Microwave-induced thermoablation with Amica-probe is a safe and reproducible method to treat solid renal masses: Results from a phase I study

Bartoletti,Riccardo; Meliani,Enrico; Simonato,Alchiede; Gontero,Paolo; Berta,Giovanna; Dalla Palma,Paolo; Leonardi,Elena; Cai,Tommaso; Carmignani,Giorgio

doi:10.3892/or.2012.1950

October 2012 Volume 28 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

October 2012 Volume 28 Issue 4

Full Size Image

Article

Microwave-induced thermoablation with Amica-probe is a safe and reproducible method to treat solid renal masses: Results from a phase I study

Authors:
- Riccardo Bartoletti
- Enrico Meliani
- Alchiede Simonato
- Paolo Gontero
- Giovanna Berta
- Paolo Dalla Palma
- Elena Leonardi
- Tommaso Cai
- Giorgio Carmignani
View Affiliations / Copyright

Affiliations: Department of Urology, Santa Maria Annunziata Hospital, University of Florence, Florence, Italy, Department of Urology, University of Genoa, Genoa, Italy, Department of Urology, University of Turin, Turin, Italy, Department of Pathology, Santa Chiara Hospital, Trento, Italy, Department of Urology, Santa Chiara Hospital, Trento, Italy
Pages: 1243-1248
|
Published online on: August 6, 2012

https://doi.org/10.3892/or.2012.1950
Expand metrics +

Abstract

Microwave thermal ablation (MWTA) could be considered in the future for treating small solid renal masses. The aim of the present study was to determine both the tolerability of the new Amica-probe applicator-induced MWTA used in vivo on patients with solid renal masses and the effects of heating on renal tumors and normal renal parenchyma. Fourteen patients with renal masses eligible for open radical nephrectomy were enrolled in this phase I study. All patients underwent MWTA of renal masses during the open surgery procedure before clamping of renal vascular pedicle. The effects of MWTA on patients' coagulation and tumor/renal vasculature were investigated. The histological effects of MWTA on the tumor and intralesional vital tumor cell skipping were also evaluated. The MWTA-induced lesion diameters were measured to calculate both the overall ablation volume and the lesion sphericity index (SI). The Clavien-Dindo classification was used. In all patients the RENAL score was 9.4 (8-12) and the Charlson comorbidity index was 4.8 (3-7). MWTA-induced lesion size was 44.14 mm (±22.59). Mean SI was 1.08 (±0.2). No significant differences among coagulation clinical parameters were found. No local bleeding after MWTA treatment was reported. According to the Clavien-Dindo classification, there were two grade II perioperative complications due to the tumor extent but not related with the MWTA treatment. No residual vital tumor cells inside the MWTA-induced lesions were found. Telephone interview at 27.4 (±4.2) months mean follow-up did not find any long-term adverse events due to previous MWTA treatment. Amica-Probe applicator-induced MWTA is a safe and reproducible method to treat solid renal masses.

View Figures

View References

1	Novara G and Ficarra V: Is laparoscopic cryoablation a less invasive and effective procedure to treat small renal masses? Eur Urol. 60:444–447. 2011. View Article : Google Scholar : PubMed/NCBI
2	Volpe A, Cadeddu JA, Cestari A, et al: Contemporary management of small renal masses. Eur Urol. 60:501–515. 2011. View Article : Google Scholar : PubMed/NCBI
3	Clements T, Lin YK and Raman JD: Current status of ablative techniques for small renal masses. Expert Rev Anticancer Ther. 11:879–891. 2011. View Article : Google Scholar : PubMed/NCBI
4	Kunkle DA and Uzzo RG: Cryoablation or radiofrequency ablation of the small renal mass: a meta-analysis. Cancer. 113:2671–2680. 2008. View Article : Google Scholar : PubMed/NCBI
5	Zagoria RJ and Childs DD: Update on thermal ablation of renal cell carcinoma: oncologic control, technique comparison, renal function preservation, and new modalities. Curr Urol Rep. 13:63–69. 2012. View Article : Google Scholar : PubMed/NCBI
6	Bhardwaj N, Strickland AD, Ahmad F, Atanesyan L, West K and Lloyd DM: A comparative histological evaluation of the ablations produced by microwave, cryotherapy and radiofrequency in the liver. Pathology. 41:168–172. 2009. View Article : Google Scholar : PubMed/NCBI
7	Itoh K, Suzuki Y, Miuru M, Tsukigi M, Ichiyanagi O and Sasagawa I: Posterior retroperitoneoscopic partial nephrectomy using microwave tissue coagulator for small renal tumors. J Endourol. 16:367–371. 2002. View Article : Google Scholar : PubMed/NCBI
8	Bartoletti R, Cai T, Tosoratti N, et al: In vivo microwave-induced porcine kidney thermoablation: results and perspectives from a pilot study of a new probe. BJU Int. 106:1817–1821. 2010. View Article : Google Scholar : PubMed/NCBI
9	Clark PE, Woodruff RD, Zagoria RJ and Hall MC: Microwave ablation of renal parenchymal tumors before nephrectomy: phase I study. AJR Am J Roentgenol. 188:1212–1214. 2007. View Article : Google Scholar : PubMed/NCBI
10	Kutikov A and Uzzo RG: The R.E.N.A.L. nephrometry score: a comprehensive standardized system for quantitating renal tumor size, location and depth. J Urol. 182:844–853. 2009. View Article : Google Scholar : PubMed/NCBI
11	Charlson ME, Pompei P, Ales KL and MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 40:373–383. 1987. View Article : Google Scholar : PubMed/NCBI
12	Bartoletti R, Cai T, Tinacci G, et al: Transperineal microwave thermoablation in patients with obstructive benign prostatic hyperplasia: a phase I clinical study with a new mini-choked microwave applicator. J Endourol. 22:1509–1517. 2008. View Article : Google Scholar
13	Allison DC and Ridolpho P: Use of a trypan blue assay to measure the deoxyribonucleic acid content and radioactive labeling of viable cells. J Histochem Cytochem. 28:700–703. 1980. View Article : Google Scholar : PubMed/NCBI
14	Hines-Peralta AU, Pirani N, Clegg P, et al: Microwave ablation: results with a 2.45-GHz applicator in ex vivo bovine and in vivo porcine liver. Radiology. 239:94–102. 2006. View Article : Google Scholar : PubMed/NCBI
15	Wu XX, Kakehi Y, Jin XH, Inui M and Sugimoto M: Induction of apoptosis in human renal cell carcinoma cells by vitamin E succinate in caspase-independent manner. Urology. 73:193–199. 2009. View Article : Google Scholar : PubMed/NCBI
16	Clavien PA, Barkun J, de Oliveira ML, et al: The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg. 250:187–196. 2009.PubMed/NCBI
17	Liang P, Wang Y, Zhang D, Yu X, Gao Y and Ni X: Ultrasound guided percutaneous microwave ablation for small renal cancer: initial experience. J Urol. 180:844–848. 2008. View Article : Google Scholar : PubMed/NCBI
18	Castle SM, Salas N and Leveillee RJ: Initial experience using microwave ablation therapy for renal tumor treatment: 18-month follow-up. Urology. 77:792–797. 2011. View Article : Google Scholar : PubMed/NCBI
19	Carrafiello G, Laganà D, Ianniello A, et al: Percutaneous radiofrequency thermal ablation of renal cell carcinoma: is it possible a day-hospital treatment? Int J Surg. 6:31–35. 2008. View Article : Google Scholar : PubMed/NCBI
20	Carey RI and Leveillee RJ: First prize: direct real-time temperature monitoring for laparoscopic and CT-guided radiofrequency ablation of renal tumors between 3 and 5 cm. J Endourol. 21:807–813. 2007. View Article : Google Scholar : PubMed/NCBI
21	Shvarts O, Tsui KH, Smith RB, Kernion JB and Belldegrun A: Blood loss and the need for transfusion in patients who undergo partial or radical nephrectomy for renal cell carcinoma. J Urol. 164:1160–1163. 2000. View Article : Google Scholar : PubMed/NCBI
22	Muto G, Castelli E, Migliari R, D’Urso L, Coppola P and Collura D: Laparoscopic microwave ablation and enucleation of small renal masses: preliminary experience. Eur Urol. 60:173–176. 2011. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Microwave-induced thermoablation with Amica-probe is a safe and reproducible method to treat solid renal masses: Results from a phase I study

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Related Articles