Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
August 2012 Volume 28 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August 2012 Volume 28 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Tropism between hepatic and pulmonary metastases in colorectal cancers

  • Authors:
    • Sung-Hyun Kim
    • So-Jung Choi
    • Joon Suk Park
    • Jinseon Lee
    • Yong Beom Cho
    • Min-Woong Kang
    • Woo Yong Lee
    • Yong Soo Choi
    • Hong Kwan Kim
    • Joungho Han
    • Ho-Kyung Chun
    • Jhingook Kim
  • View Affiliations / Copyright

    Affiliations: Samsung Biomedical Research Institute, Sungkyunkwan University, School of Medicine, Seoul 135-710, Republic of Korea, Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul 135-710, Republic of Korea, Department of Surgery, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul 135-710, Republic of Korea, Department of Thoracic and Cardiovascular Surgery, Chungnam National University, Daejeon 305-764, Chungnam, Republic of Korea, Department of Pathology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul 135-710, Republic of Korea
  • Pages: 459-464
    |
    Published online on: May 29, 2012
       https://doi.org/10.3892/or.2012.1837
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In metastatic colorectal cancers, tumor cells are disseminated prior to surgical resection of the primary tumor but remain dormant until proper colonization mechanisms are activated. To identify the colonization mechanisms of the metastatic tumors, we conducted a pairwise comparison between primary colorectal cancers and metastatic tumors (n=12 pairs), including six hepatic pairs and six pulmonary pairs. The mRNA levels of 224 genes previously reported to be associated with metastasis, cytokines and angiogenesis were quantitatively determined by PCR arrays. Among them, 27 genes were duplicated or triplicated to show consistent expression. Unsupervised hierarchical clustering of the Ct values of metastasis-related genes revealed that liver metastases were indistinguishable from primary colorectal cancers (n=5/6), whereas lung metastases were highly diversified from one another and from the primary tumors (n=6/6). Cytokines and receptor gene expression array data also confirmed the divergence of pulmonary metastases from primary colorectal cancers (n=6/6). Heat map analyses of ΔCt values of the metastasis-related genes identified a 17-gene tropism signature that was sufficient not only to distinguish liver and the lung metastases, but also reconstituted the clustering of primary tumors with the hepatic metastases (n=17/18). In this pilot experiment, pulmonary metastases were significantly diverged from hepatic metastases that were indistinguishable from primary colorectal cancers. Further genomic and clinical studies are in progress to evaluate the potential of the tropism signature as a therapeutic target to inhibit the colonization of metastatic colorectal cancers.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Nguyen DX, Paula DB and Massagué J: Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer. 9:274–284. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Fidler IJ: Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. Cancer Res. 50:6130–6138. 1990.PubMed/NCBI

3 

Talmadge JE and Fidler IJ: AACR centennial series: the biology of cancer metastasis: historical perspective. Cancer Res. 70:5649–5669. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Hanahan D and Weinberg RA: Hallmarks of cancer: the next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Pantel K and Brakenhoff RH: Dissecting the metastatic cascade. Nat Rev Cancer. 4:448–456. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Braun S, Vogl FD, Naume B, et al: A pooled analysis of bone marrow micrometastasis in breast cancer. N Engl J Med. 353:793–802. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Hüsemann Y, Geigl JB, Schubert F, et al: Systemic spread is an early step in breast cancer. Cancer Cell. 13:58–68. 2008.

8 

Lin H, Balic M, Zheng S, Datar R and Cote RJ: Disseminated and circulating tumor cells: Role in effective cancer management. Crit Rev Oncol Hematol. 77:1–11. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Flatmark K, Borgen E, Nesland JM, et al: Disseminated tumor cells as a prognostic biomarker in colorectal cancer. Br J Cancer. 104:1434–1439. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Sugimura H, Nichols FC, Yang P, et al: Survival after recurrent non small-cell lung cancer after complete pulmonary resection. Ann Thorac Surg. 83:409–418. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Feld R, Rubinstein LV and Weisenberger TH: Sites of recurrence in resected stage I non-small-cell lung cancer: a guide for future studies. J Clin Oncol. 2:1352–1358. 1984.PubMed/NCBI

12 

Gutt R, Liauw SL and Weichselbaum RR: Adjuvant radiotherapy for resected pancreatic cancer: a lack of benefit or a lack of adequate trials? Nat Clin Pract Gastroenterol Hepatol. 6:38–46. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Schabel FM Jr: Rationale for adjuvant chemotherapy. Cancer. 39:2875–2882. 1977. View Article : Google Scholar : PubMed/NCBI

14 

Visbal AL, Leighl NB, Feld R and Shepherd FA: Adjuvant chemotherapy for early-stage non-small cell lung cancer. Chest. 128:2933–2943. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Navin N, Kendall J, Troge J, et al: Tumour evolution inferred by single-cell sequencing. Nature. 472:90–94. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Campbell PJ, Yachida S, Mudie LJ, et al: The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature. 467:1109–1113. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Greaves M and Maley CC: Clonal evolution in cancer. Nature. 481:306–313. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Malanchi I, Santamaria-Martinez A, Susanto E, et al: Interactions between cancer stem cells and their niche govern metastatic colonization. Nature. 481:85–89. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Navab R, Strumpf D, Bandarchi B, et al: Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer. Proc Natl Acad Sci USA. 108:7160–7165. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Mink SR, Vashistha S, Zhang W, et al: Cancer-associated fibroblasts derived from EGFR-TKI-resistant tumors reverse EGFR pathway inhibition by EGFR-TKIs. Mol Cancer Res. 8:809–820. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Wang W, Li Q, Yamada T, et al: Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors. Clin Cancer Res. 15:6630–6638. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Serebriiskii I, Castelló-Cros R, Lamb A, Golemis EA and Cukierman E: Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells. Matrix Biol. 27:573–585. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Wilmanns C, Fan D, O’Brian CA, Bucana CD and Fidler IJ: Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5-fluorouracil. Int J Cancer. 52:98–104. 1992. View Article : Google Scholar

24 

Kim S-H, Choi S, Cho YB, et al: Differential gene expression during colon-to-lung metastasis. Oncol Rep. 25:629–36. 2011.PubMed/NCBI

25 

Gilson N, Honoré O, Detry O, et al: Surgical management of hepatic metastases of colorectal origin. Acta Gastroenterol Belg. 72:321–326. 2009.PubMed/NCBI

26 

Kjeldsen BJ, Kronborg O, Fenger C and Jorgensen OD: The pattern of recurrent colorectal cancer in a prospective randomized study and the characteristics of diagnostic tests. Int J Colorectal Dis. 12:329–334. 1997. View Article : Google Scholar : PubMed/NCBI

27 

Fidler IJ and Kripke ML: Genomic analysis of primary tumors does not address the prevalence of metastatic cells in the population. Nat Genet. 34:232003. View Article : Google Scholar : PubMed/NCBI

28 

Jones S, Chen WD, Parmigiani G, et al: Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci USA. 105:4283–4288. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Fidler IJ: The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited. Nat Rev Cancer. 3:453–458. 2003.

30 

Psaila B and Lyden D: The metastatic niche: adapting the foreign soil. Nat Rev Cancer. 9:285–293. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Klein CA: Parallel progression of primary tumours and metastases. Nat Rev Cancer. 9:302–312. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Gupta GP and Massague J: Cancer metastasis: building a frame-work. Cell. 127:679–695. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Yamamoto J, Sugihara K, Kosuge T, et al: Pathologic support for limited hepatectomy in the treatment of liver metastasis from colorectal cancer. Ann Surg. 221:74–78. 1995. View Article : Google Scholar : PubMed/NCBI

34 

Park JS, Kim HK, Choi YS, et al: Outcomes after repeated resection for recurrent pulmonary metastases from colorectal cancer. Ann Oncol. 21:1285–1289. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Suriawinata AA and Thung NS: Liver. Histology for Pathologists. Mills SE: 3rd edition. Lippincott Williams & Wilkins; pp. 685–703. 2007

36 

Colby TV, Leslie KO and Yousem SA: Lung. Histology for Pathologists. Mills SE: 3rd edition. Lippincott Williams & Wilkins; pp. 473–504. 2007

37 

Stelzer G, Inger A, Olender T, et al: GeneDecks: paralog hunting and gene-set distillation with GeneCards annotation. OMICS. 13:477–487. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Fidler IJ: Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. Cancer Res. 50:6130–8. 1990.PubMed/NCBI

39 

Kopitz C, Gerg M, Bandapalli OR, et al: Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling. Cancer Res. 67:8615–8623. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Stein U, Walther W, Arlt F, et al: MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Nat Med. 15:59–67. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Lee ES, Son DS, Kim S-H, et al: Prediction of recurrence-free survival in postoperative non-small cell lung cancer patients by using an integrated model of clinical information and gene expression. Clin Cancer Res. 14:7397–7404. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Koh KH, Rhee H, Kang HJ, et al: Differential gene expression profiles of metastases in paired primary and metastatic colorectal carcinomas. Oncology. 75:92–101. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kim S, Choi S, Park JS, Lee J, Cho YB, Kang M, Lee WY, Choi YS, Kim HK, Han J, Han J, et al: Tropism between hepatic and pulmonary metastases in colorectal cancers. Oncol Rep 28: 459-464, 2012.
APA
Kim, S., Choi, S., Park, J.S., Lee, J., Cho, Y.B., Kang, M. ... Kim, J. (2012). Tropism between hepatic and pulmonary metastases in colorectal cancers. Oncology Reports, 28, 459-464. https://doi.org/10.3892/or.2012.1837
MLA
Kim, S., Choi, S., Park, J. S., Lee, J., Cho, Y. B., Kang, M., Lee, W. Y., Choi, Y. S., Kim, H. K., Han, J., Chun, H., Kim, J."Tropism between hepatic and pulmonary metastases in colorectal cancers". Oncology Reports 28.2 (2012): 459-464.
Chicago
Kim, S., Choi, S., Park, J. S., Lee, J., Cho, Y. B., Kang, M., Lee, W. Y., Choi, Y. S., Kim, H. K., Han, J., Chun, H., Kim, J."Tropism between hepatic and pulmonary metastases in colorectal cancers". Oncology Reports 28, no. 2 (2012): 459-464. https://doi.org/10.3892/or.2012.1837
Copy and paste a formatted citation
x
Spandidos Publications style
Kim S, Choi S, Park JS, Lee J, Cho YB, Kang M, Lee WY, Choi YS, Kim HK, Han J, Han J, et al: Tropism between hepatic and pulmonary metastases in colorectal cancers. Oncol Rep 28: 459-464, 2012.
APA
Kim, S., Choi, S., Park, J.S., Lee, J., Cho, Y.B., Kang, M. ... Kim, J. (2012). Tropism between hepatic and pulmonary metastases in colorectal cancers. Oncology Reports, 28, 459-464. https://doi.org/10.3892/or.2012.1837
MLA
Kim, S., Choi, S., Park, J. S., Lee, J., Cho, Y. B., Kang, M., Lee, W. Y., Choi, Y. S., Kim, H. K., Han, J., Chun, H., Kim, J."Tropism between hepatic and pulmonary metastases in colorectal cancers". Oncology Reports 28.2 (2012): 459-464.
Chicago
Kim, S., Choi, S., Park, J. S., Lee, J., Cho, Y. B., Kang, M., Lee, W. Y., Choi, Y. S., Kim, H. K., Han, J., Chun, H., Kim, J."Tropism between hepatic and pulmonary metastases in colorectal cancers". Oncology Reports 28, no. 2 (2012): 459-464. https://doi.org/10.3892/or.2012.1837
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team