A unique MUC1-2-VNTR DNA vaccine suppresses tumor growth and prolongs survival in a murine multiple myeloma model

  • Authors:
    • Yuhui Weng
    • Liang Shao
    • Hongmei Ouyang
    • Yuebo Liu
    • Jin Yao
    • Hong Yang
    • Yunjiao Luo
    • Hao Wang
    • Zhenyu Zhao
    • Hong Mou
    • Zeping Zhou
    • You Zhang
  • View Affiliations

  • Published online on: March 7, 2012     https://doi.org/10.3892/or.2012.1707
  • Pages: 1815-1822
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Abstract

Multiple myeloma (MM) is a clonal B-cell malignancy charactered by the aberrant proliferation of malignant plasma cells in the bone marrow. MM is still an incurable malignancy. In this regard, novel treatments are urgently required. MUC1 (mucin 1), a type І transmembrane protein, is overexpressed and aberrantly glycosylated in many carcinomas particularly in MM resulting in an antigenically distinct molecule and may be a potential target for specific immunotherapy. In this study, we first designed a unique DNA vaccine, termed MUC1-2-VNTR (various number tandem repeats) to investigate whether the vaccine could specifically suppress tumor growth in a murine multiple myloma model. Our results showed that the constructed DNA vaccine pcDNA3.1-VNTR elicited both humoral and cellular tumor-specific immune responses in the MM mouse model leading to delay in tumor growth and prolonged survival of the mice. Consequently, our study indicates that this DNA vaccine shows promise to be used as a novel strategy for the treatment of MM.

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June 2012
Volume 27 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Weng Y, Shao L, Ouyang H, Liu Y, Yao J, Yang H, Luo Y, Wang H, Zhao Z, Mou H, Mou H, et al: A unique MUC1-2-VNTR DNA vaccine suppresses tumor growth and prolongs survival in a murine multiple myeloma model. Oncol Rep 27: 1815-1822, 2012
APA
Weng, Y., Shao, L., Ouyang, H., Liu, Y., Yao, J., Yang, H. ... Zhang, Y. (2012). A unique MUC1-2-VNTR DNA vaccine suppresses tumor growth and prolongs survival in a murine multiple myeloma model. Oncology Reports, 27, 1815-1822. https://doi.org/10.3892/or.2012.1707
MLA
Weng, Y., Shao, L., Ouyang, H., Liu, Y., Yao, J., Yang, H., Luo, Y., Wang, H., Zhao, Z., Mou, H., Zhou, Z., Zhang, Y."A unique MUC1-2-VNTR DNA vaccine suppresses tumor growth and prolongs survival in a murine multiple myeloma model". Oncology Reports 27.6 (2012): 1815-1822.
Chicago
Weng, Y., Shao, L., Ouyang, H., Liu, Y., Yao, J., Yang, H., Luo, Y., Wang, H., Zhao, Z., Mou, H., Zhou, Z., Zhang, Y."A unique MUC1-2-VNTR DNA vaccine suppresses tumor growth and prolongs survival in a murine multiple myeloma model". Oncology Reports 27, no. 6 (2012): 1815-1822. https://doi.org/10.3892/or.2012.1707