregulation of the Akt/ERK pathway". Oncology Reports 27, no. 5 (2012): 1467-1474. https://doi.org/10.3892/or.2012.1637
Copy and paste a formatted citation
x
Spandidos Publications style
Jeong JC, Kim SJ, Kim YK, Kwon CH and Kim KH: Lycii cortex radicis extract inhibits glioma tumor growth in vitro and in vivo through downregulation of the Akt/ERK pathway. Oncol Rep 27: 1467-1474, 2012.
APA
Jeong, J.C., Kim, S.J., Kim, Y.K., Kwon, C.H., & Kim, K.H. (2012). Lycii cortex radicis extract inhibits glioma tumor growth in vitro and in vivo through downregulation of the Akt/ERK pathway. Oncology Reports, 27, 1467-1474. https://doi.org/10.3892/or.2012.1637
MLA
Jeong, J. C., Kim, S. J., Kim, Y. K., Kwon, C. H., Kim, K. H."Lycii cortex radicis extract inhibits glioma tumor growth in vitro and in vivo through downregulation of the Akt/ERK pathway". Oncology Reports 27.5 (2012): 1467-1474.
Chicago
Jeong, J. C., Kim, S. J., Kim, Y. K., Kwon, C. H., Kim, K. H."Lycii cortex radicis extract inhibits glioma tumor growth in vitro and in vivo through downregulation of the Akt/ERK pathway". Oncology Reports 27, no. 5 (2012): 1467-1474. https://doi.org/10.3892/or.2012.1637
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