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Review

Targeted molecular therapies for ovarian cancer: an update and future perspectives (Review)

  • Authors:
    • Hiroshi Shigetomi
    • Yumi Higashiura
    • Hirotaka Kajihara
    • Hiroshi Kobayashi
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Nara Medical University, Nara 634-8522, Japan
  • Pages: 395-408
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    Published online on: May 25, 2012
       https://doi.org/10.3892/or.2012.1833
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Abstract

Identification of the potential gene expression profiles of epithelial ovarian cancer and the arrival of newly targeted therapies have advanced the strategies used for treatment of this disease. This review focuses on the design of ongoing and planned clinical trials and offers a synopsis of the English-language literature for preclinical and clinical targeted therapies for epithelial ovarian cancer. Among many targeted agents, a promising, novel class of targeted drugs for special patient populations expected to improve the effectiveness of current therapy include inhibitors of angiogenesis, poly (ADP ribose) polymerase (PARP) and DNA repair mechanisms. Inhibition of PARP or homologous recombination (HR) repair mediated by Chk1 (checkpoint kinase 1) would selectively sensitize p53 mutation, BRCAness phenotype (serous type ovarian cancer) or HNF (hepatocyte nuclear factor)-1β-overexpressing tumor cells (clear cell type ovarian cancer) to chemotherapeutic agents. The therapeutic response is likely to be limited to a targeted patient, but not to the broad population. This review discusses some of the key current developments and existing challenges.
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Copy and paste a formatted citation
Spandidos Publications style
Shigetomi H, Higashiura Y, Kajihara H and Kobayashi H: Targeted molecular therapies for ovarian cancer: an update and future perspectives (Review). Oncol Rep 28: 395-408, 2012.
APA
Shigetomi, H., Higashiura, Y., Kajihara, H., & Kobayashi, H. (2012). Targeted molecular therapies for ovarian cancer: an update and future perspectives (Review). Oncology Reports, 28, 395-408. https://doi.org/10.3892/or.2012.1833
MLA
Shigetomi, H., Higashiura, Y., Kajihara, H., Kobayashi, H."Targeted molecular therapies for ovarian cancer: an update and future perspectives (Review)". Oncology Reports 28.2 (2012): 395-408.
Chicago
Shigetomi, H., Higashiura, Y., Kajihara, H., Kobayashi, H."Targeted molecular therapies for ovarian cancer: an update and future perspectives (Review)". Oncology Reports 28, no. 2 (2012): 395-408. https://doi.org/10.3892/or.2012.1833
Copy and paste a formatted citation
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Spandidos Publications style
Shigetomi H, Higashiura Y, Kajihara H and Kobayashi H: Targeted molecular therapies for ovarian cancer: an update and future perspectives (Review). Oncol Rep 28: 395-408, 2012.
APA
Shigetomi, H., Higashiura, Y., Kajihara, H., & Kobayashi, H. (2012). Targeted molecular therapies for ovarian cancer: an update and future perspectives (Review). Oncology Reports, 28, 395-408. https://doi.org/10.3892/or.2012.1833
MLA
Shigetomi, H., Higashiura, Y., Kajihara, H., Kobayashi, H."Targeted molecular therapies for ovarian cancer: an update and future perspectives (Review)". Oncology Reports 28.2 (2012): 395-408.
Chicago
Shigetomi, H., Higashiura, Y., Kajihara, H., Kobayashi, H."Targeted molecular therapies for ovarian cancer: an update and future perspectives (Review)". Oncology Reports 28, no. 2 (2012): 395-408. https://doi.org/10.3892/or.2012.1833
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