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Article

Intensity-modulated stereotactic radiotherapy for the treatment of medically inoperable patients with NSCLC stage I

  • Authors:
    • Stephan Lächelt
    • Markus Alber
    • Matthias Söhn
    • Michael  Bamberg
    • Volker Steger
    • Martin Weinmann
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, University Hospital, D-72076 Tübingen, Germany, Section of Biomedical Physics, University Hospital of Radiation Oncology, D-72076 Tübingen, Germany, Section of Biomedical Physics, University Hospital of Radiation Oncology, D-81377 Munich, Germany, Department of Thoracic Surgery, University Hospital, D-72076 Tübingen, Germany
  • Pages: 1309-1314
    |
    Published online on: August 7, 2012
       https://doi.org/10.3892/or.2012.1953
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Abstract

The standard treatment for stage I non-small cell lung cancer (NSCLC) is lobectomy. However, a considerable number of patients are not eligible for standard lung surgery due to poor pulmonary function or comorbidities. We evaluated the efficacy and tolerability of intensity-modulated stereotactic radiotherapy (IMSRT) with moderate hypofractionation for these patients. Twelve patients were selected for IMSRT. 4D-CT planning was performed by gating CT-scanning positioning. The applied doses ranged between 10x4.5 Gy (80% ID) (N=1), 12x4.5 Gy (95% ID) (N=1) and 10x5.5 Gy (95% ID) (N=10). Long-term follow-up was performed including spirometry and CT for evaluation of local, locoregional and distant control. Even in patients with poor pulmonary function IMRST was safe and well tolerated. No severe acute adverse effects were observed. Estimated local control at 2 years was 90%. Moreover, IMSRT does not induce a significant deterioration of pulmonary function. IMRST is safe and feasible even for patients with very poor pulmonary function. The applied dose provides a high local control rate, although the biological equivalent dose (BED) is lower compared to the average of other SRT regimens. Therefore, IMRST may be an efficient alternative for all NSCLC stage I patients with contraindications to standard lobectomy especially in patients with small tumors in high-risk localisations.
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Copy and paste a formatted citation
Spandidos Publications style
Lächelt S, Alber M, Söhn M, Bamberg M, Steger V and Weinmann M: Intensity-modulated stereotactic radiotherapy for the treatment of medically inoperable patients with NSCLC stage I. Oncol Rep 28: 1309-1314, 2012.
APA
Lächelt, S., Alber, M., Söhn, M., Bamberg, M., Steger, V., & Weinmann, M. (2012). Intensity-modulated stereotactic radiotherapy for the treatment of medically inoperable patients with NSCLC stage I. Oncology Reports, 28, 1309-1314. https://doi.org/10.3892/or.2012.1953
MLA
Lächelt, S., Alber, M., Söhn, M., Bamberg, M., Steger, V., Weinmann, M."Intensity-modulated stereotactic radiotherapy for the treatment of medically inoperable patients with NSCLC stage I". Oncology Reports 28.4 (2012): 1309-1314.
Chicago
Lächelt, S., Alber, M., Söhn, M., Bamberg, M., Steger, V., Weinmann, M."Intensity-modulated stereotactic radiotherapy for the treatment of medically inoperable patients with NSCLC stage I". Oncology Reports 28, no. 4 (2012): 1309-1314. https://doi.org/10.3892/or.2012.1953
Copy and paste a formatted citation
x
Spandidos Publications style
Lächelt S, Alber M, Söhn M, Bamberg M, Steger V and Weinmann M: Intensity-modulated stereotactic radiotherapy for the treatment of medically inoperable patients with NSCLC stage I. Oncol Rep 28: 1309-1314, 2012.
APA
Lächelt, S., Alber, M., Söhn, M., Bamberg, M., Steger, V., & Weinmann, M. (2012). Intensity-modulated stereotactic radiotherapy for the treatment of medically inoperable patients with NSCLC stage I. Oncology Reports, 28, 1309-1314. https://doi.org/10.3892/or.2012.1953
MLA
Lächelt, S., Alber, M., Söhn, M., Bamberg, M., Steger, V., Weinmann, M."Intensity-modulated stereotactic radiotherapy for the treatment of medically inoperable patients with NSCLC stage I". Oncology Reports 28.4 (2012): 1309-1314.
Chicago
Lächelt, S., Alber, M., Söhn, M., Bamberg, M., Steger, V., Weinmann, M."Intensity-modulated stereotactic radiotherapy for the treatment of medically inoperable patients with NSCLC stage I". Oncology Reports 28, no. 4 (2012): 1309-1314. https://doi.org/10.3892/or.2012.1953
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