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August 2012 Volume 28 Issue 2

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Article

Efficacy and safety of first-line erlotinib in elderly patients with advanced non-small cell lung cancer

  • Authors:
    • Ofer Merimsky
    • Chi-Kin Cheng
    • Joseph Siu-Kie Au
    • Joachim von Pawel
    • Martin Reck
  • View Affiliations / Copyright

    Affiliations: Division of Oncology, Tel Aviv Medical Center, Tel-Aviv 64239, Israel, Department of Oncology, Princess Margaret Hospital, Lai Chi Kok, Hong Kong, P.R. China, Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong, P.R. China, Department of Oncology, Asklepios Fachkliniken, D-82131 Gauting, Germany, Department of Thoracic Oncology, Krankenhaus Grosshansdorf, D-22927 Grosshansdorf, Germany
  • Pages: 721-727
    |
    Published online on: May 18, 2012
       https://doi.org/10.3892/or.2012.1824
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Abstract

Tarceva Lung cancer Survival Treatment (TRUST) was an open-label, phase IV study of advanced non-small cell lung cancer (NSCLC). Patients failing or unsuitable for chemotherapy or radiotherapy received erlotinib 150 mg/day until progression. We examined a subpopulation of elderly patients (≥70 years) receiving first-line erlotinib (n=485) in TRUST. In this subpopulation, disease control rate (n=356 with best response data available) was 79% (vs. 69% for the overall TRUST population; p<0.0001); median progression-free survival (PFS) was 4.57 months [95% confidence interval (CI), 3.68-5.22]; median overall survival (OS) was 7.29 months (95% CI, 6.27-8.67); and one-year survival, was 36.6%. PFS and OS were significantly longer in patients developing rash, compared to those without, and in those with good performance status (PS; 0/1), compared to poor PS (≥2). Eighty-seven subpopulation patients (18%) had an erlotinib-related AE; other than the protocol-defined frequent adverse events (AEs); 4% had a grade ≥3 erlotinib-related AE, 7% had an erlotinib-related serious AE. In the subpopulation, dose reductions were required in 27%, most (97%) were reductions to 100 mg/day; treatment was discontinued in 10%, and one death was associated with treatment-related toxicity (<1%). Erlotinib was effective and well-tolerated and may be considered for elderly patients with advanced NSCLC who are unsuitable for standard first-line chemotherapy or radiotherapy.
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Copy and paste a formatted citation
Spandidos Publications style
Merimsky O, Cheng C, Au JS, von Pawel J and Reck M: Efficacy and safety of first-line erlotinib in elderly patients with advanced non-small cell lung cancer. Oncol Rep 28: 721-727, 2012.
APA
Merimsky, O., Cheng, C., Au, J.S., von Pawel, J., & Reck, M. (2012). Efficacy and safety of first-line erlotinib in elderly patients with advanced non-small cell lung cancer. Oncology Reports, 28, 721-727. https://doi.org/10.3892/or.2012.1824
MLA
Merimsky, O., Cheng, C., Au, J. S., von Pawel, J., Reck, M."Efficacy and safety of first-line erlotinib in elderly patients with advanced non-small cell lung cancer". Oncology Reports 28.2 (2012): 721-727.
Chicago
Merimsky, O., Cheng, C., Au, J. S., von Pawel, J., Reck, M."Efficacy and safety of first-line erlotinib in elderly patients with advanced non-small cell lung cancer". Oncology Reports 28, no. 2 (2012): 721-727. https://doi.org/10.3892/or.2012.1824
Copy and paste a formatted citation
x
Spandidos Publications style
Merimsky O, Cheng C, Au JS, von Pawel J and Reck M: Efficacy and safety of first-line erlotinib in elderly patients with advanced non-small cell lung cancer. Oncol Rep 28: 721-727, 2012.
APA
Merimsky, O., Cheng, C., Au, J.S., von Pawel, J., & Reck, M. (2012). Efficacy and safety of first-line erlotinib in elderly patients with advanced non-small cell lung cancer. Oncology Reports, 28, 721-727. https://doi.org/10.3892/or.2012.1824
MLA
Merimsky, O., Cheng, C., Au, J. S., von Pawel, J., Reck, M."Efficacy and safety of first-line erlotinib in elderly patients with advanced non-small cell lung cancer". Oncology Reports 28.2 (2012): 721-727.
Chicago
Merimsky, O., Cheng, C., Au, J. S., von Pawel, J., Reck, M."Efficacy and safety of first-line erlotinib in elderly patients with advanced non-small cell lung cancer". Oncology Reports 28, no. 2 (2012): 721-727. https://doi.org/10.3892/or.2012.1824
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