Prediction of invasion depth for submucosal differentiated gastric cancer by magnifying endoscopy with narrow-band imaging

Kobara,Hideki; Mori,Hirohito; Fujihara,Shintaro; Kobayashi,Mitsuyoshi; Nishiyama,Noriko; Nomura,Takako; Kato,Kiyohito; Ishihara,Shinichi; Morito,Toshiaki; Mizobuchi,Koichi; Iwama,Hisakazu; Masaki,Tsutomu

doi:10.3892/or.2012.1889

September 2012 Volume 28 Issue 3

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September 2012 Volume 28 Issue 3

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Article

Prediction of invasion depth for submucosal differentiated gastric cancer by magnifying endoscopy with narrow-band imaging

Authors:
- Hideki Kobara
- Hirohito Mori
- Shintaro Fujihara
- Mitsuyoshi Kobayashi
- Noriko Nishiyama
- Takako Nomura
- Kiyohito Kato
- Shinichi Ishihara
- Toshiaki Morito
- Koichi Mizobuchi
- Hisakazu Iwama
- Tsutomu Masaki
View Affiliations / Copyright

Affiliations: Department of Gastroenterology and Neurology, Kagawa Medical University School of Medicine, Kagawa 761-0793, Japan, Department of Gastroenterology, Kagawa Rosai Hospital, Kagawa 763-8502, Japan, Department of Pathology, Kagawa Rosai Hospital, Kagawa 763-8502, Japan, Life Science Research Center, Kagawa Medical University School of Medicine, Kagawa 761-0793, Japan
Pages: 841-847
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Published online on: June 26, 2012

https://doi.org/10.3892/or.2012.1889
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Abstract

The usefulness of determining gastric cancer invasion depth by magnifying endoscopy with narrow-band imaging (NBI-ME) has not been established. The objective of our study was to retrospectively compare NBI-ME images of differentiated submucosal (SM) 1 cancer with those of SM2 to identify the indicators of invasion depth for SM2 gastric cancer. Fifteen patients with SM1 differentiated gastric cancer and 20 with SM2 removed by endoscopic submucosal resection (ESD) were included. NBI-ME images matching the invasion depth of pathological specimens were examined to define the following three findings as diagnostic indicators of SM2: non-structure, scattery vessels and multi-caliber vessels. The relationship between indicators and invasion depth and between indicator score and invasion depth was examined in 27 patients (SM1/SM2: 11/16) with depressed-type gastric cancer (D-GC) and in 8 (SM1/SM2: 4/4) with protruding-type gastric cancer (P-GC). Diagnostic accuracy for invasion depth determined by four endoscopists using regular endoscopic images was compared with that determined by the same endoscopists using NBI-ME. In D-GC, all three indicators were significantly more frequent in SM2 than in SM1 (p<0.05). All D-GC with ≥2 points were SM2, demonstrating a significant difference in score distribution between SM1 and SM2 (p<0.05). In D-GC, diagnostic accuracy by NBI-ME was higher than that by regular endoscopy by all 4 endoscopists (p<0.05). NBI-ME findings of non-structure, scattery vessels and multi-caliber vessels can possibly serve as indicators of SM2 invasion in differentiated D-GC. Scoring of the three indicators was significant.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Prediction of invasion depth for submucosal differentiated gastric cancer by magnifying endoscopy with narrow-band imaging

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