The ubiquitin-conjugating enzyme E2-EPF is overexpressed in cervical cancer and associates with tumor growth

  • Authors:
    • Jing Liang
    • Hirotaka Nishi
    • Mei-Lu Bian
    • Chinatsu Higuma
    • Toru Sasaki
    • Hiroe Ito
    • Keiichi Isaka
  • View Affiliations

  • Published online on: August 6, 2012     https://doi.org/10.3892/or.2012.1949
  • Pages: 1519-1525
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Abstract

We found that the ubiquitin-conjugating enzyme E2-EPF mRNA is highly expressed in cervical squamous cancer relative to normal tissues and its expression levels positively correlate with clinical stage. Reduction of E2-EPF protein levels by >80% using shRNA decreases the expression levels of HIF-1α, and the proliferation, invasion and tumorigenicity of SiHa, a cervical squamous cancer cell line. E2-EPF knockdown also increases the chemosensitivity to topoisomerase I inhibitor (topotecan) and II (etoposide and doxorubicin). Our results suggest that E2-EPF is associated with the growth and aggressivity of cervical tumor cells. Targeting the E2-EPF pathway may have potential clinical applications for the treatment of cervical cancer.
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October 2012
Volume 28 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Liang J, Nishi H, Bian M, Higuma C, Sasaki T, Ito H and Isaka K: The ubiquitin-conjugating enzyme E2-EPF is overexpressed in cervical cancer and associates with tumor growth. Oncol Rep 28: 1519-1525, 2012
APA
Liang, J., Nishi, H., Bian, M., Higuma, C., Sasaki, T., Ito, H., & Isaka, K. (2012). The ubiquitin-conjugating enzyme E2-EPF is overexpressed in cervical cancer and associates with tumor growth. Oncology Reports, 28, 1519-1525. https://doi.org/10.3892/or.2012.1949
MLA
Liang, J., Nishi, H., Bian, M., Higuma, C., Sasaki, T., Ito, H., Isaka, K."The ubiquitin-conjugating enzyme E2-EPF is overexpressed in cervical cancer and associates with tumor growth". Oncology Reports 28.4 (2012): 1519-1525.
Chicago
Liang, J., Nishi, H., Bian, M., Higuma, C., Sasaki, T., Ito, H., Isaka, K."The ubiquitin-conjugating enzyme E2-EPF is overexpressed in cervical cancer and associates with tumor growth". Oncology Reports 28, no. 4 (2012): 1519-1525. https://doi.org/10.3892/or.2012.1949