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Increased E-selectin in hepatic ischemia-reperfusion injury mediates liver metastasis of pancreatic cancer

  • Authors:
    • Katsuhiro Yoshimoto
    • Hidehiro Tajima
    • Tetsuo Ohta
    • Koichi Okamoto
    • Seisho Sakai
    • Jun Kinoshita
    • Hiroyuki Furukawa
    • Isamu Makino
    • Hironori Hayashi
    • Keishi Nakamura
    • Katsunobu Oyama
    • Masafumi Inokuchi
    • Hisatoshi Nakagawara
    • Hiroshi Itoh
    • Hideto Fujita
    • Hiroyuki Takamura
    • Itasu Ninomiya
    • Hirohisa Kitagawa
    • Sachio Fushida
    • Takashi Fujimura
    • Tomohiko Wakayama
    • Shoichi Iseki
    • Koichi Shimizu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterologic Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan, Department of Histology and Embryology, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan, Department of Surgery, Toyama Prefectural Central Hospital, Toyama, Japan
    Copyright: © Yoshimoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 791-796
    |
    Published online on: July 3, 2012
       https://doi.org/10.3892/or.2012.1896
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Abstract

Several recent studies have reported that selectins are produced during ischemia-reperfusion injury, and that selectin ligands play an important role in cell binding to the endothelium and in liver metastasis. Portal clamping during pancreaticoduodenectomy with vessel resection for pancreatic head cancer causes hepatic ischemia-reperfusion injury, which might promote liver metastasis. We investigated the liver colonization of pancreatic cancer cells under hepatic ischemia-reperfusion and examined the involvement of E-selectin and its ligands. A human pancreatic cancer cell line (Capan-1) was injected into the spleen of mice after hepatic ischemia-reperfusion (I/R group). In addition, to investigate the effect of an anti-E-selectin antibody on liver colonization in the IR group, mice received an intraperitoneal injection of the anti-E-selectin antibody following hepatic ischemia-reperfusion and tumor inoculation (IR+Ab group). Four weeks later, mice were sacrificed and the number of tumor nodules on the liver was compared to mice without hepatic ischemia-reperfusion (control group). The incidence of liver metastasis in the I/R group was significantly higher (16 of 20, 80%) than that in the control group (6 of 20, 30%) (P<0.01). Moreover, mice in the I/R group had significantly more tumor nodules compared to those in the control group (median, 9.9 vs. 2.7 nodules) (P<0.01). In the I/R+Ab group, only 2 of 5 (40%) mice developed liver metastases. RT-PCR and southern blotting of the liver extracts showed that the expression of IL-1 and E-selectin mRNA after hepatic ischemia-reperfusion was significantly higher than the basal levels. Hepatic ischemia-reperfusion increases liver metastases and E-selectin expression in pancreatic cancer. These results suggest that E-selectin produced due to hepatic ischemia-reperfusion is involved in liver metastasis.
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1 

International Agency for Research on Cancer, World Health Organization. Globocan 2008. World Health Organization. Web site. http://globocan.iarc.fr/. Accessed February 17, 2012

2 

Evans DB, Abbruzzese JL and Willett CG: Cancer of the pancreas. Cancer, Principles and Practice of Oncology. De Vita VT, Hellman S and Rosenberg SA: 6th edition. Lippincott Williams and Wilkins; Philadelphia: pp. 1126–1161. 2001

3 

Lasly LA: Selectins: interpreters of cell-specific carbohydrate information during inflammation. Science. 258:964–969. 1992. View Article : Google Scholar : PubMed/NCBI

4 

Sass PM: The involvement of selectins in cell adhesion, tumor progression, and metastasis. Cancer Invest. 16:322–328. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Lauri D, Needham L, Martin-Padura I and Dejana E: Tumor cell adhesion to endothelial cells: endothelial leukocyte adhesion molecule-1 as an inducible adhesive receptor specific for colon carcinoma cells. J Natl Cancer Inst. 83:1321–1324. 1991. View Article : Google Scholar

6 

Takada A, Ohmori K, Takahashi N, et al: Adhesion of human cancer cells to vascular endothelium mediated by a carbohydrate antigen, sialyl Lewis A. Biochem Biophys Res Commun. 179:713–719. 1991. View Article : Google Scholar : PubMed/NCBI

7 

Dejana E, Martin-Padura I, Lauri D, et al: Endothelial leukocyte adhesion molecule-1-dependent adhesion of colon carcinoma cells to vascular endothelium is inhibited by an antibody to Lewis fucosylated type I carbohydrate chain. Lab Invest. 66:324–330. 1992.

8 

Tozeren A, Kleinman HK, Gfant DS, Morales D, Mercurio AM and Byers SW: E-selectin-mediated dynamic interactions of breast- and colon-cancer cells with endothelial-cell monolayers. Int J Cancer. 60:426–431. 1995. View Article : Google Scholar : PubMed/NCBI

9 

Takada A, Ohmori K, Yoneda T, et al: Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium. Cancer Res. 53:354–361. 1993.PubMed/NCBI

10 

Walz G, Aruffo A, Kolanus W, Bevilaqua M and Seed B: Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells. Science. 250:1132–1135. 1990. View Article : Google Scholar : PubMed/NCBI

11 

Majuri ML, Mattila P and Renkonen R: Recombinant E-selectin-protein mediates tumor cell adhesion via sialyl-Lea and sialyl-Lx. Biochem Biohys Res Commun. 182:1376–1382. 1992. View Article : Google Scholar : PubMed/NCBI

12 

Foxall C, Watson SR, Dowbenko D, et al: The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl Lewis(x) oligosaccharide. J Cell Biol. 117:895–902. 1992. View Article : Google Scholar : PubMed/NCBI

13 

Izumi Y, Taniuchi Y, Tsuji T, et al: Characterization of human colon carcinoma variant cells selected for sialyl Lex carbohydrate antigen: liver colonization and adhesion to vascular endothelial cells. Exp Cell Res. 216:215–221. 1995. View Article : Google Scholar

14 

Srinivas U, Påhlsson P and Lundblad A: E-selectin: sialyl Lewis a dependent adhesion of colon cancer cells, is inhibited differently by antibodies against E-selectin ligands. Scand J Immunol. 44:197–203. 1996. View Article : Google Scholar : PubMed/NCBI

15 

Iwai K, Ishikura H, Kaji M, et al: Importance of E-selectin (ELAM-1) and sialyl Lewis(a) in the adhesion of pancreatic carcinoma cells to activated endothelium. Int J Cancer. 54:972–977. 1993. View Article : Google Scholar : PubMed/NCBI

16 

Kimura N, Muraoka R, Horiuchi T, et al: Intermittent hepatic pedicle clamping reduces liver and lung injury. J Surg Res. 78:11–17. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Uchinami M, Muraoka R, Horiuchi T, et al: Effect of intermittent hepatic pedicle clamping on free radical generation in the rat liver. Surgery. 124:49–56. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Horiuchi T, Muraoka R, Tabo T, Uchinami M, Kimura N and Tanigawa N: Optimal cycles of hepatic ischemia and reperfusion for intermittent pedicle clamping during liver surgery. Arch Surg. 130:754–758. 1995. View Article : Google Scholar : PubMed/NCBI

19 

Colletti LM, Remick DG, Burtch GD, Kunkel SL, Strieter RM and Campbell DA Jr: Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat. J Clin Invest. 85:1936–1943. 1990. View Article : Google Scholar : PubMed/NCBI

20 

Doi K, Horiuchi T, Uchinami M, et al: Hepatic ischemia-reperfusion promotes liver metastasis of colon cancer. J Surg Res. 105:243–247. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Ohta T, Futabgami F, Tajima H, et al: Inhibitory effect of a serine protease inhibitor, FOY-305 on the invasion and metastasis of human pancreatic cancer. Int J Oncol. 11:813–817. 1997.PubMed/NCBI

22 

Lomedico PT, Gubler U, Hellmann CP, et al: Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature. 312:458–462. 1984. View Article : Google Scholar : PubMed/NCBI

23 

Fransen L, Müller R, Marmenout A, et al: Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression. Nucleic Acids Res. 13:4417–4429. 1985. View Article : Google Scholar : PubMed/NCBI

24 

Sabath DE, Broome HE and Prystowsky MB: Glyceraldehyde-3-phosphate dehydrogenase mRNA is a major interleukin 2-induced transcript in a cloned T-helper lymphocyte. Gene. 91:185–191. 1990. View Article : Google Scholar : PubMed/NCBI

25 

Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:156–159. 1987. View Article : Google Scholar : PubMed/NCBI

26 

Southern EM: Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 98:503–517. 1975. View Article : Google Scholar : PubMed/NCBI

27 

Brodt P: Adhesion receptors and proteolytic mechanisms in cancer invasion and metastasis. Cell Adhesion and Invasion in Cancer Metastasis. Brodt P: Landes, Austin; pp. 167–242. 1996

28 

Radinsky R and Fidler IJ: Regulation of tumor cell growth at organ-specific metastases. In Vivo. 6:325–331. 1992.PubMed/NCBI

29 

Zetter BR: The cellular basis of site-specific tumor metastasis. N Eng J Med. 322:605–612. 1990. View Article : Google Scholar : PubMed/NCBI

30 

Zetter BR: Adhesion molecules in tumor metastasis. Semin Cancer Biol. 4:219–229. 1993.PubMed/NCBI

31 

Rice GE and Bevilacqua MP: An inducible endothelial cell surface glycoprotein mediates melanoma adhesion. Science. 246:1303–1306. 1989. View Article : Google Scholar : PubMed/NCBI

32 

Bevilacqua MP and Nelson RM: Selectins. J Clin Invest. 91:379–387. 1993. View Article : Google Scholar : PubMed/NCBI

33 

Bevilacqua MP, Stengelin S, Gimbrone MA Jr and Seed B: Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science. 243:1160–1165. 1989. View Article : Google Scholar

34 

Phillips ML, Nudelman E and Gaeta FC: ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex. Science. 250:1130–1132. 1990. View Article : Google Scholar : PubMed/NCBI

35 

Zhang K, Baeckström D and Hansson GC: A secreted mucin carrying sialyl-Lewis a from colon carcinoma cells binds to E-selectin and inhibits HL-60 cell adhesion. Int J Cancer. 59:823–829. 1994. View Article : Google Scholar : PubMed/NCBI

36 

Brodt P, Fallavollita L, Bresalier RS, Meterissian S, Norton CR and Wolitzky BA: Liver endothelial E-selectin mediates carcinoma cell adhesion and promotes liver metastasis. Int J Cancer. 71:612–619. 1997. View Article : Google Scholar : PubMed/NCBI

37 

Khatib AM, Kontogiannea M, Fallavollita L, Jamison B, Meterissian S and Brodt P: Rapid induction of cytokine and E-selectin expression in the liver in response to metastatic tumor cells. Cancer Res. 59:1356–1361. 1999.PubMed/NCBI

38 

Uotani H, Yamashita I, Nagata T, Kishimoto H, Kashii Y and Tsukada K: Induction of E-selectin after partial hepatectomy promotes metastases to liver in mice. J Surg Res. 96:197–203. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Burke J, Zibari GB, Brown MF, et al: Hepatic ischemia-reperfusion injury causes E-selectin upregulation. Transplant Proc. 30:2321–2323. 1998. View Article : Google Scholar : PubMed/NCBI

40 

Pringle JH: Notes on the arrest of hepatic hemorrhage due to trauma. Ann Surg. 48:541–549. 1908. View Article : Google Scholar : PubMed/NCBI

41 

Colletti LM, Kunkel SL and Walz A: The role of cytokine networks in the local liver injury following hepatic ischemia/reperfusion in the rat. Hepatology. 23:506–514. 1996. View Article : Google Scholar : PubMed/NCBI

42 

Brown MF, Zibari G, Burney D, Granger DN and McDonald JC: Hepatic ischemia/reperfusion affects leukocyte rolling and velocity. Clin Transplant. 11:511–515. 1997.PubMed/NCBI

43 

Hanisch FG, Hanski C and Hasegawa A: Sialyl Lewis(x) antigen as defined by monoclonal antibody AM-3 is a marker of dysplasia in the colonic adenoma-carcinoma sequence. Cancer Res. 52:3138–3144. 1992.

44 

Nakamori S, Kameyama M and Imaoka S: Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study. Cancer Res. 53:3632–3637. 1993.

45 

Kaji M, Ishikura H, Kishimoto T, et al: E-selectin expression induced by pancreas-carcinoma-derived interleukin-1 alpha results in enhanced adhesion of pancreas-carcinoma cells to endothelial cells. Int J Cancer. 60:712–717. 1995. View Article : Google Scholar

46 

Kishimoto T, Ishikura H, Kimura C, Takahashi T, Kato H and Yoshiki T: Phenotypes correlating to metastatic properties of pancreas adenocarcinoma in vivo: the importance of surface sialyl Lewis(a) antigen. Int J Cancer. 69:290–294. 1996. View Article : Google Scholar : PubMed/NCBI

47 

Yoshida M, Horiuchi T, Uchinami M, et al: Intermittent hepatic ischemia-reperfusion minimizes liver metastasis in rats. J Surg Res. 111:255–260. 2003. View Article : Google Scholar : PubMed/NCBI

48 

Takeshita M, Tani T, Harada S, et al: Role of transcription factors in small intestinal ischemia-reperfusion injury and tolerance induced by ischemic preconditioning. Transplant Proc. 42:3406–3413. 2010. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yoshimoto K, Tajima H, Ohta T, Okamoto K, Sakai S, Kinoshita J, Furukawa H, Makino I, Hayashi H, Nakamura K, Nakamura K, et al: Increased E-selectin in hepatic ischemia-reperfusion injury mediates liver metastasis of pancreatic cancer. Oncol Rep 28: 791-796, 2012.
APA
Yoshimoto, K., Tajima, H., Ohta, T., Okamoto, K., Sakai, S., Kinoshita, J. ... Shimizu, K. (2012). Increased E-selectin in hepatic ischemia-reperfusion injury mediates liver metastasis of pancreatic cancer. Oncology Reports, 28, 791-796. https://doi.org/10.3892/or.2012.1896
MLA
Yoshimoto, K., Tajima, H., Ohta, T., Okamoto, K., Sakai, S., Kinoshita, J., Furukawa, H., Makino, I., Hayashi, H., Nakamura, K., Oyama, K., Inokuchi, M., Nakagawara, H., Itoh, H., Fujita, H., Takamura, H., Ninomiya, I., Kitagawa, H., Fushida, S., Fujimura, T., Wakayama, T., Iseki, S., Shimizu, K."Increased E-selectin in hepatic ischemia-reperfusion injury mediates liver metastasis of pancreatic cancer". Oncology Reports 28.3 (2012): 791-796.
Chicago
Yoshimoto, K., Tajima, H., Ohta, T., Okamoto, K., Sakai, S., Kinoshita, J., Furukawa, H., Makino, I., Hayashi, H., Nakamura, K., Oyama, K., Inokuchi, M., Nakagawara, H., Itoh, H., Fujita, H., Takamura, H., Ninomiya, I., Kitagawa, H., Fushida, S., Fujimura, T., Wakayama, T., Iseki, S., Shimizu, K."Increased E-selectin in hepatic ischemia-reperfusion injury mediates liver metastasis of pancreatic cancer". Oncology Reports 28, no. 3 (2012): 791-796. https://doi.org/10.3892/or.2012.1896
Copy and paste a formatted citation
x
Spandidos Publications style
Yoshimoto K, Tajima H, Ohta T, Okamoto K, Sakai S, Kinoshita J, Furukawa H, Makino I, Hayashi H, Nakamura K, Nakamura K, et al: Increased E-selectin in hepatic ischemia-reperfusion injury mediates liver metastasis of pancreatic cancer. Oncol Rep 28: 791-796, 2012.
APA
Yoshimoto, K., Tajima, H., Ohta, T., Okamoto, K., Sakai, S., Kinoshita, J. ... Shimizu, K. (2012). Increased E-selectin in hepatic ischemia-reperfusion injury mediates liver metastasis of pancreatic cancer. Oncology Reports, 28, 791-796. https://doi.org/10.3892/or.2012.1896
MLA
Yoshimoto, K., Tajima, H., Ohta, T., Okamoto, K., Sakai, S., Kinoshita, J., Furukawa, H., Makino, I., Hayashi, H., Nakamura, K., Oyama, K., Inokuchi, M., Nakagawara, H., Itoh, H., Fujita, H., Takamura, H., Ninomiya, I., Kitagawa, H., Fushida, S., Fujimura, T., Wakayama, T., Iseki, S., Shimizu, K."Increased E-selectin in hepatic ischemia-reperfusion injury mediates liver metastasis of pancreatic cancer". Oncology Reports 28.3 (2012): 791-796.
Chicago
Yoshimoto, K., Tajima, H., Ohta, T., Okamoto, K., Sakai, S., Kinoshita, J., Furukawa, H., Makino, I., Hayashi, H., Nakamura, K., Oyama, K., Inokuchi, M., Nakagawara, H., Itoh, H., Fujita, H., Takamura, H., Ninomiya, I., Kitagawa, H., Fushida, S., Fujimura, T., Wakayama, T., Iseki, S., Shimizu, K."Increased E-selectin in hepatic ischemia-reperfusion injury mediates liver metastasis of pancreatic cancer". Oncology Reports 28, no. 3 (2012): 791-796. https://doi.org/10.3892/or.2012.1896
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