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Article

Clinical outcome in diffuse large B-cell lymphoma with hepatitis C virus infection in the rituximab era: A single center experience

  • Authors:
    • Hiroki Nishikawa
    • Mitsuru Tsudo
    • Yukio Osaki
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan, Department of Hematology, Osaka Red Cross Hospital, Osaka, Japan
  • Pages: 835-840
    |
    Published online on: June 25, 2012
       https://doi.org/10.3892/or.2012.1883
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Abstract

Clinical outcome of diffuse large B-cell lymphoma (DLBCL) patients with hepatitis C virus (HCV) infection in the rituximab era remains unclear. The aim of the present study was to compare the clinical outcome, treatment response and hepatotoxicity in DLBCL patients who received rituximab containing immunochemotherapy that had HCV infection and those that did not have HCV infection between January 2004 and October 2011. Of the 272 consecutive histopathologically diagnosed DLBCL patients in our department, a total of 248 were retrospectively analyzed in the present study. There were 28 DLBCL patients with HCV infection (the HCV group) and 220 DLBCL patients without HCV infection (the control group). We compared overall survival (OS), progression-free survival (PFS), treatment response and hepatotoxicity according to HCV infection. In terms of OS (P=0.525) and PFS (P=0.759), there were no significant differences between the HCV group and the control group. Objective response rates were 92.9% (26/28) in the HCV group and 95.9% (211/220) in the control group (P=0.619). In the HCV group, seven patients (25.0%) developed hepatotoxicity during immunochemotherapy. In the control group, 35 patients (15.9%) developed hepatotoxicity during chemotherapy. No patient required discontinuation of immunochemotherapy owing to hepatotoxicity in either group. In terms of hepatotoxicity, there was no significant difference between these two groups (P=0.281). In conclusion, our study results suggested that HCV infection might not influence the clinical course in DLBCL patients who receive rituximab-containing immunochemotherapy.
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1 

Mele A, Pulsoni A, Bianco E, Musto P, Szklo A, Sanpaolo MG, Iannitto E, De Renzo A, Martino B, Liso V, et al: Hepatitis C virus and B-cell non-Hodgkin lymphomas: an Italian multicenter case-control study. Blood. 102:996–999. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Ennishi D, Maeda Y, Niitsu N, Kojima M, Izutsu K, Takizawa J, Kusumoto S, Okamoto M, Yokoyama M, Takamatsu Y, et al: Hepatic toxicity and prognosis in hepatitis C virus-infected patients with diffuse large B-cell lymphoma treated with rituximab-containing chemotherapy regimens: a Japanese multicenter analysis. Blood. 116:5119–5125. 2010. View Article : Google Scholar

3 

De Vita S, Sacco C, Sansonno D, Gloghini A, Dammacco F, Crovatto M, Santini G, Dolcetti R, Boiocchi M, Carbone A and Zagonel V: Characterization of overt B-cell lymphomas in patients with hepatitis C virus infection. Blood. 90:776–782. 1997.PubMed/NCBI

4 

Pioltelli P, Zehender G, Monti G, Monteverde A and Galli M: HCV and non-Hodgkin lymphoma. Lancet. 347:624–625. 1996. View Article : Google Scholar : PubMed/NCBI

5 

Matsuo K, Kusano A, Sugumar A, Nakamura S, Tajima K and Mueller NE: Effect of hepatitis C virus infection on the risk of non-Hodgkin’s lymphoma: a meta-analysis of epidemiological studies. Cancer Sci. 95:745–752. 2004.

6 

Gisbert JP, Garcia-Buey L, Pajares JM and Moreno-Otero R: Prevalence of hepatitis C virus infection in B-cell non-Hodgkin’s lymphoma: systematic review and meta-analysis. Gastroenterology. 125:1723–1732. 2003.

7 

Izumi T, Sasaki R, Tsunoda S, Akutsu M, Okamoto H and Miura Y: B cell malignancy and hepatitis C virus infection. Leukemia. 11:516–518. 1997.PubMed/NCBI

8 

Galli M, Pioltelli P, Zehender G, Monti G and Monteverde A: HCV and lymphomagenesis. Lancet. 348:2751996. View Article : Google Scholar : PubMed/NCBI

9 

Hartridge-Lambert SK, Stein EM, Markowitz AJ and Portlock CS: Hepatitis C and non-Hodgkin lymphoma: the clinical perspective. Hepatology. 55:634–641. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Kawatani T, Suou T, Tajima F, Ishiga K, Omura H, Endo A, Ohmura H, Ikuta Y, Idobe Y and Kawasaki H: Incidence of hepatitis virus infection and severe liver dysfunction in patients receiving chemotherapy for hematologic malignancies. Eur J Haematol. 67:45–50. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Zuckerman E, Zuckerman T, Douer D, Qian D and Levine AM: Liver dysfunction in patients infected with hepatitis C virus undergoing chemotherapy for hematologic malignancies. Cancer. 83:1224–1230. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Besson C, Canioni D, Lepage E, Pol S, Morel P, Lederlin P, van Hoof A, Tilly H, Gaulard P, Coiffier B, et al: Groupe d’Etude des Lymphomes de l’Adulte Programs: Characteristics and outcome of diffuse large B-cell lymphoma in hepatitis C virus-positive patients in LNH 93 and LNH 98 Groupe d’Etude des Lymphomes de l’Adulte programs. J Clin Oncol. 24:953–960. 2006.

13 

Arcaini L, Merli M, Passamonti F, Bruno R, Brusamolino E, Sacchi P, Rattotti S, Orlandi E, Rumi E, et al: Impact of treatment-related liver toxicity on the outcome of HCV-positive non-Hodgkin’s lymphomas. Am J Hematol. 85:46–50. 2009.PubMed/NCBI

14 

Tobinai K and Hotta T: Clinical trials for malignant lymphoma in Japan. Jpn J Clin Oncol. 34:369–378. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Lake-Bakaar G, Dustin L, McKeating J, Newton K, Freeman V and Frost SD: Hepatitis C virus and alanine aminotransferase kinetics following B-lymphocyte depletion with rituximab: evidence for a significant role of humoral immunity in the control of viremia in chronic HCV liver disease. Blood. 109:845–846. 2007. View Article : Google Scholar

16 

Tsutsumi Y, Kanamori H, Mori A, Tanaka J, Asaka M, Imamura M and Masauzi N: Reactivation of hepatitis B virus with rituximab. Expert Opin Drug Saf. 4:599–608. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Dai MS, Chao TY, Kao WY, Shyu RY and Liu TM: Delayed hepatitis B virus reactivation after cessation of preemptive lamivudine in lymphoma patients treated with rituximab plus CHOP. Ann Hematol. 83:769–774. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Niitsu N, Hagiwara Y, Tanae K, Kohri M and Takahashi N: Prospective analysis of hepatitis B virus reactivation in patients with diffuse large B-cell lymphoma after rituximab combination chemotherapy. J Clin Oncol. 28:5097–5100. 2010. View Article : Google Scholar : PubMed/NCBI

19 

De Renzo A, Perna F, Persico M, Notaro R, Mainolfi C, de Sio I, Ciancia G, Picardi M, Del Vecchio L, Pane F and Rotoli B: Excellent prognosis and prevalence of HCV infection of primary hepatic and splenic non-Hodgkin’s lymphoma. Eur J Haematol. 81:51–57. 2008.PubMed/NCBI

20 

Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA and Bloomfield CD: World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol. 17:3835–3849. 1999.

21 

Ohno O, Mizokami M, Wu RR, Saleh MG, Ohba K, Orito E, Mukaide M, Williams R and Lau JY: New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a. J Clin Microbiol. 35:201–207. 1997.PubMed/NCBI

22 

Carbone PP, Kaplan HS, Musshoff K, Smithers DW and Tubiana M: Report of the Committee on Hodgkin’s Disease Staging Classification. Cancer Res. 31:1860–1861. 1971.

23 

Cheson BD, Pfistner B, Juweid ME, Gascoyne RD, Specht L, Horning SJ, Coiffier B, Fisher RI, Hagenbeek A, Zucca E, Rosen ST, Stroobants S, Lister TA, Hoppe RT, Dreyling M, Tobinai K, Vose JM, Connors JM, Federico M and Diehl V: International Harmonization Project on Lymphoma: revised response criteria for malignant lymphoma. J Clin Oncol. 25:579–586. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Labarga P, Soriano V, Vispo ME, Pinilla J, Martin-Carbonero L, Castellares C, Casado R, Maida I, Garcia-Gasco P and Barreiro P: Hepatotoxicity of antiretroviral drugs is reduced after successful treatment of chronic hepatitis C in HIV-infected patients. J Infect Dis. 196:670–676. 2007. View Article : Google Scholar : PubMed/NCBI

25 

[No authors listed]. A predictive model for aggressive non-Hodgkin’s lymphoma. The International Non-Hodgkin’s Lymphoma Prognostic Factors Project. N Engl J Med. 329:987–994. 1993.

26 

Visco C, Arcaini L, Brusamolino E, Burcheri S, Ambrosetti A, Merli M, Bonoldi E, Chilosi M, Viglio A, Lazzarino M, et al: Distinctive natural history in hepatitis C virus positive diffuse large B-cell lymphoma: analysis of 156 patients from northern Italy. Ann Oncol. 17:1434–1440. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Yoshida H, Shiratori Y, Moriyama M, Arakawa Y, Ide T, Sata M, Inoue O, Yano M, Tanaka M, Fujiyama S, et al: Interferon therapy reduces the risk for hepatocellular carcinoma: national surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. IHIT Study Group. Ann Intern Med. 131:174–181. 1999. View Article : Google Scholar

28 

Nishiguchi S, Shiomi S, Nakatani S, Takeda T, Fukuda K, Tamori A, Habu D and Tanaka T: Prevention of hepatocellular carcinoma in patients with chronic active hepatitis C and cirrhosis. Lancet. 357:196–197. 2001. View Article : Google Scholar : PubMed/NCBI

29 

La Mura V, De Renzo A, Perna F, D’Agostino D, Masarone M, Romano M, Bruno S, Torella R and Persico M: Antiviral therapy after complete response to chemotherapy could be efficacious in HCV-positive non-Hodgkin’s lymphoma. J Hepatol. 49:557–563. 2008.PubMed/NCBI

30 

Pellicelli AM, Marignani M, Zoli V, Romano M, Morrone A, Nosotti L, Barbaro G, Picardi A, Gentilucci UV, Remotti D, et al: Hepatitis C virus-related B cell subtypes in non Hodgkin’s lymphoma. World J Hepatol. 3:278–284. 2011.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Nishikawa H, Tsudo M and Osaki Y: Clinical outcome in diffuse large B-cell lymphoma with hepatitis C virus infection in the rituximab era: A single center experience. Oncol Rep 28: 835-840, 2012.
APA
Nishikawa, H., Tsudo, M., & Osaki, Y. (2012). Clinical outcome in diffuse large B-cell lymphoma with hepatitis C virus infection in the rituximab era: A single center experience. Oncology Reports, 28, 835-840. https://doi.org/10.3892/or.2012.1883
MLA
Nishikawa, H., Tsudo, M., Osaki, Y."Clinical outcome in diffuse large B-cell lymphoma with hepatitis C virus infection in the rituximab era: A single center experience". Oncology Reports 28.3 (2012): 835-840.
Chicago
Nishikawa, H., Tsudo, M., Osaki, Y."Clinical outcome in diffuse large B-cell lymphoma with hepatitis C virus infection in the rituximab era: A single center experience". Oncology Reports 28, no. 3 (2012): 835-840. https://doi.org/10.3892/or.2012.1883
Copy and paste a formatted citation
x
Spandidos Publications style
Nishikawa H, Tsudo M and Osaki Y: Clinical outcome in diffuse large B-cell lymphoma with hepatitis C virus infection in the rituximab era: A single center experience. Oncol Rep 28: 835-840, 2012.
APA
Nishikawa, H., Tsudo, M., & Osaki, Y. (2012). Clinical outcome in diffuse large B-cell lymphoma with hepatitis C virus infection in the rituximab era: A single center experience. Oncology Reports, 28, 835-840. https://doi.org/10.3892/or.2012.1883
MLA
Nishikawa, H., Tsudo, M., Osaki, Y."Clinical outcome in diffuse large B-cell lymphoma with hepatitis C virus infection in the rituximab era: A single center experience". Oncology Reports 28.3 (2012): 835-840.
Chicago
Nishikawa, H., Tsudo, M., Osaki, Y."Clinical outcome in diffuse large B-cell lymphoma with hepatitis C virus infection in the rituximab era: A single center experience". Oncology Reports 28, no. 3 (2012): 835-840. https://doi.org/10.3892/or.2012.1883
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