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Article

Characterization of giant marker and ring chromosomes in a pleomorphic leiomyosarcoma of soft tissue by spectral karyotyping

  • Authors:
    • Jun Nishio
    • Mikiko Aoki
    • Kazuki Nabeshima
    • Hiroshi Iwasaki
    • Masatoshi Naito
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan, Department of Pathology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
  • Pages: 533-538
    |
    Published online on: May 25, 2012
       https://doi.org/10.3892/or.2012.1835
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Abstract

Pleomorphic leiomyosarcoma of soft tissue is relatively rare and its cytogenetic and molecular genetic data are scarce. We present a case of pleomorphic leiomyosarcoma arising in the left thigh of a 60-year-old man. Fluorine-18-deoxyglucose positron emission tomography imaging showed a homogenously high uptake within the mass in the proximal left thigh (maximum standardized uptake value, 20.9). Following a core needle biopsy, wide resection of the tumor was performed. Histologically, the tumor was composed of a mixture of spindle cells, polygonal cells and bizarre giant cells forming interlacing bundles and a storiform pattern. Immunohistochemically, the tumor cells were positive for vimentin, smooth muscle actin and desmin. The MIB-1 labeling index was 19.7% in the highest spot. Cytogenetic analysis exhibited a complex karyotype with several numerical and structural alterations, including giant marker and ring chromosomes. Spectral karyotyping demonstrated that giant marker and ring chromosomes were composed of material from the X chromosome. Metaphase-based comparative genomic hybridization analysis showed high-level amplifications of 1q21-q25 and 12q13-q21 and gains of 1p31-p32, 10p11-p13, 17p11 and 19p13. The patient received postoperative adjuvant radiotherapy and doxorubicin-based chemotherapy. No local recurrence or distant metastasis was detected during a follow-up period of 19 months. The clinicopathological, cytogenetic and molecular genetic features of pleomorphic soft tissue leiomyosarcoma are discussed.
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View References

1 

Oda Y, Miyajima K, Kawaguchi K, Tamiya S, Oshiro Y, Hachitanda Y, Oya M, Iwamoto Y and Tsuneyoshi M: Pleomorphic leiomyosarcoma: clinicopathologic and immunohistochemical study with special emphasis on its distinction from ordinary leiomyosarcoma and malignant fibrous histiocytoma. Am J Surg Pathol. 25:1030–1038. 2001. View Article : Google Scholar

2 

Nicolas MM, Tamboli P, Gomez JA and Czerniak BA: Pleomorphic and dedifferentiated leiomyosarcoma: clinicopathologic and immunohistochemical study of 41 cases. Hum Pathol. 41:663–671. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Mertens F, Fletcher CD, Dal Cin P, De Wever I, Mandahl N, Mitelman F, Rosai J, Rydholm A, Sciot R, Tallini G, et al: Cytogenetic analysis of 46 pleomorphic soft tissue sarcomas and correlation with morphologic and clinical features: a report of the CHAMP Study Group. Genes Chromosomes Cancer. 22:16–25. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Mandahl N, Fletcher CD, Dal Cin P, De Wever I, Mertens F, Mitelman F, Rosai J, Rydholm A, Sciot R, Tallini G, et al: Comparative cytogenetic study of spindle cell and pleomorphic leiomyosarcomas of soft tissues: a report from the CHAMP Study Group. Cancer Genet Cytogenet. 116:66–73. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Sandberg AA: Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: leiomyosarcoma. Cancer Genet Cytogenet. 161:1–19. 2005. View Article : Google Scholar

6 

El-Rifai W, Sarlomo-Rikala M, Knuutila S and Miettinen M: DNA copy number changes in development and progression in leiomyosarcomas of soft tissues. Am J Pathol. 153:985–990. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Wang R, Lu YJ, Fisher C, Bridge JA and Shipley J: Characterization of chromosome aberrations associated with soft-tissue leiomyosarcomas by twenty-four-color karyotyping and comparative genomic hybridization analysis. Genes Chromosomes Cancer. 31:54–64. 2001. View Article : Google Scholar

8 

Derré J, Lagacé R, Nicolas A, Mairal A, Chibon F, Coindre JM, Terrier P, Sastre X and Aurias A: Leiomyosarcomas and most malignant fibrous histiocytomas share very similar comparative genomic hybridization imbalances: an analysis of a series of 27 leiomyosarcomas. Lab Invest. 81:211–215. 2001.

9 

Evans HL and Shipley J: Leiomyosarcoma. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Soft Tissue and Bone. Fletcher CDM, Unni KK and Mertens F: IARC Press; Lyon: pp. 131–134. 2002

10 

Wang R, Titley JC, Lu YJ, Summersgill BM, Bridge JA, Fisher C and Shipley J: Loss of 13q14-q21 and gain of 5p14-pter in the progression of leiomyosarcoma. Mod Pathol. 16:778–785. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Hu J, Rao UN, Jasani S, Khanna V, Yaw K and Surti U: Loss of DNA copy number of 10q is associated with aggressive behavior of leiomyosarcomas: a comparative genomic hybridization study. Cancer Genet Cytogenet. 161:20–27. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Larramendy ML, Kaur S, Svarvar C, Böhling T and Knuutila S: Gene copy number profiling of soft-tissue leiomyosarcomas by array-comparative genomic hybridization. Cancer Genet Cytogenet. 169:94–101. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Yang J, Du X, Chen K, Ylipää A, Lazar AJ, Trent J, Lev D, Pollock R, Hao X, Hunt K and Zhang W: Genetic aberrations in soft tissue leiomyosarcoma. Cancer Lett. 275:1–8. 2009. View Article : Google Scholar

14 

Nishio J, Aoki M, Nabeshima K, Iwasaki H and Naito M: Cytogenetic and molecular cytogenetic findings in giant dedifferentiated liposarcoma of the thigh. Oncol Rep. 27:764–768. 2012.PubMed/NCBI

15 

Shaffer LG, Slovak ML and Campbell LJ: ISCN (2009): An International System for Human Cytogenetic Nomenclature. Karger; Basel: 2009

16 

Nishio J, Iwasaki H, Althof PA, Naumann S, Ishiguro M, Haraoka S, Iwashita A, Iwasaki A, Kaku Y, Kaneko Y, et al: Identification of a ring chromosome with spectral karyotyping in a pleural synovial sarcoma. Cancer Genet Cytogenet. 160:174–178. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Nishio J, Iwasaki H, Ohjimi Y, Ishiguro M, Koga T, Isayama T, Naito M and Kikuchi M: Gain of Xq detected by comparative genomic hybridization in elastofibroma. Int J Mol Med. 10:277–280. 2002.PubMed/NCBI

18 

Fletcher CDM: Pleomorphic malignant fibrous histiocytoma: fact or fiction? A critical reappraisal based on 159 tumors diagnosed as pleomorphic sarcoma. Am J Surg Pathol. 16:213–218. 1992. View Article : Google Scholar

19 

Chen E, O’Connell F and Fletcher CDM: Dedifferentiated leiomyosarcoma: clinicopathological analysis of 18 cases. Histopathology. 59:1135–1143. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Nishio J: Contributions of cytogenetics and molecular cytogenetics to the diagnosis of adipocytic tumors. J Biomed Biotechnol. 2011:5240672011. View Article : Google Scholar : PubMed/NCBI

21 

Otaño-Joos M, Mechtersheimer G, Ohl S, Wilgenbus KK, Scheurlen W, Lehnert T, Willeke F, Otto HF, Lichter P and Joos S: Detection of chromosomal imbalances in leiomyosarcoma by comparative genomic hybridization and interphase cytogenetics. Cytogenet Cell Genet. 90:86–92. 2000.PubMed/NCBI

22 

Levy B, Mukherjee T and Hirschhorn K: Molecular cytogenetic analysis of uterine leiomyoma and leiomyosarcoma by comparative genomic hybridization. Cancer Genet Cytogenet. 121:1–8. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Hu J, Khanna V, Jones M and Surti U: Genomic alterations in uterine leiomyosarcomas: potential markers for clinical diagnosis and prognosis. Genes Chromosomes Cancer. 31:117–124. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Gisselsson D, Björk J, Höglund M, Mertens F, Dal Cin P, Akerman M and Mandahl N: Abnormal nuclear shape in solid tumors reflects mitotic instability. Am J Pathol. 158:199–206. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Iwasaki H, Nabeshima K, Nishio J, Jimi S, Aoki M, Koga K, Hamasaki M, Hayashi H and Mogi A: Pathology of soft-tissue tumors: daily diagnosis, molecular cytogenetics and experimental approach. Pathol Int. 59:501–521. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Gisselsson D, Jonson T, Petersén A, Strömbeck B, Dal Cin P, Höglund M, Mitelman F, Mertens F and Mandahl N: Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors. Proc Natl Acad Sci USA. 98:12683–12688. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Forus A, Weghuis DO, Smeets D, Fodstad O, Myklebost O and van Kessel AG: Comparative genomic hybridization analysis of human sarcomas: I. Occurrence of genomic imbalances and identification of a novel major amplicon at 1q21-q22 in soft tissue sarcomas. Genes Chromosomes Cancer. 14:8–14. 1995. View Article : Google Scholar

28 

Nilsson M, Meza-Zepeda LA, Mertens F, Forus A, Myklebost O and Mandahl N: Amplification of chromosome 1 sequences in lipomatous tumors and other sarcomas. Int J Cancer. 109:363–369. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Forus A, D’Angelo A, Henriksen J, Merla G, Maelandsmo GM, Flørenes VA, Olivieri S, Bjerkehagen B, Meza-Zepeda LA, del Vecchio Blanco F, et al: Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas - a possible mechanism for altering the nm23-H1 activity. Oncogene. 20:6881–6890. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Ragazzini P, Gamberi G, Pazzaglia L, Serra M, Magagnoli G, Ponticelli F, Ferrari C, Ghinelli C, Alberghini M, Bertoni F, et al: Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma. Histol Histopathol. 19:401–411. 2004.PubMed/NCBI

31 

Meza-Zepeda LA, Kresse SH, Barragan-Polania AH, Bjerkehagen B, Ohnstad HO, Namløs HM, Wang J, Kristiansen BE and Myklebost O: Array comparative genomic hybridization reveals distinct DNA copy number differences between gastrointestinal stromal tumors and leiomyosarcomas. Cancer Res. 66:8984–8993. 2006. View Article : Google Scholar

32 

Pérot G, Derré J, Coindre JM, Tirode F, Lucchesi C, Mariani O, Gibault L, Guillou L, Terrier P and Aurias A: Strong smooth muscle differentiation is dependent on myocardin gene amplification in most human retroperitoneal leiomyosarcomas. Cancer Res. 69:2269–2278. 2009.PubMed/NCBI

33 

Du KL, Ip HS, Li J, Chen M, Dandre F, Yu W, Lu MM, Owens GK and Parmacek MS: Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. Mol Cell Biol. 23:2425–2437. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Wang Z, Wang DZ, Pipes GC and Olson EN: Myocardin is a master regulator of smooth muscle gene expression. Proc Natl Acad Sci USA. 100:7129–7134. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Pipes GC, Creemers EE and Olson EN: The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis. Genes Dev. 20:1545–1556. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Gill S, Stratton MR, Patterson H, Spurr NK, Fisher C, Gusterson BA and Cooper CS: Detection of transforming genes by transfection of DNA from primary soft-tissue tumours. Oncogene. 6:1651–1656. 1991.PubMed/NCBI

37 

Pryor JG, Brown-Kipphut BA, Iqbal A and Scott GA: Microarray comparative genomic hybridization detection of copy number changes in desmoplastic melanoma and malignant peripheral nerve sheath tumor. Am J Dermatopathol. 33:780–785. 2011. View Article : Google Scholar

38 

Bellavia D, Checquolo S, Campese AF, Felli MP, Gulino A and Screpanti I: Notch3: from subtle structural differences to functional diversity. Oncogene. 27:5092–5098. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Choong PF, Mandahl N, Mertens F, Willén H, Alvegård T, Kreicbergs A, Mitelman F and Rydholm A: 19p+ marker chromosome correlates with relapse in malignant fibrous histiocytoma. Genes Chromosomes Cancer. 16:88–93. 1996.

40 

Larramendy ML, Gentile M, Soloneski S, Knuutila S and Böhling T: Does comparative genomic hybridization reveal distinct differences in DNA copy number sequence patterns between leiomyosarcoma and malignant fibrous histiocytoma? Cancer Genet Cytogenet. 187:1–11. 2008. View Article : Google Scholar

41 

Dei Tos AP, Maestro R, Doglioni C, Piccinin S, Libera DD, Boiocchi M and Fletcher CDM: Tumor suppressor genes and related molecules in leiomyosarcoma. Am J Pathol. 148:1037–1045. 1996.PubMed/NCBI

42 

Hernando E, Charytonowicz E, Dudas ME, Menendez S, Matushansky I, Mills J, Socci ND, Behrendt N, Ma L, Maki RG, et al: The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas. Nat Med. 13:748–753. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Nishio J, Aoki M, Nabeshima K, Iwasaki H and Naito M: Characterization of giant marker and ring chromosomes in a pleomorphic leiomyosarcoma of soft tissue by spectral karyotyping. Oncol Rep 28: 533-538, 2012.
APA
Nishio, J., Aoki, M., Nabeshima, K., Iwasaki, H., & Naito, M. (2012). Characterization of giant marker and ring chromosomes in a pleomorphic leiomyosarcoma of soft tissue by spectral karyotyping. Oncology Reports, 28, 533-538. https://doi.org/10.3892/or.2012.1835
MLA
Nishio, J., Aoki, M., Nabeshima, K., Iwasaki, H., Naito, M."Characterization of giant marker and ring chromosomes in a pleomorphic leiomyosarcoma of soft tissue by spectral karyotyping". Oncology Reports 28.2 (2012): 533-538.
Chicago
Nishio, J., Aoki, M., Nabeshima, K., Iwasaki, H., Naito, M."Characterization of giant marker and ring chromosomes in a pleomorphic leiomyosarcoma of soft tissue by spectral karyotyping". Oncology Reports 28, no. 2 (2012): 533-538. https://doi.org/10.3892/or.2012.1835
Copy and paste a formatted citation
x
Spandidos Publications style
Nishio J, Aoki M, Nabeshima K, Iwasaki H and Naito M: Characterization of giant marker and ring chromosomes in a pleomorphic leiomyosarcoma of soft tissue by spectral karyotyping. Oncol Rep 28: 533-538, 2012.
APA
Nishio, J., Aoki, M., Nabeshima, K., Iwasaki, H., & Naito, M. (2012). Characterization of giant marker and ring chromosomes in a pleomorphic leiomyosarcoma of soft tissue by spectral karyotyping. Oncology Reports, 28, 533-538. https://doi.org/10.3892/or.2012.1835
MLA
Nishio, J., Aoki, M., Nabeshima, K., Iwasaki, H., Naito, M."Characterization of giant marker and ring chromosomes in a pleomorphic leiomyosarcoma of soft tissue by spectral karyotyping". Oncology Reports 28.2 (2012): 533-538.
Chicago
Nishio, J., Aoki, M., Nabeshima, K., Iwasaki, H., Naito, M."Characterization of giant marker and ring chromosomes in a pleomorphic leiomyosarcoma of soft tissue by spectral karyotyping". Oncology Reports 28, no. 2 (2012): 533-538. https://doi.org/10.3892/or.2012.1835
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