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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2012 Volume 27 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Transcriptional upregulation of HER2 expression in the absence of HER2 gene amplification results in cetuximab resistance that is reversed by trastuzumab treatment

  • Authors:
    • Cristina Oliveras-Ferraros
    • Anna Massaguer Vall-Llovera
    • Alejandro Vazquez-Martin
    • Dolors Carrion Salip
    • Bernardo Queralt
    • Silvia Cufí
    • Begoña Martin-Castillo
    • Joaquim Bosch-Barrera
    • Joan Brunet
    • Rafael De Llorens
    • Javier A. Menendez
  • View Affiliations / Copyright

    Affiliations: Translational Research Laboratory, Catalan Institute of Oncology (ICO), Girona, Catalonia, Spain, Biochemistry and Molecular Biology Unit, Department of Biology, University of Girona, Girona, Catalonia, Spain, Girona Biomedical Research Institute (IdIBGi), Girona, Catalonia, Spain
  • Pages: 1887-1892
    |
    Published online on: March 15, 2012
       https://doi.org/10.3892/or.2012.1732
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Abstract

The recent identification of HER2 gene amplification as a novel predictor of resistance to the EGFR (HER2)-targeted antibody cetuximab and of response to combination therapies against EGFR and HER2 in wild-type KRAS tumor settings may represent a further step toward personalized medicine for patients with colorectal cancer. Herein, we show that transcriptional upregulation of HER2 expression in the absence of HER2 gene amplification is a molecular phenomenon that takes place in EGFR-dependent, wild-type KRAS squamous cell carcinoma (SCC) cells that acquire resistance to cetuximab. Since cetuximab activity against cetuximab-refractory SCC cells can be fully restored in the presence of the anti-HER2 monoclonal antibody trastuzumab, our findings suggest that, beyond HER2 gene amplification, we might need to redefine the threshold values for HER2 positivity to improve the accuracy of the selection of cetuximab-refractory patients with wild-type KRAS that may benefit from receiving a cetuximab/trastuzumab combination.

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Copy and paste a formatted citation
Spandidos Publications style
Oliveras-Ferraros C, Vall-Llovera AM, Vazquez-Martin A, Salip DC, Queralt B, Cufí S, Martin-Castillo B, Bosch-Barrera J, Brunet J, De Llorens R, De Llorens R, et al: Transcriptional upregulation of HER2 expression in the absence of HER2 gene amplification results in cetuximab resistance that is reversed by trastuzumab treatment. Oncol Rep 27: 1887-1892, 2012.
APA
Oliveras-Ferraros, C., Vall-Llovera, A.M., Vazquez-Martin, A., Salip, D.C., Queralt, B., Cufí, S. ... Menendez, J.A. (2012). Transcriptional upregulation of HER2 expression in the absence of HER2 gene amplification results in cetuximab resistance that is reversed by trastuzumab treatment. Oncology Reports, 27, 1887-1892. https://doi.org/10.3892/or.2012.1732
MLA
Oliveras-Ferraros, C., Vall-Llovera, A. M., Vazquez-Martin, A., Salip, D. C., Queralt, B., Cufí, S., Martin-Castillo, B., Bosch-Barrera, J., Brunet, J., De Llorens, R., Menendez, J. A."Transcriptional upregulation of HER2 expression in the absence of HER2 gene amplification results in cetuximab resistance that is reversed by trastuzumab treatment". Oncology Reports 27.6 (2012): 1887-1892.
Chicago
Oliveras-Ferraros, C., Vall-Llovera, A. M., Vazquez-Martin, A., Salip, D. C., Queralt, B., Cufí, S., Martin-Castillo, B., Bosch-Barrera, J., Brunet, J., De Llorens, R., Menendez, J. A."Transcriptional upregulation of HER2 expression in the absence of HER2 gene amplification results in cetuximab resistance that is reversed by trastuzumab treatment". Oncology Reports 27, no. 6 (2012): 1887-1892. https://doi.org/10.3892/or.2012.1732
Copy and paste a formatted citation
x
Spandidos Publications style
Oliveras-Ferraros C, Vall-Llovera AM, Vazquez-Martin A, Salip DC, Queralt B, Cufí S, Martin-Castillo B, Bosch-Barrera J, Brunet J, De Llorens R, De Llorens R, et al: Transcriptional upregulation of HER2 expression in the absence of HER2 gene amplification results in cetuximab resistance that is reversed by trastuzumab treatment. Oncol Rep 27: 1887-1892, 2012.
APA
Oliveras-Ferraros, C., Vall-Llovera, A.M., Vazquez-Martin, A., Salip, D.C., Queralt, B., Cufí, S. ... Menendez, J.A. (2012). Transcriptional upregulation of HER2 expression in the absence of HER2 gene amplification results in cetuximab resistance that is reversed by trastuzumab treatment. Oncology Reports, 27, 1887-1892. https://doi.org/10.3892/or.2012.1732
MLA
Oliveras-Ferraros, C., Vall-Llovera, A. M., Vazquez-Martin, A., Salip, D. C., Queralt, B., Cufí, S., Martin-Castillo, B., Bosch-Barrera, J., Brunet, J., De Llorens, R., Menendez, J. A."Transcriptional upregulation of HER2 expression in the absence of HER2 gene amplification results in cetuximab resistance that is reversed by trastuzumab treatment". Oncology Reports 27.6 (2012): 1887-1892.
Chicago
Oliveras-Ferraros, C., Vall-Llovera, A. M., Vazquez-Martin, A., Salip, D. C., Queralt, B., Cufí, S., Martin-Castillo, B., Bosch-Barrera, J., Brunet, J., De Llorens, R., Menendez, J. A."Transcriptional upregulation of HER2 expression in the absence of HER2 gene amplification results in cetuximab resistance that is reversed by trastuzumab treatment". Oncology Reports 27, no. 6 (2012): 1887-1892. https://doi.org/10.3892/or.2012.1732
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