CC chemokine ligand 7 expression in liver metastasis of colorectal cancer

  • Authors:
    • Yong Beom Cho
    • Woo Yong Lee
    • So-Jung Choi
    • Jhingook Kim
    • Hye Kyung Hong
    • Seok-Hyung Kim
    • Yoon-La Choi
    • Hee Cheol Kim
    • Seong Hyeon Yun
    • Ho-Kyung Chun
    • Kuhn Uk Lee
  • View Affiliations

  • Published online on: May 14, 2012     https://doi.org/10.3892/or.2012.1815
  • Pages: 689-694
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Abstract

The main cause of death for colorectal cancer (CRC) patients is the development of metastatic lesions at sites distant from the primary tumor. Therefore, it is important to find biomarkers that are related to the metastasis and to study the possible mechanisms. Recent data have shown that soluble attractant molecules called chemokines support the metastasis of certain cancers to certain organs. To identify molecular regulators that are differentially expressed in liver metastasis of CRC, PCR array analysis was performed and CC chemokine ligand 7 (CCL7) showed remarkable overexpression in liver metastatic tumor tissues. To validate the results of the PCR array, 30 patients with primary CRC and liver metastases were selected. Immunohistochemistry and real-time PCR analysis showed that CCL7 was expressed in normal colonic epithelium and the expression was higher in liver metastases compared to primary CRC (p<0.001). Real-time PCR showed that the expression of CCR1, CCR2 and CCR3 was also higher in liver metastases compared to primary CRC (p=0.001, p=0.033 and p<0.001, respectively). In conclusion, correlation of CCL7 overexpression and its receptor expression with colon cancer liver metastasis suggests that CCL7 as a novel target in liver metastasis of CRC may be of potential clinical value for the prevention of hepatic recurrences.
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August 2012
Volume 28 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Cho YB, Lee WY, Choi S, Kim J, Hong HK, Kim S, Choi Y, Kim HC, Yun SH, Chun H, Chun H, et al: CC chemokine ligand 7 expression in liver metastasis of colorectal cancer. Oncol Rep 28: 689-694, 2012
APA
Cho, Y.B., Lee, W.Y., Choi, S., Kim, J., Hong, H.K., Kim, S. ... Lee, K.U. (2012). CC chemokine ligand 7 expression in liver metastasis of colorectal cancer. Oncology Reports, 28, 689-694. https://doi.org/10.3892/or.2012.1815
MLA
Cho, Y. B., Lee, W. Y., Choi, S., Kim, J., Hong, H. K., Kim, S., Choi, Y., Kim, H. C., Yun, S. H., Chun, H., Lee, K. U."CC chemokine ligand 7 expression in liver metastasis of colorectal cancer". Oncology Reports 28.2 (2012): 689-694.
Chicago
Cho, Y. B., Lee, W. Y., Choi, S., Kim, J., Hong, H. K., Kim, S., Choi, Y., Kim, H. C., Yun, S. H., Chun, H., Lee, K. U."CC chemokine ligand 7 expression in liver metastasis of colorectal cancer". Oncology Reports 28, no. 2 (2012): 689-694. https://doi.org/10.3892/or.2012.1815