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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2012 Volume 27 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Involvement of Mcl1 in diallyl disulfide-induced G2/M cell cycle arrest in HL-60 cells

  • Authors:
    • Lan Yi
    • Xiao-Xia Ji
    • Hui Tan
    • Mei-Yan Feng
    • Yi Tang
    • Ling Wen
    • Qi Su

  • View Affiliations / Copyright

    Affiliations: Cancer Research Institute, University of South China, Hengyang 421001, Hunan Province, P.R. China
  • Pages: 1911-1917
    |
    Published online on: February 28, 2012
       https://doi.org/10.3892/or.2012.1704
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Abstract

Diallyl disulfide (DADS) has shown potential as a therapeutic agent in various cancers. Previously, we found that myeloid cell leukemia sequence 1 (Mcl1) was downregulated in DADS-induced cell cycle arrest in HL-60 human leukemia cells. Here, we investigated the role of this protein in DADS-induced G2/M cell cycle arrest in HL-60 cells. We demonstrated that DADS treatment significantly increased the proportion of G2/M phase HL-60 cells (P<0.05) and caused a time-dependent significant downregulation of Mcl1 and the cell cycle-related proteins PCNA and CDK1 (P<0.05). Small interfering RNA-mediated knockdown of Mcl1 expression in HL-60 cells arrested the cell cycle in G2/M phase. By co-immunoprecipitation, we demonstrated that Mcl1 associated with PCNA and CDK1 in G2/M cell cycle arrest in DADS-treated HL-60 cells. DADS decreased the interaction of Mcl1 with PCNA and CDK1, leading to G2/M cell cycle arrest in HL-60 cells. Mcl1 plays an important role in DADS-induced G2/M cell cycle arrest in HL-60 human leukemia cells.

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Copy and paste a formatted citation
Spandidos Publications style
Yi L, Ji X, Tan H, Feng M, Tang Y, Wen L and Su Q: Involvement of Mcl1 in diallyl disulfide-induced G2/M cell cycle arrest in HL-60 cells. Oncol Rep 27: 1911-1917, 2012.
APA
Yi, L., Ji, X., Tan, H., Feng, M., Tang, Y., Wen, L., & Su, Q. (2012). Involvement of Mcl1 in diallyl disulfide-induced G2/M cell cycle arrest in HL-60 cells. Oncology Reports, 27, 1911-1917. https://doi.org/10.3892/or.2012.1704
MLA
Yi, L., Ji, X., Tan, H., Feng, M., Tang, Y., Wen, L., Su, Q."Involvement of Mcl1 in diallyl disulfide-induced G2/M cell cycle arrest in HL-60 cells". Oncology Reports 27.6 (2012): 1911-1917.
Chicago
Yi, L., Ji, X., Tan, H., Feng, M., Tang, Y., Wen, L., Su, Q."Involvement of Mcl1 in diallyl disulfide-induced G2/M cell cycle arrest in HL-60 cells". Oncology Reports 27, no. 6 (2012): 1911-1917. https://doi.org/10.3892/or.2012.1704
Copy and paste a formatted citation
x
Spandidos Publications style
Yi L, Ji X, Tan H, Feng M, Tang Y, Wen L and Su Q: Involvement of Mcl1 in diallyl disulfide-induced G2/M cell cycle arrest in HL-60 cells. Oncol Rep 27: 1911-1917, 2012.
APA
Yi, L., Ji, X., Tan, H., Feng, M., Tang, Y., Wen, L., & Su, Q. (2012). Involvement of Mcl1 in diallyl disulfide-induced G2/M cell cycle arrest in HL-60 cells. Oncology Reports, 27, 1911-1917. https://doi.org/10.3892/or.2012.1704
MLA
Yi, L., Ji, X., Tan, H., Feng, M., Tang, Y., Wen, L., Su, Q."Involvement of Mcl1 in diallyl disulfide-induced G2/M cell cycle arrest in HL-60 cells". Oncology Reports 27.6 (2012): 1911-1917.
Chicago
Yi, L., Ji, X., Tan, H., Feng, M., Tang, Y., Wen, L., Su, Q."Involvement of Mcl1 in diallyl disulfide-induced G2/M cell cycle arrest in HL-60 cells". Oncology Reports 27, no. 6 (2012): 1911-1917. https://doi.org/10.3892/or.2012.1704
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