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September 2012 Volume 28 Issue 3

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas

  • Authors:
    • Miyuki Nomura
    • Ken-Ichi Shiiba
    • Chiaki Katagiri
    • Isao Kasugai
    • Kouhei Masuda
    • Ikuro Sato
    • Masayuki Sato
    • Yoichiro Kakugawa
    • Eiki Nomura
    • Katsuhisa Hayashi
    • Yoshihiro Nakamura
    • Toshiyuki Nagata
    • Tsunayuki Otsuka
    • Ryuichi Katakura
    • Yoji Yamashita
    • Masami Sato
    • Nobuhiro Tanuma
    • Hiroshi Shima
  • View Affiliations / Copyright

    Affiliations: Division of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Miyagi 981-1293, Japan, Department of General Thoracic Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8580, Japan
  • Pages: 931-936
    |
    Published online on: June 12, 2012
       https://doi.org/10.3892/or.2012.1862
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Abstract

Mitogen-activated protein kinase phosphatase 5 (MKP-5)/DUSP10 acts as a phosphatase of stress-activated kinases (JNK and p38), but its activity towards ERK has not been demonstrated. In the present study we observed that MKP-5 interacts with ERK, retains it in the cytoplasm, suppresses its activation and downregulates ERK-dependent transcription. These data suggested a novel MKP-5 function as a scaffold protein for the ERK pathway. We analyzed MKP-5 gene expression in several tumors, and found that it is frequently upregulated in colorectal but not in lung and breast cancer, suggesting its association with the malignant phenotype of colon cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Nomura M, Shiiba K, Katagiri C, Kasugai I, Masuda K, Sato I, Sato M, Kakugawa Y, Nomura E, Hayashi K, Hayashi K, et al: Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas. Oncol Rep 28: 931-936, 2012.
APA
Nomura, M., Shiiba, K., Katagiri, C., Kasugai, I., Masuda, K., Sato, I. ... Shima, H. (2012). Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas. Oncology Reports, 28, 931-936. https://doi.org/10.3892/or.2012.1862
MLA
Nomura, M., Shiiba, K., Katagiri, C., Kasugai, I., Masuda, K., Sato, I., Sato, M., Kakugawa, Y., Nomura, E., Hayashi, K., Nakamura, Y., Nagata, T., Otsuka, T., Katakura, R., Yamashita, Y., Sato, M., Tanuma, N., Shima, H."Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas". Oncology Reports 28.3 (2012): 931-936.
Chicago
Nomura, M., Shiiba, K., Katagiri, C., Kasugai, I., Masuda, K., Sato, I., Sato, M., Kakugawa, Y., Nomura, E., Hayashi, K., Nakamura, Y., Nagata, T., Otsuka, T., Katakura, R., Yamashita, Y., Sato, M., Tanuma, N., Shima, H."Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas". Oncology Reports 28, no. 3 (2012): 931-936. https://doi.org/10.3892/or.2012.1862
Copy and paste a formatted citation
x
Spandidos Publications style
Nomura M, Shiiba K, Katagiri C, Kasugai I, Masuda K, Sato I, Sato M, Kakugawa Y, Nomura E, Hayashi K, Hayashi K, et al: Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas. Oncol Rep 28: 931-936, 2012.
APA
Nomura, M., Shiiba, K., Katagiri, C., Kasugai, I., Masuda, K., Sato, I. ... Shima, H. (2012). Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas. Oncology Reports, 28, 931-936. https://doi.org/10.3892/or.2012.1862
MLA
Nomura, M., Shiiba, K., Katagiri, C., Kasugai, I., Masuda, K., Sato, I., Sato, M., Kakugawa, Y., Nomura, E., Hayashi, K., Nakamura, Y., Nagata, T., Otsuka, T., Katakura, R., Yamashita, Y., Sato, M., Tanuma, N., Shima, H."Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas". Oncology Reports 28.3 (2012): 931-936.
Chicago
Nomura, M., Shiiba, K., Katagiri, C., Kasugai, I., Masuda, K., Sato, I., Sato, M., Kakugawa, Y., Nomura, E., Hayashi, K., Nakamura, Y., Nagata, T., Otsuka, T., Katakura, R., Yamashita, Y., Sato, M., Tanuma, N., Shima, H."Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas". Oncology Reports 28, no. 3 (2012): 931-936. https://doi.org/10.3892/or.2012.1862
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