Breast MALT lymphomas: A clinicopathological and cytogenetic study of 9 cases

Liguori,Giuseppina; Cantile,Monica; Cerrone,Margherita; La Mantia,Elvira; Di Bonito,Maurizio; Zanconati,Fabrizio; Curcio,Maria  Pia; Aquino,Gabriella; La Mura,Anna; Giannatiempo,Rosa; De Chiara,Annarosaria; Lombardi,Angela; Botti,Gerardo; D'Antonio,Antonio; Caraglia,Michele; Franco,Renato

doi:10.3892/or.2012.1942

October 2012 Volume 28 Issue 4

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October 2012 Volume 28 Issue 4

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Article

Breast MALT lymphomas: A clinicopathological and cytogenetic study of 9 cases

Authors:
- Giuseppina Liguori
- Monica Cantile
- Margherita Cerrone
- Elvira La Mantia
- Maurizio Di Bonito
- Fabrizio Zanconati
- Maria Pia Curcio
- Gabriella Aquino
- Anna La Mura
- Rosa Giannatiempo
- Annarosaria De Chiara
- Angela Lombardi
- Gerardo Botti
- Antonio D'Antonio
- Michele Caraglia
- Renato Franco
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Affiliations: Pathology Unit, National Cancer Institute, Pascale Foundation, Naples, Italy, UCO Clinical Surgery, University of Trieste, Trieste, Italy, Pathology Unit, Scafati Hospital, Salerno, Italy, Pathology Unit, Villa Betania Hospital, Naples, Italy, Department of Biochemistry and Biophysics, Second University of Naples, Naples, Italy, Department of Pathological Anatomy and Oncology, A.O.U. ‘San Giovanni di Dio e Ruggi d'Aragona’, Salerno, Italy
Pages: 1211-1216
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Published online on: July 27, 2012

https://doi.org/10.3892/or.2012.1942
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Abstract

Primary breast mucosa-associated lymphoid tissue (MALT) lymphomas are uncommon and restricted diagnostic criteria should be used to exclude breast involvement by systemic lymphomas. The molecular pathogenesis of primary breast MALT lymphomas is not clear because of the rarity of the disease. Generally the molecular studies of MALT lymphoma in extranodal sites have shown the presence of different chromosomal aberrations, mutually exclusive with substantial differences in their frequency relatively to topographic localization. Few cases of breast MALT lymphomas in the literature have been assessed for MALT lymphoma-associated translocations and BCL10 expression, underlying their rarity in primary breast MALT lymphomas. In our study, we analyzed a series of nine cases of primary breast MALT lymphomas. FISH results showed evidence of MALT1 gene rearrangements in four primary breast lymphomas, in particular three cases with t(11;18)(q21;q21) and one case with t(14;18)(q32;q21). In addition, BCL10 gene rearrangement was not observed. There was no evidence of BCL10 gene translocation in any of the neoplasms assessed. Our data indicate that MALT1 gene rearrangements are not rare in primary breast MALT lymphoma in contrast with results of previous series. Finally, t(11;18) has been observed to be significantly associated with high intensity cytoplasmic BCL10 expression underlying cross-talk between MALT1 and BCL10 pathways in the pathogenesis of MALT lymphomas.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Breast MALT lymphomas: A clinicopathological and cytogenetic study of 9 cases

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