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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2012 Volume 27 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro

  • Authors:
    • Junkoh Yamamoto
    • Shun-Ichiro Ogura
    • Tohru Tanaka
    • Takehiro Kitagawa
    • Yoshiteru Nakano
    • Takeshi Saito
    • Mayu Takahashi
    • Daisuke Akiba
    • Shigeru Nishizawa

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, University of Occupational and Environmental Health, Fukuoka, Japan, Endowed Research Section (ALA), Frontier Research Center, Tokyo Institute of Technology, Yokohama, Japan, SBI ALApromo Co., Ltd., Tokyo, Japan
  • Pages: 1748-1752
    |
    Published online on: February 28, 2012
       https://doi.org/10.3892/or.2012.1699
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Abstract

5-Aminolevulinic acid (ALA) is a prodrug used in photodynamic therapy and fluorescence-guided resection of malignant gliomas due to its high cellular uptake in tumours. Porphyrin compounds act not only as photosensitizers but also as radiosensitizers. In the present study, the possible use of 5-ALA as a radiosensitizer for malignant gliomas was examined in vitro. Rat glioma cell lines (9L, C6) were pre-treated with 5-ALA and exposed to ionizing irradiation. The radiosensitizing effect of 5-ALA was evaluated by colony-forming assay. Intracellular reactive oxygen species (ROS) produced by 5-ALA and irradiation were evaluated by confocal laser scanning microscopy. Pre-treatment with 5-ALA enhanced the radiosensitivity of 9L cells to single-dose ionizing irradiation compared with controls (D0 value, 4.35±0.20 and 4.84±0.23 Gy, respectively, P≤0.05). Exposure to multi-dose ionizing irradiation revealed high radiosensitivity in both 9L and C6 cells pre-treated with 5-ALA compared to controls. Production of intracellular ROS increased in 9L cells pre-treated with 5-ALA after ionizing irradiation compared to control cells. Thus, 5-ALA functions as a specific radiosensi­tizer for malignant gliomas. Intracellular 5-ALA-induced PpIX plays an important role in the production of ROS and the radiosensitizing effect under ionizing irradiation conditions.

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Copy and paste a formatted citation
Spandidos Publications style
Yamamoto J, Ogura S, Tanaka T, Kitagawa T, Nakano Y, Saito T, Takahashi M, Akiba D and Nishizawa S: Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro. Oncol Rep 27: 1748-1752, 2012.
APA
Yamamoto, J., Ogura, S., Tanaka, T., Kitagawa, T., Nakano, Y., Saito, T. ... Nishizawa, S. (2012). Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro. Oncology Reports, 27, 1748-1752. https://doi.org/10.3892/or.2012.1699
MLA
Yamamoto, J., Ogura, S., Tanaka, T., Kitagawa, T., Nakano, Y., Saito, T., Takahashi, M., Akiba, D., Nishizawa, S."Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro". Oncology Reports 27.6 (2012): 1748-1752.
Chicago
Yamamoto, J., Ogura, S., Tanaka, T., Kitagawa, T., Nakano, Y., Saito, T., Takahashi, M., Akiba, D., Nishizawa, S."Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro". Oncology Reports 27, no. 6 (2012): 1748-1752. https://doi.org/10.3892/or.2012.1699
Copy and paste a formatted citation
x
Spandidos Publications style
Yamamoto J, Ogura S, Tanaka T, Kitagawa T, Nakano Y, Saito T, Takahashi M, Akiba D and Nishizawa S: Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro. Oncol Rep 27: 1748-1752, 2012.
APA
Yamamoto, J., Ogura, S., Tanaka, T., Kitagawa, T., Nakano, Y., Saito, T. ... Nishizawa, S. (2012). Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro. Oncology Reports, 27, 1748-1752. https://doi.org/10.3892/or.2012.1699
MLA
Yamamoto, J., Ogura, S., Tanaka, T., Kitagawa, T., Nakano, Y., Saito, T., Takahashi, M., Akiba, D., Nishizawa, S."Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro". Oncology Reports 27.6 (2012): 1748-1752.
Chicago
Yamamoto, J., Ogura, S., Tanaka, T., Kitagawa, T., Nakano, Y., Saito, T., Takahashi, M., Akiba, D., Nishizawa, S."Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro". Oncology Reports 27, no. 6 (2012): 1748-1752. https://doi.org/10.3892/or.2012.1699
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